Yamixa Delgado^1,*, Caliani Gaytan¹, Naydi Perez², Eric Miranda³, Bryan Colón Morales¹, Mónica Santos¹

Congenital Heart Disease, Vol.19, No.1, pp. 19-31, 2024, DOI:10.32604/chd.2024.046339 - 20 March 2024

Abstract Background: Given the pervasive issues of obesity and diabetes both in Puerto Rico and the broader United States, there is a compelling need to investigate the intricate interplay among body mass index (BMI), pregestational, and gestational maternal diabetes, and their potential impact on the occurrence of congenital heart defects (CHD) during neonatal development. Methods: Using the comprehensive System of Vigilance and Surveillance of Congenital Defects in Puerto Rico, we conducted a focused analysis on neonates diagnosed with CHD between 2016 and 2020. Our assessment encompassed a range of variables, including maternal age, gestational age, BMI,… More >

Yanli Liu^1,2, Fengzhen Han², Jian Zhuang⁴, Yanqiu Ou⁴, Yanji Qu⁵, Yanyan Lin², Weina Zhang², Haiping Wang^3,*, Liping Huang^1,*

Congenital Heart Disease, Vol.18, No.5, pp. 561-570, 2023, DOI:10.32604/chd.2023.030511 - 10 November 2023

Abstract Background: Research on fetal congenital heart defect (CHD) mostly focuses on etiology and mechanisms. However, studies on maternal complications or pathophysiology are limited. Our objective was to determine whether vascular dysfunction exists in pregnant women carrying a fetus with congenital heart defects. Methods: We conducted a case-control study. 27 cases of pregnant women carrying a fetus with major CHD admitted to our hospital for delivery between April 2021 and August 2022 were selected. Every case was matched with about 2 pregnant complication-free controls without fetal abnormalities. The proangiogenic and anti-angiogenic factors and pregnancy outcomes were… More > Graphic Abstract

Daniel Sweeney¹, Scott Cohen^2,3, Salil Ginde^2,3, Jennifer Gerardin^2,3, Peter Bartz^2,3, Matthew Buelow^2,3,*

Congenital Heart Disease, Vol.18, No.3, pp. 315-323, 2023, DOI:10.32604/chd.2023.027349 - 09 June 2023

Abstract Background: Women with congenital heart disease (CHD) have increased risk for adverse events during pregnancy and delivery. Prior studies have assessed pregnancy and delivery outcomes at tertiary referral centers (TRC). The aim of our study was to assess pregnancy outcomes in women with CHD who deliver in a non-tertiary referral center (non-TRC). Methods: Clinical demographics were collected, including anatomic complexity, physiologic state and pre-pregnancy risk assessment. Patients were stratified by delivery location, either TRC or non-TRC. Maternal and neonatal complications of pregnancy were reported. Results: Women with CHD who delivered in a TRC had a higher… More > Graphic Abstract

C. Vairavel^1,*, N. S. Nithya²

Computer Systems Science and Engineering, Vol.46, No.2, pp. 2159-2175, 2023, DOI:10.32604/csse.2023.036598 - 09 February 2023

Abstract The immune system goes through a profound transformation during pregnancy, and certain unexpected maternal complications have been correlated to this transition. The ability to correctly examine, diagnoses, and predict pregnancy-hastened diseases via the available big data is a delicate problem since the range of information continuously increases and is scalable. Many approaches for disease diagnosis/classification have been established with the use of data mining concepts. However, such methods do not provide an appropriate classification/diagnosis model. Furthermore, single learning approaches are used to create the bulk of these systems. Classification issues may be made more accurate… More >

Sumayh S. Aljameel¹, Malak Aljabri^1,2, Nida Aslam¹, Dorieh M. Alomari^3,*, Arwa Alyahya¹, Shaykhah Alfaris¹, Maha Balharith¹, Hiessa Abahussain¹, Dana Boujlea¹, Eman S. Alsulmi⁴

CMC-Computers, Materials & Continua, Vol.75, No.1, pp. 1291-1304, 2023, DOI:10.32604/cmc.2023.035710 - 06 February 2023

Abstract Currently, the risk factors of pregnancy loss are increasing and are considered a major challenge because they vary between cases. The early prediction of miscarriage can help pregnant ladies to take the needed care and avoid any danger. Therefore, an intelligent automated solution must be developed to predict the risk factors for pregnancy loss at an early stage to assist with accurate and effective diagnosis. Machine learning (ML)-based decision support systems are increasingly used in the healthcare sector and have achieved notable performance and objectiveness in disease prediction and prognosis. Thus, we developed a model… More >

Ali Kheradmand¹, Sahar Ashrafzadeh², Farzane Rouzegari³, Samin Aliakbarian¹, Ali Naseh^4,*

International Journal of Mental Health Promotion, Vol.25, No.2, pp. 265-274, 2023, DOI:10.32604/ijmhp.2023.024773 - 02 February 2023

Abstract Drug abuse by pregnant women is one of the significant problems for mothers and their neonates. This study aimed to investigate the effects of maternal substance use disorder during pregnancy on neonatal developmental criteria. In a case-control study, clinical records of 90 neonates diagnosed with neonatal abstinence syndrome who were admitted to NICU in one of four hospitals affiliated with Shahid-Beheshti University of Medical Sciences in Tehran, Iran between 2017 and 2020 were compared to 90 neonates without neonatal abstinence syndrome (control group). Demographic information and data for neonatal developmental characteristics and complications were extracted… More >

LARISSA DANIELE BOBERMIN^1,*, LARA SCOPEL MEDEIROS², FERNANDA WEBER², GIANCARLO TOMAZZONI DE OLIVEIRA², LUCÉLIA SANTI^3,4,5, WALTER ORLANDO BEYS-DA-SILVA^3,4,5, CARLOS-ALBERTO GONÇALVES^1,2,6, ANDRÉ QUINCOZES-SANTOS^1,2,6

BIOCELL, Vol.46, No.12, pp. 2517-2523, 2022, DOI:10.32604/biocell.2022.021566 - 10 August 2022

Abstract Glial cells are crucial for maintaining central nervous system (CNS) homeostasis. They actively participate in immune responses, as well as form functional barriers, such as blood-brain barrier (BBB), which restrict the entry of pathogens and inflammatory mediators into the CNS. In general, viral infections during the gestational period can alter the embryonic and fetal environment, and the related inflammatory response may affect neurodevelopment and lead to behavioral dysfunction during later stage of life, as highlighted by our group for Zika virus infection. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) induces a cytokine storm and, during pregnancy,… More >

YANQIU LI^#,*, CHENJUN HAO^#, WEIYI CHEN, QINGJU MENG

BIOCELL, Vol.46, No.6, pp. 1565-1573, 2022, DOI:10.32604/biocell.2022.018347 - 07 February 2022

Abstract This work aimed to clarify the interaction between the fetus and pregnant patients with gestational diabetes mellitus (GDM), the lipid metabolomics analysis of the fetal umbilical cord blood of GDM patients and normal pregnant women were performed to screen out the specific lipid metabolites for pathogenesis of GDM. From 2019–2020, 21 patients with GDM and 22 normal pregnant women were enrolled in Hexian Memorial Hospital, Panyu District, Guangzhou. The general information such as weight, height, age, body mass index (BMI) before pregnancy were analyzed. Non-targeted metabonomic detection and analysis were performed in umbilical cord plasma… More >

Rachel Gardner¹, Emily Durbak¹, Rachael Baird², Katherine Singh², Jeff Chapa², David Majdalany^3,*

Congenital Heart Disease, Vol.17, No.2, pp. 147-160, 2022, DOI:10.32604/chd.2022.017366 - 26 January 2022

Abstract Background: There is limited literature written on the course and outcomes for pregnant mothers with Shone complex. Methods: We describe a case series of five pregnancies in four women with Shone complex within a multidisciplinary cardio-obstetrics clinic from 2016–2018. Results: Maternal age ranged from 21–39 years. Three patients had preserved left ventricular function while one had moderately decreased function. Gestational age at presentation ranged from 6–15 weeks. There were three successful pregnancies (mean gestational age = 37 weeks, range 35–39 weeks) with one patient accounting for two unsuccessful pregnancies. All infants were delivered via Cesarean section. One More >

JIABAO WU^1,2,#, XIAOHUA LIU^1,2,#, LU HAN^1,2, HUA NIE^1,2, YUAN TANG^1,2, YUNGE TANG^1,3, GE SONG^1,5, LIXIN ZHENG^1,4, WEIBING QIN^1,2,*

BIOCELL, Vol.46, No.4, pp. 1013-1023, 2022, DOI:10.32604/biocell.2022.016744 - 15 December 2021

Abstract Piwi-interacting RNAs (piRNAs) is a novel class of non-coding RNAs. However, changes in piRNA expression profiles in recurrent spontaneous abortion (RSA) have not yet been investigated. The aim of this study was to identify differentially expressed piRNAs in deciduas of RSA patients. Decidua tissues were collected by curettage from recruited RSA patients and normal early pregnant (NEP) women with their informed consent. Small RNA sequencing was used to evaluate the differences in piRNA expression profiles between RSA and NEP. The present results demonstrated that the counts of total piRNA reads in RSA samples were increased… More >