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  • Open Access

    REVIEW

    Revolutionizing stem cell research: unbiased insights through single-cell sequencing

    HAO WU#, NA HUO#, SITUO WANG, ZIWEI LIU, YI JIANG*, QUAN SHI*

    BIOCELL, Vol.48, No.11, pp. 1531-1542, 2024, DOI:10.32604/biocell.2024.054278 - 07 November 2024

    Abstract Stem cells have shown great application potential in wound repair, tissue regeneration, and disease treatment. Therefore, a full understanding of stem cells and their related regulatory mechanisms in disease treatment is conducive to improving the therapeutic effect of stem cells. However, thus far, there are still many unsolved mysteries in the field of stem cells due to technical limitations, which hinder the in-depth exploration of stem cells and their wide clinical application. Single-cell sequencing (SCS) has provided very powerful and unbiased insights into cell gene expression profiles at the single-cell level, bringing exciting results to More >

  • Open Access

    ARTICLE

    Improved Harris Hawks Algorithm and Its Application in Feature Selection

    Qianqian Zhang1, Yingmei Li1,*, Jianjun Zhan2,*, Shan Chen1

    CMC-Computers, Materials & Continua, Vol.81, No.1, pp. 1251-1273, 2024, DOI:10.32604/cmc.2024.053892 - 15 October 2024

    Abstract This research focuses on improving the Harris’ Hawks Optimization algorithm (HHO) by tackling several of its shortcomings, including insufficient population diversity, an imbalance in exploration vs. exploitation, and a lack of thorough exploitation depth. To tackle these shortcomings, it proposes enhancements from three distinct perspectives: an initialization technique for populations grounded in opposition-based learning, a strategy for updating escape energy factors to improve the equilibrium between exploitation and exploration, and a comprehensive exploitation approach that utilizes variable neighborhood search along with mutation operators. The effectiveness of the Improved Harris Hawks Optimization algorithm (IHHO) is assessed by… More >

  • Open Access

    ARTICLE

    Proposition de modélisation de la dynamique du système urbain : vitesse/densité/espace perçu Simulation de l’Ile de France

    Cyril Enault*

    Revue Internationale de Géomatique, Vol.33, pp. 273-293, 2024, DOI:10.32604/rig.2024.053490 - 26 August 2024

    Abstract La question environnementale est devenue un enjeu majeur de société dans les pays occidentaux et principalement en France. L’Ile de France est aujourd’hui au cœur de cette nouvelle politique de maitrise de l’expansion des agglomérations. Aussi l’étalement urbain et plus particulièrement sa mesure et son évaluation actuelle et future présente un véritable enjeu de société. L’exploration de l’étalement urbain est donc au cœur de la géographie et de l’Economie Géographique depuis le début des années 1980, période où s’amorcent les grands développements du périurbain. Fort de ces enjeux, cet article s’intéresse à la question de… More > Graphic Abstract

    Proposition de modélisation de la dynamique du système urbain : vitesse/densité/espace perçu Simulation de l’Ile de France

  • Open Access

    ARTICLE

    Belowground Bud Bank Is Insensitive to Short-Term Nutrient Addition in the Meadow Steppe of Inner Mongolia

    Jin Tao1, Jiatai Tian1, Dongmei Li1, Jinlei Zhu2, Qun Ma3, Zhiming Zhang1, Jungang Chen4, Yipeng Liu5, Jianqiang Qian1,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.6, pp. 1129-1141, 2024, DOI:10.32604/phyton.2024.051405 - 27 June 2024

    Abstract Human activities and industrialization have significantly increased soil nutrients, such as nitrogen (N) and phosphorus (P), profoundly impacting the composition and structure of plant community, as well as the ecosystem functions, especially in nutrient-limited ecosystems. However, as the key propagule pool of perennial grasslands, how belowground bud bank and its relationship with aboveground vegetation respond to short-term changes in soil nutrients was still unclear. In this study, we conducted a short-term (2021–2022) soil fertilization experiment with N addition (10 g N m yr) and P addition (5 g N m yr) in the meadow steppe… More >

  • Open Access

    ARTICLE

    Single-Nucleus RNA Sequencing Reveals Cardiac Macrophage Landscape in Hypoplastic Left Heart Syndrome

    Xiaozhuo Xu1,2, Yilin Huang1,2, Xu Han2,*

    Congenital Heart Disease, Vol.19, No.2, pp. 233-246, 2024, DOI:10.32604/chd.2024.050231 - 16 May 2024

    Abstract Background: Hypoplastic left heart syndrome (HLHS) is one of the most challenging congenital heart diseases in clinical treatment. In cardiac tissues, resident macrophages fulfill critical functions in maintaining a stable cardiac state and have strong regenerative capacity and organ specificity. However, the molecular mechanisms of macrophages in HLHS remained unclear. Methods: Single-nucleus RNA sequencing (snRNA-seq) data of HLHS and healthy control (donors) samples obtained from the Gene Expression Omnibus (GEO) database were normalized and clustered using the Seurat package. The “FindMarkers” function was used to screen differentially expressed genes (DEGs) between the HLHS and donor… More > Graphic Abstract

    Single-Nucleus RNA Sequencing Reveals Cardiac Macrophage Landscape in Hypoplastic Left Heart Syndrome

  • Open Access

    ARTICLE

    An Enhanced Multiview Transformer for Population Density Estimation Using Cellular Mobility Data in Smart City

    Yu Zhou1, Bosong Lin1, Siqi Hu2, Dandan Yu3,*

    CMC-Computers, Materials & Continua, Vol.79, No.1, pp. 161-182, 2024, DOI:10.32604/cmc.2024.047836 - 25 April 2024

    Abstract This paper addresses the problem of predicting population density leveraging cellular station data. As wireless communication devices are commonly used, cellular station data has become integral for estimating population figures and studying their movement, thereby implying significant contributions to urban planning. However, existing research grapples with issues pertinent to preprocessing base station data and the modeling of population prediction. To address this, we propose methodologies for preprocessing cellular station data to eliminate any irregular or redundant data. The preprocessing reveals a distinct cyclical characteristic and high-frequency variation in population shift. Further, we devise a multi-view More >

  • Open Access

    ARTICLE

    Comparison of QT Correction Methods in the Pediatric Population of a Community Hospital: A Retrospective Study

    Koren Hyogene Kwag1,*, Ibrahim Kak1, Ying Li2, Walid Khass1, Alec McKechnie1, Oksana Nulman1, Brande Brown1, Manoj Chhabra1

    Congenital Heart Disease, Vol.19, No.1, pp. 107-121, 2024, DOI:10.32604/chd.2024.045953 - 20 March 2024

    Abstract Objective: Accurate measurement of QT interval, the ventricular action potential from depolarization to repolarization, is important for the early detection of Long QT syndrome. The most effective QT correction (QTc) formula has yet to be determined in the pediatric population, although it has intrinsically greater extremes in heart rate (HR) and is more susceptible to errors in measurement. The authors of this study compare six different QTc methods (Bazett, Fridericia, Framingham, Hodges, Rautaharju, and a computer algorithm utilizing the Bazett formula) for consistency against variations in HR and RR interval. Methods: Descriptive Retrospective Study. We… More >

  • Open Access

    ARTICLE

    Study on Influencing Factors of Mental Health of Mobile Young White-Collar Workers in China

    Tao Liu1, Lin Liu1, Zeyu Chen1,*, Rong Fu2,*

    International Journal of Mental Health Promotion, Vol.26, No.2, pp. 127-138, 2024, DOI:10.32604/ijmhp.2023.045071 - 08 March 2024

    Abstract Mobile young white-collar workers not only have the characteristics of mobile young people, but also have the characteristics of general white-collar workers. Under the influence of both, their mental health may be suffering from “double disadvantage”. So, based on an ecological model of the stress process, this paper tries to use the data of the questionnaire on the mental health of mobile young white-collar workers in Zhejiang Province to explore the influence of some factors in the middle workplace and residence place on the mental health of micro individuals. The results show that: (1) The… More >

  • Open Access

    ARTICLE

    Comparative Study of Genetic Structure and Genetic Diversity between Wild and Cultivated Populations of Taxus cuspidata, Northeast China

    Dandan Wang, Xiaohong Li, Yanwen Zhang*

    Phyton-International Journal of Experimental Botany, Vol.93, No.2, pp. 355-369, 2024, DOI:10.32604/phyton.2024.047183 - 27 February 2024

    Abstract Taxus cuspidata is a rare plant with important medicinal and ornamental value. Aiming at the obvious differences between wild and cultivated populations of T. cuspidata from Northeast China, a total of 61 samples, that is, 33 wild yews and 28 cultivated yews were used to analyze the differences and correlations of the kinship, genetic diversity, and genetic structure between them by specific length amplified fragment sequencing (SLAF-seq). Finally, 470725 polymorphic SLAF tags and 58622 valid SNP markers were obtained. Phylogenetic analysis showed that 61 samples were classified into 2 clusters: wild populations and cultivated populations, and some… More >

  • Open Access

    ARTICLE

    Euler’s First-Order Explicit Method–Peridynamic Differential Operator for Solving Population Balance Equations of the Crystallization Process

    Chunlei Ruan1,2,*, Cengceng Dong1, Kunfeng Liang3, Zhijun Liu1, Xinru Bao1

    CMES-Computer Modeling in Engineering & Sciences, Vol.138, No.3, pp. 3033-3049, 2024, DOI:10.32604/cmes.2023.030607 - 15 December 2023

    Abstract Using Euler’s first-order explicit (EE) method and the peridynamic differential operator (PDDO) to discretize the time and internal crystal-size derivatives, respectively, the Euler’s first-order explicit method–peridynamic differential operator (EE–PDDO) was obtained for solving the one-dimensional population balance equation in crystallization. Four different conditions during crystallization were studied: size-independent growth, size-dependent growth in a batch process, nucleation and size-independent growth, and nucleation and size-dependent growth in a continuous process. The high accuracy of the EE–PDDO method was confirmed by comparing it with the numerical results obtained using the second-order upwind and HR-van methods. The method is More > Graphic Abstract

    Euler’s First-Order Explicit Method–Peridynamic Differential Operator for Solving Population Balance Equations of the Crystallization Process

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