YANG XU^1,#, HONGYUN LI^1,#, GE YOU^2,*

BIOCELL, Vol.48, No.2, pp. 229-237, 2024, DOI:10.32604/biocell.2023.045030 - 23 February 2024

Abstract Background: Colorectal cancer (CRC) constitutes the leading cause of death worldwide. Chemoresistance and tumor immune evasion are critical contributors to therapeutic failure in cancer patients. CKLF-like MARVEL transmembrane domain-containing 6 (CMTM6) is aberrantly expressed in various cancers and can regulate tumor immunity. However, its role in chemoresistance and tumor immunity of CRC is not well understood. Methods: Online bioinformatics tools were used to analyze expression and prognosis of CMTM6 in CRC patients. CRC cells were transfected with si-CMTM6. Subsequently, the effects on CRC cell viability and chemoresistance were investigated by CCK-8 assay and flow cytometer.… More > Graphic Abstract

YUN ZHANG^1,2,#, SHALING TANG^1,2,#, YUBO GAO^1,2, ZHONGTING LU^1,2, YUAN YANG^1,2, JING CHEN³, TAO LI^4,*

Oncology Research, Vol.32, No.1, pp. 61-71, 2024, DOI:10.32604/or.2023.043481 - 15 November 2023

Abstract Colorectal cancer (CRC) is a major global health problem with high morbidity and mortality rates. Surgical resection is the main treatment for early-stage CRC, but detecting it early is challenging. Therefore, effective therapeutic targets for advanced patients are still lacking. Exosomes, tiny vesicles in body fluids, play a crucial role in tumor metastasis, immune regulation, and drug resistance. Interestingly, they can even serve as a biomarker for cancer diagnosis and prognosis. Studies have shown that exosomes can carry miRNA, mediate the polarization of M1/M2 macrophages, promote the proliferation and metastasis of cancer cells, and affect More > Graphic Abstract

RABIRANJAN MURMU^a,b, DEBASHIS ROY^a, HAREKRUSHNA SUTAR^b

Journal of Polymer Materials, Vol.40, No.3-4, pp. 125-139, 2023, DOI:10.32381/JPM.2023.40.3-4.1

Abstract A one dimensional isothermal model is proposed by modelling the kinetics of methanol transport at anode flow channel (AFC), membrane and cathode catalyst layer of direct methanol fuel cell (DMFC). Analytical model is proposed to predict methanol cross-over rate through the electrolyte membrane and cell performance. The model presented in this paper considered methanol diffusion and electrochemical oxidation at the anode and cathode channels. The analytical solution of the proposed model was simulated in a MATLAB environment to obtain the polarization curve and leakage current. The effect of methanol concentration on cell voltage and leakage More >

Yong Zhang^1,*, Jie Wang^2,3

The International Conference on Computational & Experimental Engineering and Sciences, Vol.27, No.1, pp. 1-1, 2023, DOI:10.32604/icces.2023.09368

Abstract Ferroelectric materials have been widely used in various electromechanical devices such as sensors, actuators, transducers and energy storage devices due to their distinguished electromechanical coupling properties. Ferroelectric materials usually bear large mechanical loads and high electric fields in order to give full play to their potential. The interaction between fracture and dielectric breakdown is able to occur since the filler inside a crack will change the dielectric behaviors around it and dielectric breakdown can change the local mechanical properties of dielectric materials because of its weakening of chemical bonds. Therefore, a comprehensive and in-depth understanding… More >

Md. Salah Uddin Afsar¹, Mohammad Rashed Iqbal Faruque^1,*, Sabirin Abdullah¹, Mohammad Tariqul Islam²

CMC-Computers, Materials & Continua, Vol.76, No.1, pp. 455-469, 2023, DOI:10.32604/cmc.2023.036655 - 08 June 2023

Abstract This study proposed a new royal crown-shaped polarisation insensitive double negative triple band microwave range electromagnetic metamaterial absorber (MA). The primary purpose of this study is to utilise the exotic characteristics of this perfect metamaterial absorber (PMA) for microwave wireless communications. The fundamental unit cell of the proposed MA consists of two pentagonal-shaped resonators and two inverse C-shaped metallic components surrounded by a split ring resonator (SRR). The bottom thin copper deposit and upper metallic resonator surface are disjoined by an FR-4 dielectric substrate with 1.6 mm thickness. The CST MW studio, a high-frequency electromagnetic… More >

GUSTAVO MARTÍN VILLOLDO¹, MARÍA TERESA POMBO², MARIANA ARIS³, JOAQUÍN CHEMI¹, PABLO MANDÓ³, SUPRIYA NAGARAJU⁴, JUAN CAMEAN¹, ADRIÁN BURIONI¹, DEBORAH EGEA¹, MORA AMAT⁵, JOSÉ LEÓN MELLADO³, JOSÉ MORDOH³, ALBERTO VILLARONGA¹, MARÍA MARCELA BARRIO^3,*

Oncology Research, Vol.31, No.2, pp. 207-220, 2023, DOI:10.32604/or.2023.028163 - 10 April 2023

Abstract Intravesical Bacillus Calmette Guerin (BCG) is the gold standard therapy for intermediate/high-risk nonmuscle invasive bladder cancer (NMIBC). However, the response rate is ~60%, and 50% of non-responders will progress to muscle-invasive disease. BCG induces massive local infiltration of inflammatory cells (Th1) and ultimately cytotoxic tumor elimination. We searched for predictive biomarker of BCG response by analyzing tumor-infiltrating lymphocyte (TIL) polarization in the tumor microenvironment (TME) in pre-treatment biopsies. Pre-treatment biopsies from patients with NMIBC who received adequate intravesical instillation of BCG (n = 32) were evaluated retrospectively by immunohistochemistry. TME polarization was assessed by quantifying… More > Graphic Abstract

Haoran Wei, Tian Ji, Jianqing Huang^*

Journal of Renewable Materials, Vol.11, No.2, pp. 731-743, 2023, DOI:10.32604/jrm.2022.022283 - 22 September 2022

Abstract Simultaneous broadband absorption and polarization conversion are crucial in many practical applications, especially in terahertz communications. Thus, actively tunable metamaterial systems can exploit the graphene-based nanomaterials derived from renewable resources because of the flexible surface conductivity and selective permeability of the nanomaterials at terahertz frequencies. In this paper, we propose a graphene-based active tunable bifunctional metasurface for dynamic terahertz absorption and polarization conversion. The graphene ring presents a certain opening angle (A) along the diagonal of the xoy plane. When A = 0°, the proposed metasurface behaves as a broadband absorber. Numerical results show the feasibility… More >

Ankush Kapoor¹, Pradeep Kumar^2,*, Ranjan Mishra³

CMC-Computers, Materials & Continua, Vol.74, No.1, pp. 341-361, 2023, DOI:10.32604/cmc.2023.028874 - 22 September 2022

Abstract Frequency selective surfaces (FSSs) play an important role in wireless systems as these can be used as filters, in isolating the unwanted radiation, in microstrip patch antennas for improving the performance of these antennas and in other 5G applications. The analysis and design of the double concentric ring frequency selective surface (DCRFSS) is presented in this research. In the sub-6 GHz 5G FR1 spectrum, a computational synthesis technique for creating DCRFSS based spatial filters is proposed. The analytical tools presented in this study can be used to gain a better understanding of filtering processes and… More >

Jae Hee Seol^1,4,#, Se Yong Jung^1,#, Jae Young Choi¹, Han Ki Park², Young Hwan Park², Nam Kyun Kim^1,3,*

Congenital Heart Disease, Vol.17, No.5, pp. 569-578, 2022, DOI:10.32604/chd.2022.018436 - 06 September 2022

Abstract Objective: Junctional ectopic tachycardia is common after cardiac surgery for congenital heart disease. However, its incidence and related risk factors in infants after cardiac surgery are not well known. The objective of this study was to determine the overall incidence and related risk factors for junctional ectopic tachycardia in neonates and infants. Methods: We enrolled a total of 271 patients aged <1 year who underwent open cardiac surgery at Severance Cardiovascular Hospital from January 2018 to December 2020. Exclusion criteria were immediate postoperative mortality, other arrhythmias detected in the perioperative period, and prematurity. Result: The overall incidence of… More >

M. Hashim Dahri¹, M. H. Jamaluddin², M. Inam³, M. R. Kamarudin⁴, F. C. Seman⁴, A. Y. I. Ashyap⁴, Z. A. Shamsan^5,*, K. Almuhanna⁵, F. Alorifi⁵

CMC-Computers, Materials & Continua, Vol.73, No.3, pp. 6085-6101, 2022, DOI:10.32604/cmc.2022.031532 - 28 July 2022

Abstract A reflectarray antenna consisting of asymmetrical patch elements is proposed, which is capable of producing dual linear and dual circular polarized operation at 26 GHz frequency. The main purpose of this design is to support four different polarizations using the same patch element. The proposed reflectarray has a single layer configuration with a linearly polarized feed and circular ring slots in the ground plane. Asymmetric patch element is designed from a square patch element by tilting its one vertical side to some optimized inclination. A wide reflection phase range of 600° is obtained with the asymmetric… More >