Keyuan Chen¹, Xingkao Zhang¹, Li Ma¹, Jueyi Ye¹, Qi Qiu¹, Haoxiang Zhang¹, Ju Rong^1,*, Yudong Sui^1,*, Xiaohua Yu^1,2, Jing Feng¹

CMC-Computers, Materials & Continua, Vol.83, No.1, pp. 685-700, 2025, DOI:10.32604/cmc.2025.060713 - 26 March 2025

Abstract The deep potential (DP) is an innovative approach based on deep learning that uses ab initio calculation data derived from density functional theory (DFT), to create high-accuracy potential functions for various materials. Platinum (Pt) is a rare metal with significant potential in energy and catalytic applications, However, there are challenges in accurately capturing its physical properties due to high experimental costs and the limitations of traditional empirical methods. This study employs deep learning methods to construct high-precision potential models for single-element systems of Pt and validates their predictive performance in complex environments. The newly developed DP… More >

ENRICO CALIMAN^1,2, SARA FANCELLI^1,2, FEDERICO SCOLARI³, ADRIANO PASQUI⁴, CLARA MANNESCHI⁴, DANIELE LAVACCHI¹, FRANCESCA MAZZONI⁴, FRANCESCA GENSINI⁵, VALERIA PASINI⁶, CAMILLA EVA COMIN^2,7, LUCA VOLTOLINI^2,8, SERENA PILLOZZI^1,2,*, LORENZO ANTONUZZO^1,2,4

Oncology Research, Vol.33, No.1, pp. 45-55, 2025, DOI:10.32604/or.2024.050161 - 20 December 2024

Abstract Background: Platinum chemotherapy (CT) remains the backbone of systemic therapy for patients with small-cell lung cancer (SCLC). The nucleotide excision repair (NER) pathway plays a central role in the repair of the DNA damage exerted by platinum agents. Alteration in this repair mechanism may affect patients’ survival. Materials and Methods: We conducted a retrospective analysis of data from 38 patients with extensive disease (ED)-SCLC who underwent platinum-CT at the Clinical Oncology Unit, Careggi University Hospital, Florence (Italy), from 2015 to 2020. mRNA expression analysis and single nucleotide polymorphism (SNP) characterization of three NER pathway genes—namely ERCC1, ERCC2,… More >

Stefanos Tzelepis^*, Kosmas A. Kavadias

Energy Engineering, Vol.119, No.5, pp. 1745-1769, 2022, DOI:10.32604/ee.2022.020984 - 21 July 2022

Abstract

The constant increase in energy demand and related environmental issues have made fuel cells an attractive technology as an alternative to conventional energy technologies. Like any technology, fuel cells face drawbacks that scientific society has been focused on to improve and optimize the overall technology. Thus, the cost is the main inhibitor for this technology due to the significantly high cost of the materials used in catalyst layers. The current discussion mainly focuses on the fundamental electrochemical half-cell reaction of hydrogen oxidation reaction (HOR) and oxygen reduction reaction (ORR) that are taking place in the

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Yue-shen Wang^*1, Jing Tian^†1, Yong Han^†, Shu-mei Han^†, Sheng-bin Shi^†

Oncology Research, Vol.24, No.2, pp. 129-135, 2016, DOI:10.3727/096504016X14618564639213

Abstract We evaluated the efficacy and feasibility of the combination of gemcitabine plus vinorelbine in patients with platinum-based chemotherapy-refractory esophageal cancer. We enrolled 35 patients who received gemcitabine plus vinorelbine as second-line treatment after platinum-based chemotherapy failure between May 2009 and April 2012. Dosage: gemcitabine 1,000 mg/m² plus vinorelbine 25 mg/m² ; all drugs were administered on days 1 and 8 of a 21-day cycle, and this was continued until failure or unacceptable toxicity. A total of 125 cycles of treatment were administered, and all patients received at least two cycles of treatment (two to five cycles;… More >