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  • Open Access

    REVIEW

    Monocyte Phenotypic Plasticity in Peripheral Artery Disease: From Pathophysiology to Therapeutic Targets

    Gizem Kaynar Beyaz1,*, Ahmet Kirbas2, Sevgi Kalkanli Tas1

    BIOCELL, Vol.50, No.1, 2026, DOI:10.32604/biocell.2025.072368 - 23 January 2026

    Abstract Peripheral artery disease (PAD) remains a significant global health issue, with current treatments primarily focused on relieving symptoms and addressing macrovascular issues. However, critical immunoinflammatory mechanisms are often overlooked. Recent evidence suggests that monocyte phenotypic plasticity plays a central role in PAD development, affecting atherogenesis, plaque progression, ischemia-reperfusion injury, and chronic ischemic remodeling. This narrative review aims to summarize the latest advances (2023–2025) in understanding monocyte diversity, functional states, and their changes throughout different stages of PAD. We discuss both established and emerging biomarkers, such as circulating monocyte subset proportions, functional assays, immune checkpoint expression, More >

  • Open Access

    ARTICLE

    A Temperature-Indexed Concrete Damage Plasticity Model Incorporating Bond-Slip Mechanism for Thermo-Mechanical Analysis of Reinforced Concrete Structures

    Wu Feng1,2,*, Tengku Anita Raja Hussin1, Xu Yang3

    Structural Durability & Health Monitoring, Vol.20, No.1, 2026, DOI:10.32604/sdhm.2025.071664 - 08 January 2026

    Abstract This study investigates the thermo–mechanical behavior of C40 concrete and reinforced concrete subjected to elevated temperatures up to 700°C by integrating experimental testing and advanced numerical modeling. A temperature-indexed Concrete Damage Plasticity (CDP) framework incorporating bond–slip effects was developed in Abaqus to capture both global stress–strain responses and localized damage evolution. Uniaxial compression tests on thermally exposed cylinders provided residual strength data and failure observations for model calibration and validation. Results demonstrated a distinct two-stage degradation regime: moderate stiffness and strength reduction up to ~400°C, followed by sharp deterioration beyond 500°C–600°C, with residual capacity at… More >

  • Open Access

    ARTICLE

    Revisiting Nonlinear Modelling Approaches for Existing RC Structures: Lumped vs. Distributed Plasticity

    Hüseyin Bilgin*, Bredli Plaku

    Structural Durability & Health Monitoring, Vol.20, No.1, 2026, DOI:10.32604/sdhm.2025.071007 - 08 January 2026

    Abstract Nonlinear static procedures are widely adopted in structural engineering practice for seismic performance assessment due to their simplicity and computational efficiency. However, their reliability depends heavily on how the nonlinear behaviour of structural components is represented. The recent earthquakes in Albania (2019) and Türkiye (2023) have underscored the need for accurate assessment techniques, particularly for older reinforced concrete buildings with poor detailing. This study quantifies the discrepancies between default and user-defined component modelling in pushover analysis of pre-modern reinforced concrete structures, analysing two representative low- and mid-rise reinforced concrete frame buildings. The lumped plasticity approach… More > Graphic Abstract

    Revisiting Nonlinear Modelling Approaches for Existing RC Structures: Lumped vs. Distributed Plasticity

  • Open Access

    PROCEEDINGS

    Resolving Self-Stress Artifacts in Twin Boundary Migration: A Stress Correction Scheme for the CPFE-PF Model of HCP Alloys

    Linfeng Jiang1,*, Guisen Liu1, Yao Shen1, Jian Wang2

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.33, No.3, pp. 1-1, 2025, DOI:10.32604/icces.2025.011397

    Abstract The plastic deformation of Mg/Ti alloys arises from the synergistic interplay of dislocation slip and deformation twinning. To model these mechanisms, we previously developed a mesoscale CPFE-PF framework that couples crystal plasticity finite element (CPFE) and phase field (PF) methods, enabling predictions of microstructure evolution and mechanical behavior under complex loading. A central challenge, however, lies in accurately capturing deformation twinning—a process critical for accommodating shear and reorienting crystal domains in low-symmetry metals. Twin propagation and thickening occur via twinning dislocations/disconnections at the atomic scale, while at larger scales they are governed by the migration… More >

  • Open Access

    PROCEEDINGS

    Internal Connection Between the Microstructures and the Mechanical Properties in Additive Manufacturing

    Yifei Wang, Zhao Zhang*

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.33, No.3, pp. 1-1, 2025, DOI:10.32604/icces.2025.011121

    Abstract Additive manufacturing (AM) reveals high anisotropy in mechanical properties due to the thermal accumulation induced microstructures. How to reveal the internal connection between the microstructures and the mechanical properties in additive manufacturing is a challenge. There are many methods to predict the mechanical properties based on the microstructural evolutions in additive manufacturing [1–3]. Here we summarized the main methods for the prediction of the mechanical properties in additive manufacturing, including crystal plasticity finite element method (CPFEM), dislocation dynamics (DD), and molecular dynamics (MD). We systematically examine these primary approaches for mechanical property predictions in AM,… More >

  • Open Access

    PROCEEDINGS

    Morphing of Inorganic Perovskite Semiconductors Without Compromising Their Functional Properties

    Xiaocui Li1, Fu-Rong Chen1,*, Yang Lu2,*

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.33, No.1, pp. 1-1, 2025, DOI:10.32604/icces.2025.010503

    Abstract Traditionally, it is relatively easy to process metal materials and polymers (plastics), while ceramic and inorganic semiconductor materials are hard to process, due to their intrinsic brittleness caused by directional covalent bonds or strong electrostatic interactions among ionic species. This brittleness can degrade semiconductor performance and lead to catastrophic failures, thereby limiting their application scenarios and service lifetime. Achieving room-temperature deformability in semiconductor materials without compromising their functionality has been a long-standing goal in materials science. Recently, room-temperature ductile semiconductors have emerged, with their deformability enhanced by factors such as size effects, fewer pre-existing micro-cracks,… More >

  • Open Access

    ARTICLE

    Investigating Drought Resilience in Fig Cultivars: A Comprehensive Study of Leaf Structural and Functional Characteristics

    Nouha Haoudi1,2, Lahcen Hssaini1, Jamila Bahhou2, Abderrahim Bentaibi1, Hicham Aboumadane1,2, Rachid Razouk1,*

    Phyton-International Journal of Experimental Botany, Vol.94, No.6, pp. 1857-1877, 2025, DOI:10.32604/phyton.2025.065116 - 27 June 2025

    Abstract This study was carried out to assess plasticity to drought of 30 adult fig cultivars, based on a screening of leaf structural and functional traits under sustained deficit irrigation, corresponding to 60% of crop evapotranspiration. All trees, three per cultivar, are planted in an ex-situ collection in Sais plain, northern Morocco. The measurements concerned leaf area, blade thickness, trichomes density, trichome hair length, stomatal density, stomatal dimensions, stomatal area index, chlorophyll concentration index, relative water content, stomatal conductance, leaf temperature, water loss in detached leaves, cuticular wax content, proline content, total phenolic compounds, and total soluble… More >

  • Open Access

    REVIEW

    Plasticity of myeloid-derived suppressor cells in cancer and cancer therapy

    JIAJIA LV, XIAOYOU ZHONG, LIN WANG, WEIFEI FAN*

    Oncology Research, Vol.33, No.7, pp. 1581-1592, 2025, DOI:10.32604/or.2025.060063 - 26 June 2025

    Abstract The tumor microenvironment (TME) is a complex and dynamic network comprised of tumor cells, surrounding cellular components, various signaling molecules, and the stroma. Myeloid-derived suppressor cells (MDSCs) are pivotal players in the immunosuppressive landscape of the TME, effectively hindering antitumor immune responses and facilitating tumor progression. Originating from pathologically activated myeloid precursors and relatively immature myeloid cells, MDSCs retain plasticity to further differentiate into other myeloid cells, such as macrophages or dendritic cells, which underpins their heterogeneity and adaptability in response to the TME. In this review, we delve into the plasticity of MDSCs in More >

  • Open Access

    ARTICLE

    An Improved Local RBF Collocation Method for 3D Excavation Deformation Based on Direct Method and Mapping Technique

    Cheng Deng1,2, Hui Zheng2,*, Liangyong Gong1, Rongping Zhang1, Mengqi Wang3

    CMES-Computer Modeling in Engineering & Sciences, Vol.142, No.2, pp. 2147-2172, 2025, DOI:10.32604/cmes.2025.059750 - 27 January 2025

    Abstract Since the plasticity of soil and the irregular shape of the excavation, the efficiency and stability of the traditional local radial basis function (RBF) collocation method (LRBFCM) are inadequate for analyzing three-dimensional (3D) deformation of deep excavation. In this work, the technique known as the direct method, where the local influence nodes are collocated on a straight line, is introduced to optimize the LRBFCM. The direct method can improve the accuracy of the partial derivative, reduce the size effect caused by the large length-width ratio, and weaken the influence of the shape parameters on the More >

  • Open Access

    PROCEEDINGS

    Nonlocal Crystal Plasticity Modeling of Heterostructured Materials

    Jianfeng Zhao1,*, Xu Zhang2, Guozheng Kang2, Michael Ziaser3

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.31, No.4, pp. 1-1, 2024, DOI:10.32604/icces.2024.012582

    Abstract A continuum model of dislocation transport incorporating grain boundary transmission was developed within a dislocation-based crystal plasticity framework, which was then adopted to study the deformation mechanisms of gradient-structured material and bimodal-grained material. The nonlocal nature of the model on the slip system level enables the direct investigation of strain gradient effects caused by internal deformation heterogeneities. Furthermore, the interaction between dislocations and grain boundaries leads to the formation of pileups near grain boundaries, which is key to studying the grain size effects in polycrystals. Finite element implementation of the model for polycrystals with different… More >

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