Yanli Liu1,2, Fengzhen Han2, Jian Zhuang4, Yanqiu Ou4, Yanji Qu5, Yanyan Lin2, Weina Zhang2, Haiping Wang3,*, Liping Huang1,*
Congenital Heart Disease, Vol.18, No.5, pp. 561-570, 2023, DOI:10.32604/chd.2023.030511
- 10 November 2023
Abstract Background: Research on fetal congenital heart defect (CHD) mostly focuses on etiology and mechanisms. However, studies on maternal complications or pathophysiology are limited. Our objective was to determine whether vascular dysfunction exists in pregnant women carrying a fetus with congenital heart defects. Methods: We conducted a case-control study. 27 cases of pregnant women carrying a fetus with major CHD admitted to our hospital for delivery between April 2021 and August 2022 were selected. Every case was matched with about 2 pregnant complication-free controls without fetal abnormalities. The proangiogenic and anti-angiogenic factors and pregnancy outcomes were… More >
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