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  • Open Access

    ARTICLE

    Structural Characterization of Chloroplast Genome in Alpinia japonica (Thunb.) Miq., a Medicinal Plant of the Genus Alpinia

    Wentao Sheng, Xi Lei, Xinjie Chen, Quan Kuang*

    Phyton-International Journal of Experimental Botany, Vol.93, No.8, pp. 1897-1911, 2024, DOI:10.32604/phyton.2024.052395

    Abstract The analysis of chloroplast gene characteristics in Alpinia japonica (Thunb.) Miq. is of great significance for developing relevant genetic resources. The high-throughput sequencing and bioinformatic research were performed to analyze the chloroplast genome characteristics of A. japonica. The total chloroplast genome length of A. japonica was 161,906 bp, with a typical circular tetrameric structure. And 133 genes were annotated, comprising 87 protein-coding, 38 tRNA, and 8 rRNA genes. Furthermore, 22 genes contained two copies, and 18 genes owned introns. Repeat sequence analysis showed that it contains 321 simple sequence repeats (SSRs) and 37 long segment repeats. Compared with… More >

  • Open Access

    ARTICLE

    Phylogenetic analysis of microRNA biomarkers for amyotrophic lateral sclerosis

    HSIUYING WANG1,2,*

    BIOCELL, Vol.45, No.3, pp. 547-561, 2021, DOI:10.32604/biocell.2021.014343

    Abstract Amyotrophic lateral sclerosis (ALS), also called Lou Gehrig’s disease, is an irreversible disease that is caused by the degeneration and death of motor neurons. Approximately 5–10% of cases are familial ALS (fALS), and the other cases are sporadic ALS (sALS). Gene mutations have been identified both in fALS and sALS patients. In this study, we discuss the four ALS-related genes, C9orf72, SOD1, FUS, and TARDBP, and review the microRNAs (miRNAs) that are associated with ALS and other neurological disorders from the literature. A phylogenetic analysis is used to explore potential miRNAs that can be taken More >

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