Cheng-Jen Ma^*†‡, Ching-Wen Huang^*‡§, Yung-Sung Yeh^*†¶, Hsiang-Lin Tsai^*§#**, Huang-Ming Hu^††‡‡, I-Chen Wu^††‡‡, Tian-Lu Cheng^§§¶¶, Jaw-Yuan Wang^{*†‡§**¶¶}

Oncology Research, Vol.25, No.5, pp. 673-679, 2017, DOI:10.3727/97818823455816X14786040691928

Abstract We analyzed the results of previously treated patients with metastatic colorectal cancer (mCRC) who received regorafenib plus FOLFIRI with the irinotecan dose escalation on the basis of uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) genotyping. Thirteen patients with previously treated mCRC were subjected to UGT1A1 genotyping between October 2013 and June 2015 and were administered regorafenib plus FOLFIRI with irinotecan dose escalation. Patients with UGT1A1*1/*1 and *1/*28 genotypes were administered 180 mg/m² of irinotecan, whereas those with the UGT1A1*28/*28 genotype were administered 120 mg/m2 of irinotecan. For all patients, the irinotecan dose was increased by 30 mg/m2 every… More >

Wang Cuiyue¹, Feng Zhen², Jiang Kaitong³, Zuo Xiuli¹

Oncology Research, Vol.25, No.4, pp. 559-569, 2017, DOI:10.3727/096504016X14759554689565

Abstract THIS ARTICLE WAS WITHDRAWN BY THE PUBLISHER IN NOVEMBER 2020 More >

Meng Yang^*, Xu Zhai^†, Tingting Ge^*, Chang Yang^*, Ge Lou^*

Oncology Research, Vol.26, No.5, pp. 703-712, 2018, DOI:10.3727/096504017X14982569377511

Abstract Expression of miR-181a-5p associates with the proliferation and progression of cancer cells via its targets. This study was designed to investigate the effect of miR-181a-5p and its target inositol polyphosphate-5- phosphatase A (INPP5A) on the progression of cervical cancers. Upregulation of miR-181a-5p was revealed in the cervical cancer cell lines HeLa and SiHa in comparison with a normal cervical epithelium cell line End1/ E6E7 (p<0.001). The inhibition and upregulation of miR-181a-5p in cervical cancer cell lines significantly reduced or increased cell proliferation and invasion capacity, accompanied with enhanced or reduced apoptosis (p<0.05). Moreover, INPP5A overexpression significantly More >

Zhongping Liu¹, Enhui Sun^2,*, Jiahao Shi², Lei Zhang², Qi Wang¹, Jiali Dong¹

Energy Engineering, Vol.121, No.4, pp. 913-932, 2024, DOI:10.32604/ee.2023.043973

Abstract There is a growing need to explore the potential of coal-fired power plants (CFPPs) to enhance the utilization rate of wind power (wind) and photovoltaic power (PV) in the green energy field. This study developed a load regulation model for a multi-power generation system comprising wind, PV, and coal energy storage using real-world data. The power supply process was divided into eight fundamental load regulation scenarios, elucidating the influence of each scenario on load regulation. Within the framework of the multi-power generation system with the wind (50 MW) and PV (50 MW) alongside a CFPP… More > Graphic Abstract

Zhifen Shi^1,3, Fumei Pan^1,3, Xiaotian Kong², Jiaqi Lang³, Mingyan Ye³, Qian Wu⁴, Guangzhi Wang^1,*, Liang Han^5,*, Nong Zhou^3,*

Phyton-International Journal of Experimental Botany, Vol.93, No.2, pp. 247-260, 2024, DOI:10.32604/phyton.2024.046452

Abstract Fritillaria taipaiensis P. Y. Li is a widely used medicinal herb in treating pulmonary diseases. In recent years, its wild resources have become scarce, and the demand for efficient artificial cultivation has significantly increased. This article is the first to apply phosphate solubilizing bacteria isolated from the rhizosphere soil of F. taipaiensis P. Y. Li to the cultivation process of F. taipaiensis P. Y. Li. The aim is to identify suitable reference strains for the artificial cultivation and industrial development of F. taipaiensis P. Y. Li by examining the effects of various phosphate solubilizing bacteria and their combinations on… More >

Ying Ji^*, Xi Liu^*

Journal of Renewable Materials, Vol.11, No.11, pp. 3977-3989, 2023, DOI:10.32604/jrm.2023.028439

Abstract The problem of low disposal and utilization rate of bulk industrial solid waste needs to be solved. In this paper, a high-activity admixture composed of steel slag-phosphate slag-limestone powder was proposed for most of the solid waste with low activity and a negative impact on concrete workability, combining the characteristics of each solid waste. The paper demonstrates the feasibility and explains the principle of the composite system in terms of water requirement of standard consistency, setting time, workability, and mechanical properties, combined with the composition of the phases, hydration temperature, and microscopic morphology. The results… More > Graphic Abstract

Tianshu Wang¹, Guoqing Sun¹, Shaojun Zhang¹, Mingyu Wang¹, Jixin Wang², Yunwu Han^3,*

FDMP-Fluid Dynamics & Materials Processing, Vol.19, No.11, pp. 2923-2932, 2023, DOI:10.32604/fdmp.2023.028740

Abstract In typical metal foundry applications, sand casting is still the most used technology. The related binder plays a very important role as its performances can directly influence the quality of castings. Among many binders, glues of animal origin have attracted much attention in recent years due to their reduced environmental impact. However, they display some drawbacks such as the tendency to coagulate easily at room temperature and a relatively low strength. In this study, a novel gas-hardening casting binder was prepared using an animal glue and anhydrous potassium carbonate as a hydrolyzing agent to avoid… More >

Zhijian Zhou¹, Jie Yan^1,*, Xinxiang Du¹, Qiulin Xu¹, Zijun Wu², Jinlan Yang³, Xitong Fang¹, Qiuling Zhong², Qiaoguang Li^1,*

Journal of Renewable Materials, Vol.11, No.9, pp. 3501-3515, 2023, DOI:10.32604/jrm.2023.027852

Abstract Iron-pillared bentonite (FB) was prepared by Fe(III) modified bentonite, and then the composites (FB-OS) were prepared by iron-pillared bentonite and oyster shell powder. The composites were characterized by FTIR, SEM, TGA, and EDS, and the phosphorus removal test was carried out. The results showed that FB-OS contained a large amount of CaO. Its structure was compact, but there were gaps in it. The maximum bending stress and compressive strength were 43.7 N and 0.927 MPa, respectively. The phosphorus removal test showed that the phosphorus removal rate of FB-OS was more than 90%, and measured the More > Graphic Abstract

Yangyang Du¹, Yuanyuan Bao², Lu Zheng¹, Qinglong Tian¹, Xinyong Zhang^1,*

Phyton-International Journal of Experimental Botany, Vol.92, No.8, pp. 2325-2348, 2023, DOI:10.32604/phyton.2023.027642

Abstract Inorganic phosphate (Pi) is one of the main nutrients necessary for plant growth. Phosphate transporters mediate the acquisition, transport and recycling of phosphate, which is essential for plant growth and development. Although PHT1 has been reported in many plants at home and abroad, it is rarely studied in potato. Therefore, it is of great significance to study the PHT1 family members in order to understand the molecular response mechanism of potato in low phosphate state. In this study, a total of 6 potato PHT1 genes were identified and isolated. It was found that after the expression of… More >

Enhui Sun^1,2, Jiahao Shi^1,2, Lei Zhang^1,2,*, Hongfu Ji^1,2, Qian Zhang^1,2, Yongyi Li^1,2

Energy Engineering, Vol.120, No.7, pp. 1583-1602, 2023, DOI:10.32604/ee.2023.027790

Abstract This paper studies the feasibility of a supply-side wind-coal integrated energy system. Based on grid-side data, the load regulation model of coal-fired power and the wind-coal integrated energy system model are established. According to the simulation results, the reasons why the wind-coal combined power supply is difficult to meet the grid-side demand are revealed through scenario analysis. Based on the wind-coal combined operation, a wind-coal-storage integrated energy system was proposed by adding lithium-iron phosphate battery energy storage system (LIPBESS) to adjust the load of the system. According to the four load adjustment scenarios of grid-side… More >