Ivan Karpunin^*

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.6, pp. 1219-1232, 2024, DOI:10.32604/fdmp.2024.051062

Abstract The dynamics of a solid spherical body in an oscillating liquid flow in a vertical axisymmetric channel of variable cross section is experimentally studied. It is shown that the oscillating liquid leads to the generation of intense averaged flows in each of the channel segments. The intensity and direction of these flows depend on the dimensionless oscillating frequency. In the region of studied frequencies, the dynamics of the considered body is examined when the primary vortices emerging in the flow occupy the whole region in each segment. For a fixed frequency, an increase in the… More >

Lihui Ma^1,*, Zhuo Han¹, Wei Li¹, Guangfeng Qi¹, Ran Cheng², Yuanyuan Wang¹, Xiangran Mi³, Xiaohan Zhang¹, Yunfei Li¹

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.6, pp. 1381-1392, 2024, DOI:10.32604/fdmp.2024.046405

Abstract When a gas-liquid two-phase flow (GLTPF) enters a parallel separator through a T-junction, it generally splits unevenly. This phenomenon can seriously affect the operation efficiency and safety of the equipment located downstream. In order to investigate these aspects and, more specifically, the so-called bias phenomenon (all gas and liquid flowing to one pipe, while the other pipe is a liquid column that fluctuates up and down), laboratory experiments were carried out by using a T-junction connected to two parallel vertical pipes. Moreover, a GLTPF prediction model based on the principle of minimum potential energy was… More >

Xiaochu Luo¹, Xiaobing Qi², Zhao Luo³, Zhonghao Li⁴, Ruiquan Liao¹, Xingkai Zhang^1,*

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.6, pp. 1233-1249, 2024, DOI:10.32604/fdmp.2023.045737

Abstract Conventional conductivity methods for measuring the void fraction in gas-liquid multiphase systems are typically affected by accuracy problems due to the presence of fluid flow and salinity. This study presents a novel approach for determining the void fraction based on a reciprocating dynamic conductivity probe used to measure the liquid film thickness under forced annular-flow conditions. The measurement system comprises a cyclone, a conductivity probe, a probe reciprocating device, and a data acquisition and processing system. This method ensures that the flow pattern is adjusted to a forced annular flow, thereby minimizing the influence of More >

Yehao Long, Jing Zhong^*, Tongdi Zhang, Li Chen, Lijun Zhang^*

CMC-Computers, Materials & Continua, Vol.79, No.3, pp. 3435-3453, 2024, DOI:10.32604/cmc.2024.051629

Abstract Physical Vapor Deposited (PVD) TiAlN coatings are extensively utilized as protective layers for cutting tools, renowned for their excellent comprehensive performance. To optimize quality control of TiAlN coatings for cutting tools, a multi-scale simulation approach is proposed that encompasses the microstructure evolution of coatings considering the entire preparation and service lifecycle of PVD TiAlN coatings. This scheme employs phase-field simulation to capture the essential microstructure of the PVD-prepared TiAlN coatings. Moreover, cutting simulation is used to determine the service temperature experienced during cutting processes at varying rates. Cahn-Hilliard modeling is finally utilized to consume the More >

Vladimir Ya. Modorskii, Ivan E. Cherepanov^*

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.5, pp. 1031-1043, 2024, DOI:10.32604/fdmp.2024.048494

Abstract A transition to clean hydrogen energy will not be possible until the issues related to its production, transportation, storage, etc., are adequately resolved. Currently, however, it is possible to use methane-hydrogen mixtures. Natural gas can be transported using a pipeline system with the required pressure being maintained by gas compression stations. This method, however, is affected by some problems too. Compressors emergency stops can be induced by vibrations because in some cases, mechanical methods are not able to reduce the vibration amplitude. As an example, it is known that a gas-dynamic flow effect in labyrinth… More >

Dongwei Wang^1,*, Lijian Cao¹, Weidong Wang², Jiajun Hu¹

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.5, pp. 1103-1122, 2024, DOI:10.32604/fdmp.2023.042654

Abstract A self-priming pump is a centrifugal pump that has the ability to prime itself. Typically, its performance depends on the configuration of its reflux hole. In this study, the ANSYS FLUENT software is used to investigate the effects of three different radial positions of the reflux hole on gas-liquid two-phase distribution, pressure pulsation, and imp during self-priming. The research results indicate that: (1) The effective channel size for the reflux liquid to enter the volute varies depending on the location of the reflux hole. The effect of the impeller rotation on the reflux liquid becomes… More >

Fangjin Lu^*†, Ying Zheng^‡, Paul Owusu Donkor^*, Peng Zou^§, Ping Mu^†

Oncology Research, Vol.24, No.3, pp. 171-179, 2016, DOI:10.3727/096504016X14634208142987

Abstract The cyclic-AMP response element-binding protein (CREB), a well-known nuclear transcription factor, has been shown to play an essential role in many cellular processes, including differentiation, cell survival, and cell proliferation, by regulating the expression of downstream genes. Recently, increased expression of CREB was frequently found in various tumors, indicating that CREB is implicated in the process of tumorigenesis. However, the effects of CREB on Hodgkin lymphoma (HL) remain unknown. To clarify the role of CREB in HL, we performed knockdown experiments in HL. We found that downregulation of CREB by short hairpin RNA (shRNA) resulted… More >

Hua Tao, Yiqin Zhou, Chengyun Yao, Dayong Gu, Wei Chen, Jincheng Lu

Oncology Research, Vol.25, No.8, pp. 1357-1362, 2017, DOI:10.3727/096504017X14889842609577

Abstract The aim of this study was to evaluate the efficacy and toxicity of intensity-modulated radiotherapy concurrent with weekly docetaxel in patients with node-positive esophageal squamous cell carcinoma after radical surgery. Between January 2011 and December 2013, a total of 46 eligible patients were enrolled. All patients received intensity-modulated radiotherapy concurrent with weekly docetaxel (20 mg/m² ). Patients were treated 5 days per week at 2.0 Gy/day. The total dose of external radiotherapy given was 50 Gy in 25 fractions. The primary endpoints included treatment completion and safety. The secondary endpoint was to assess whether the approach… More >

Makoto Akiyama^*†, Yoshihiro Sowa^*, Tomoyuki Taniguchi^*, Motoki Watanabe^*, Shingo Yogosawa^‡, Jo Kitawaki^†,Toshiyuki Sakai^*

Oncology Research, Vol.25, No.8, pp. 1245-1252, 2017, DOI:10.3727/096504017X14850164661097

Abstract Ovarian cancer is the most lethal disease among gynecological malignancies. More effective therapy is required to counter high recurrence rates and chemotherapy resistance. We investigated the efficacy and molecular mechanisms of three combined treatments (TCTs)—a novel histone deacetylase (HDAC) inhibitor OBP-801/YM753, 5-fluorouracil (5-FU), and paclitaxel (PTX)—in human ovarian cancer SKOV-3 and OVCAR-3 cells. The inhibition of cell growth was stronger with TCTs than with each single agent and with two combined treatments. The TCTs significantly induce G₂ phase arrest in both cell lines. We then analyzed the molecular mechanisms and found that the TCTs increased the More >

Julio C. Anchondo-Páez, Esteban Sánchez^*, Carlos A. Ramírez-Estrada, Alondra Salcido-Martínez, Erick H. Ochoa-Chaparro

Phyton-International Journal of Experimental Botany, Vol.93, No.5, pp. 963-980, 2024, DOI:10.32604/phyton.2024.048742

Abstract Beans contain a wide range of vitamins, proteins, calcium, and zinc which make them an important food source for many countries. To meet the demand for bean production worldwide, large amounts of fertilizers and pesticides are used. However, the cost of production and environmental impact increases. To produce food sustainably, the use of beneficial nutrients such as silicon as a biostimulant has been proposed. However, information about the effect of different sources of silicon on the metabolism of bean plants is scarce. Bean plants cv. Strike were grown in pots for 60 days and the… More >