JINXIA CHEN^1,2,3,#, SULI DAI^1,2,#, GENG ZHANG^4,5, SISI WEI^1,2, XUETAO ZHAO³, YANG ZHENG^1,2, YAOJIE WANG^1,2, XIAOHAN WANG^1,2, YUNJIANG LIU^4,5,*, LIANMEI ZHAO^1,2,*

Oncology Research, Vol.32, No.11, pp. 1791-1802, 2024, DOI:10.32604/or.2024.049348 - 16 October 2024

Abstract Background: Triple-negative breast cancer (TNBC) is a heterogeneous, recurring cancer characterized by a high rate of metastasis, poor prognosis, and lack of efficient therapies. KBU2046, a small molecule inhibitor, can inhibit cell motility in malignant tumors, including breast cancer. However, the specific targets and the corresponding mechanism of its function remain unclear. Methods: In this study, we employed (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H tetrazolium) (MTS) assay and transwell assay to investigate the impact of KBU2046 on the proliferation and migration of TNBC cells in vitro. RNA-Seq was used to explore the targets of KBU2046 that inhibit the motility of TNBC.… More > Graphic Abstract

Murad Njoum^1,2,*, Rossilawati Sulaiman¹, Zarina Shukur¹, Faizan Qamar¹

CMC-Computers, Materials & Continua, Vol.81, No.1, pp. 183-211, 2024, DOI:10.32604/cmc.2024.050090 - 15 October 2024

Abstract Random pixel selection is one of the image steganography methods that has achieved significant success in enhancing the robustness of hidden data. This property makes it difficult for steganalysts’ powerful data extraction tools to detect the hidden data and ensures high-quality stego image generation. However, using a seed key to generate non-repeated sequential numbers takes a long time because it requires specific mathematical equations. In addition, these numbers may cluster in certain ranges. The hidden data in these clustered pixels will reduce the image quality, which steganalysis tools can detect. Therefore, this paper proposes a… More >

Songnan Yang¹, Miao Zhang¹, Rongrong Yao¹, Liangyu Chen¹, Weixuan Cong¹, Dan Yao², Jian Zhang^1,3, Jun Zhang^1,*, Xueying Li^1,*

Phyton-International Journal of Experimental Botany, Vol.93, No.9, pp. 2209-2225, 2024, DOI:10.32604/phyton.2024.055046 - 30 September 2024

Abstract The high isoflavones content of soybeans is an important breeding goal due to the demonstrated benefits of isoflavones to human health and their association with plant resistance. In this study, quantitative trait loci (QTL) mapping for soybean isoflavone aglycones, including daidzin, glycerin, and genistin, and total isoflavones content was performed in a population of 178 F_2:6 recombinant inbred lines (RILs) which was generated from a cross between varieties Jinong 17 and Jinong 18. A genetic linkage map covering 1248 cM was constructed using the simple sequence repeat (SSR) molecular markers. The results revealed 22 isoflavone-related QTLs,… More >

Ahmad Nahar Quttoum^1,*, Muteb Alshammari²

CMC-Computers, Materials & Continua, Vol.80, No.3, pp. 4577-4601, 2024, DOI:10.32604/cmc.2024.054102 - 12 September 2024

Abstract Cloud Datacenter Network (CDN) providers usually have the option to scale their network structures to allow for far more resource capacities, though such scaling options may come with exponential costs that contradict their utility objectives. Yet, besides the cost of the physical assets and network resources, such scaling may also impose more loads on the electricity power grids to feed the added nodes with the required energy to run and cool, which comes with extra costs too. Thus, those CDN providers who utilize their resources better can certainly afford their services at lower price-units when… More >

Md. Mosiur Rahman^1,2, Md. Ruhul Quddus³, Quanle Xu⁴, Muhammad Malek Hossain², Rong Liu¹, Mengwei Li¹, Xin Yan¹, Guan Li¹, Yishan Ji¹, Chenyu Wang¹, Ashutosh Sarker⁵, Tao Yang¹, Xuxiao Zong¹, Md. Monoar Hossain⁶, Saleh Alfarraj⁷, Mohammad Javed Ansari⁸, Sagar Maitra^9,*, Akbar Hossain^10,*

Phyton-International Journal of Experimental Botany, Vol.93, No.8, pp. 1781-1804, 2024, DOI:10.32604/phyton.2024.048992 - 30 August 2024

Abstract Grass pea (Lathyrus sativus L.) is an imperative food crop cultured in dryland agricultural ecology. It is a vital source of dietary protein to millions of populaces living in low-income countries in South-East Asia and Africa. This study highlights the improvement of genomic properties and their application in marker-trait relationships for 17 yield-related characters in 400 grass pea genotypes from China and Bangladesh. These characters were assessed via 56 polymorphic markers using general linear model (GLM) (P+G+Q) and mixed linear model (MLM) (P+G+Q+K) in the tassel software based on the linkage disequilibrium and population structure analysis.… More >

Xuehui Jing¹, Junchen Guo¹, Zhiyun Wang^2,*

Frontiers in Heat and Mass Transfer, Vol.22, No.3, pp. 919-937, 2024, DOI:10.32604/fhmt.2024.049689 - 11 July 2024

Abstract In this paper, the combustion conditions in the boiler furnace of a 660 MW tangential fired pulverized coal boiler are numerically simulated at 15% and 20% rated loads, to study the flexibility of coal-fired power units on ultra-low load operation. The numerical results show that the boiler can operate safely at 15% and 20% ultra-low loads, and the combustion condition in the furnace is better at 20% load, and the tangent circles formed by each characteristic section in the furnace are better, and when the boiler load is decreased to 15%, the tangent circles in… More >

Md. Abdul Quddus¹, Md. Ataur Rahman¹, Razu Ahmed¹, Mohammad Eyakub Ali², Khokan Kumer Sarker³, Md. Alamgir Siddiky⁴, Mohibur Rahman⁴, Lamya Ahmed Alkeridis⁵, Samy Sayed^6,7, Ahmed Gaber^8,9, Akbar Hossain^10,*

Phyton-International Journal of Experimental Botany, Vol.93, No.5, pp. 901-922, 2024, DOI:10.32604/phyton.2024.049226 - 28 May 2024

Abstract Garden pea productivity and qualities are hampered in zinc (Zn), boron (B), and molybdenum (Mo) deficient soil. Thus, the combination of micronutrients (i.e., Zn, B, and Mo) and rhizobium is necessary to increase the productivity and quality of garden peas, since this management for garden peas is neglected in Bangladesh. Therefore, the present study was made to assess the effectiveness of rhizobium inoculant singly or in combination with the micronutrients (i.e., Zn, B, and Mo) on growth, yield, nutrient uptake, and quality of garden peas. Treatments were: T = Control, T = Rhizobium inoculation at 50… More >

Yuan Ren¹, Yingxian Sun¹, Zhiguang Yang², Yanli Chen^1,*

Congenital Heart Disease, Vol.19, No.2, pp. 157-176, 2024, DOI:10.32604/chd.2024.047930 - 16 May 2024

Abstract Chronic thromboembolic pulmonary hypertension (CTEPH) is a chronic, progressive, debilitating, and life-threatening complication of pulmonary embolism (PE). Recent technological advances have permitted various treatment options for the treatment of CTEPH, including surgery, angioplasty, and medical treatment, depending on the location and characteristics of lesions. Pulmonary endarterectomy (PEA) is the treatment of choice for CTEPH, as it offers excellent long-term outcomes and a high probability of recovery. Moreover, various medical and interventional therapies are currently being developed for patients with inoperable CTEPH. This review mainly summarizes the current treatment approaches of CTEPH, offering more options for More >

Muhammad Zaman Ali¹, Omer Riaz¹, Hafiz Muhammad Hasnain², Waqas Sharif², Tenvir Ali², Gyu Sang Choi^3,*

CMC-Computers, Materials & Continua, Vol.79, No.2, pp. 2923-2943, 2024, DOI:10.32604/cmc.2024.049139 - 15 May 2024

Abstract In today’s rapidly evolving landscape of communication technologies, ensuring the secure delivery of sensitive data has become an essential priority. To overcome these difficulties, different steganography and data encryption methods have been proposed by researchers to secure communications. Most of the proposed steganography techniques achieve higher embedding capacities without compromising visual imperceptibility using LSB substitution. In this work, we have an approach that utilizes a combination of Most Significant Bit (MSB) matching and Least Significant Bit (LSB) substitution. The proposed algorithm divides confidential messages into pairs of bits and connects them with the MSBs of… More >

Hui Du, Zhiyuan Hu^*, Depeng Lu, Jingrui Liu

CMC-Computers, Materials & Continua, Vol.79, No.2, pp. 3239-3259, 2024, DOI:10.32604/cmc.2024.046314 - 15 May 2024

Abstract Traditional clustering algorithms often struggle to produce satisfactory results when dealing with datasets with uneven density. Additionally, they incur substantial computational costs when applied to high-dimensional data due to calculating similarity matrices. To alleviate these issues, we employ the KD-Tree to partition the dataset and compute the K-nearest neighbors (KNN) density for each point, thereby avoiding the computation of similarity matrices. Moreover, we apply the rules of voting elections, treating each data point as a voter and casting a vote for the point with the highest density among its KNN. By utilizing the vote counts More >