XUEJIA ZHAI^1,2,3,4,#, JIE LIU^2,3,4,#, JINWEI XIAO^2,3,4, TAO ZHANG^2,3,4, JUN WANG^2,3,4,5, JIANJUN LI^1,*, SHICANG YU^2,3,4,5,*

BIOCELL, Vol.48, No.8, pp. 1223-1239, 2024, DOI:10.32604/biocell.2024.050803

Abstract Background: Protein lactylation is a new way for the “metabolic waste” lactic acid to perform novel functions. Nevertheless, our understanding of the contribution of protein lactylation to both tumor progression and therapeutic interventions remains imited. The construction of a scoring system for lactylation to predict the prognosis of pan-cancer patients and to evaluate the tumor immune microenvironment (TIME) would improve our understanding of the clinical significance of lactylation. Methods: Consensus clustering analysis of lactylation-related genes was used to cluster 177 pancreatic adenocarcinoma (PAAD) patients. Subsequently, a scoring system was developed using the least absolute shrinkage… More >

Jiawang Xiao, Jianming Wang, Zhongchao Wang, Lili Meng, Ming Zhao, Qiguang Wang^*

Congenital Heart Disease, Vol.19, No.3, pp. 293-303, 2024, DOI:10.32604/chd.2024.051427

Abstract Background: Transcatheter closure (TCC) has emerged as the preferred treatment for selected congenital heart disease (CHD). While TCC offers benefits for patients with postoperative residual shunts, understanding its mid- and long-term efficacy and safety remains crucial. Objective: This study aims to assess the mid- and long-term safety and efficacy of TCC for patients with residual atrial or ventricular septal shunts following CHD correction. Methods: In this consecutive retrospective study, we enrolled 35 patients with residual shunt who underwent TCC or surgical repair of CHD between June 2011 to October 2022. TCC candidacy was determined based on… More >

ANA S. CVETANOVIC^1,2,*, MATTEO LAMBERTINI^3,4, KEVIN PUNIE⁵, GORANA G. MATOVINA BRKO⁶, NIKOLA D. ZIVKOVIC^7,8, MAJA J. POPOVIC^6,9, MARIJANA M. MILOVIC KOVACEVIC¹⁰, LAZAR S. POPOVIC^6,9

Oncology Research, Vol.32, No.8, pp. 1309-1322, 2024, DOI:10.32604/or.2024.049743

Abstract Oncofertility is an extremely significant topic that is increasingly being discussed owing to increased evidence indicating that fertility preservation does not affect the treatment outcomes of patients with cancer but significantly contributes to preserving life quality. The effect of chemotherapy can range from minimal effects to complete ovarian atrophy. Limited data are available on the effects of monoclonal antibodies and targeted therapies on the ovaries and fertility. Temporary ovarian suppression by administering a gonadotropin-releasing hormone agonist (GnRHa) during chemotherapy decreases the gonadotoxic effect of chemotherapy, thereby diminishing the chance of developing premature ovarian insufficiency (POI).… More > Graphic Abstract

Romaissa Kebache¹, Abdelkader Laouid^1,*, Ahcene Bounceur², Mostefa Kara^1,3, Konstantinos Karampidis⁴, Giorgos Papadourakis⁴, Mohammad Hammoudeh²

Computer Systems Science and Engineering, Vol.48, No.4, pp. 1055-1072, 2024, DOI:10.32604/csse.2024.048738

Abstract Internet cloud services come at a price, especially when they provide top-tier security measures. The cost incurred by cloud utilization is directly proportional to the storage requirements. Companies are always looking to increase profits and reduce costs while preserving the security of their data by encrypting them. One of the offered solutions is to find an efficient encryption method that can store data in a much smaller space than traditional encryption techniques. This article introduces a novel encryption approach centered on consolidating information into a single ciphertext by implementing Multi-Key Embedded Encryption (MKEE). The effectiveness… More >

Abdullah A. Alharbi¹, Ahmad Y. Alqassim^1,*, Mohammed A. Muaddi¹, Najat H. Aldubayyan¹, Rana I. Abuhadi¹, Futon A. Akoor¹, Sarah J. Mobarki¹, Imtenan A. Oberi¹, Ghaidaa H. Alharbi¹, Yara Ajeebi¹, Adnan M. Alkhayat², Hafiz Malhan³, Mohammed Bakkar⁴, Anwar M. Makeen¹

International Journal of Mental Health Promotion, Vol.26, No.5, pp. 351-359, 2024, DOI:10.32604/ijmhp.2024.047219

Abstract Sickle Cell Anemia (SCA) is a prevalent genetic condition in Saudi Arabia, particularly in the Jazan region. The study’s purpose was to assess the prevalence of de-pression among individuals with SCA in this area and to identify the factors associated with this condition. The study involved 391 adult participants, all patients in the hematology center of Prince Mohammed bin Nasser Hospital (PMNH). Data was collected through an anonymous interview questionnaire–the Arabic version of the Patient Health Questionnaire-9 (PHQ-9)–between March–May 2022. The questionnaire covered socio-demographic information and variables related to the participant’s SCA history, such as… More >

Ketut Putu Yasa^1,2,*, Nyoman Satria Sadu Bhaskara², Putu Febry Krisna Pertiwi²

Congenital Heart Disease, Vol.19, No.2, pp. 139-156, 2024, DOI:10.32604/chd.2024.050348

Abstract Objective: Patients with ductal-dependent pulmonary circulation require alternative blood flow to provide and maintain adequate oxygenation. Modified Blalock-Taussig Shunt (MBTS) has been the standard for providing such a result. Currently, less invasive methods such as Arterial Duct (AD) stenting have been performed as alternatives. This study aims to compare the outcome of AD stenting and MBTS. Method: Systematic research was performed in online databases using the PRISMA protocol. The outcomes measured were 30-day mortality, complication, unplanned intervention, oxygen saturation, duration of hospital, and ICU length of stay. Any comparative study provided with full text is… More >

Ghazi A. Alshumrani^*

Congenital Heart Disease, Vol.19, No.2, pp. 197-206, 2024, DOI:10.32604/chd.2024.049401

Abstract Objective: Coronary artery anatomical variations and anomalies are an important topic due to their potential clinical manifestations. This study aims to investigate the prevalence of coronary artery anatomical variations and anomalies in symptomatic patients with coronary computed tomography angiography (CCTA). Methods: This is a retrospective study that included all symptomatic patients who had CCTA in a tertiary care hospital in Saudi Arabia during a period of seven years. Results: The total number of included patients was 507 (60% males) with a mean age of 57.4 years. Approximately 41% had luminal stenoses, averaging 49.7%. The total number… More >

YAN ZHANG, HEYANG ZHANG, JING WANG, XIN WEI, YI QU, FENG XU, LIJUN ZHANG^*

Oncology Research, Vol.32, No.5, pp. 955-963, 2024, DOI:10.32604/or.2023.043922

Abstract Background: Bortezomib results in peripheral neuropathy (PN) in approximately 50% of patients, during multiple myeloma (MM) treatment, a complication known as Bortezomib-induced peripheral neuropathy (BIPN). The drug response varies among individuals. Genetic factor may play an important role in BIPN. Methods: A next-generation sequencing (NGS) panel containing 1659 targets from 233 genes was used to identify risk variants for developing BIPN in 204 MM patients who received bortezomib therapy. mRNA expression of MTHFR and ALDH1A1 in 62 peripheral blood samples was detected by real-time quantitative PCR (RT-qPCR). Serum homocysteine (Hcy) levels were detected in 40 samples… More > Graphic Abstract

JIYU WANG^1,2, HUIXIA LI^1,2, DEYUAN ZHOU^1,2, LIHONG BAI^1,2, KEJING TANG^1,2,3,*

BIOCELL, Vol.48, No.4, pp. 623-637, 2024, DOI:10.32604/biocell.2024.030420

Abstract Background: For patients with lung cancer, timely identification of new lung lesions as infectious or non-infectious, and accurate identification of pathogens is very important in improving OS of patients. As a new auxiliary examination, metagenomic next-generation sequencing (mNGS) is believed to be more accurate in diagnosing infectious diseases in patients without underlying diseases, compared with conventional microbial tests (CMTs). We designed this study to find out whether mNGS has better performance in distinguishing infectious and non-infectious diseases in lung cancer patients using bronchoalveolar lavage fluid (BALF). Materials and Methods: This study was a real-world retrospective review… More >

Guilhem Paillard-Brunet^*, Audrey Couillet

Psycho-Oncologie, Vol.18, No.1, pp. 23-31, 2024, DOI:10.32604/po.2023.047888

Abstract Cette étude qualitative visait à recueillir chez les professionnels d’un Centre de Lutte Contre le Cancer les attentes et les réticences qu’ils pouvaient avoir vis-à-vis des interventions de pair-aidance. Des entretiens individuels semi-structurés ont été menés auprès de 12 professionnels issus de professions différentes. Une retranscription intégrale des entretiens puis une analyse thématique de leur contenu ont été conduites. L’analyse des données a permis de faire émerger trois thèmes principaux quant aux attentes exprimées par les soignants : le besoin d’un accompagnement plus soutenant des patients, rompre leur isolement dans la maladie et enrichir le More >