Yameng Yin¹, Lieping Zhang^2,*, Xiaoxu Shi¹, Yilin Wang³, Jiansheng Peng⁴, Jianchu Zou⁴

CMC-Computers, Materials & Continua, Vol.81, No.2, pp. 2769-2790, 2024, DOI:10.32604/cmc.2024.056791 - 18 November 2024

Abstract By integrating deep neural networks with reinforcement learning, the Double Deep Q Network (DDQN) algorithm overcomes the limitations of Q-learning in handling continuous spaces and is widely applied in the path planning of mobile robots. However, the traditional DDQN algorithm suffers from sparse rewards and inefficient utilization of high-quality data. Targeting those problems, an improved DDQN algorithm based on average Q-value estimation and reward redistribution was proposed. First, to enhance the precision of the target Q-value, the average of multiple previously learned Q-values from the target Q network is used to replace the single Q-value… More >

Yong Xu^1,2, Xuewei Zhang¹, Wenlong Xie^2,*, Shihong Zhang², Xinyue Huang³, Yaqiang Tian¹, Liansheng Chen¹

CMC-Computers, Materials & Continua, Vol.81, No.2, pp. 2753-2768, 2024, DOI:10.32604/cmc.2024.055408 - 18 November 2024

Abstract The design of the loading path is one of the important research contents of the tube hydroforming process. Optimization of loading paths using optimization algorithms has received attention due to the inefficiency of only finite element optimization. In this paper, the hydroforming process of 5A02 aluminum alloy variable diameter tube was as the research object. Fuzzy control was used to optimize the loading path, and the fuzzy rule base was established based on FEM. The minimum wall thickness and wall thickness reduction rate were determined as input membership functions, and the axial feeds variable value… More >

Kusum Yadav¹, Yasser Alharbi¹, Eissa Jaber Alreshidi¹, Abdulrahman Alreshidi¹, Anuj Kumar Jain², Anurag Jain³, Kamal Kumar⁴, Sachin Sharma⁵, Brij B. Gupta^6,7,8,*

CMC-Computers, Materials & Continua, Vol.81, No.2, pp. 2665-2683, 2024, DOI:10.32604/cmc.2024.053565 - 18 November 2024

Abstract In today’s world, image processing techniques play a crucial role in the prognosis and diagnosis of various diseases due to the development of several precise and accurate methods for medical images. Automated analysis of medical images is essential for doctors, as manual investigation often leads to inter-observer variability. This research aims to enhance healthcare by enabling the early detection of diabetic retinopathy through an efficient image processing framework. The proposed hybridized method combines Modified Inertia Weight Particle Swarm Optimization (MIWPSO) and Fuzzy C-Means clustering (FCM) algorithms. Traditional FCM does not incorporate spatial neighborhood features, making More >

MAHDI ABDOLI SHADBAD¹, BEHZAD BARADARAN^2,*

Oncology Research, Vol.32, No.12, pp. 1949-1958, 2024, DOI:10.32604/or.2024.051569 - 13 November 2024

Abstract Background: Glioblastoma remains a highly invasive primary brain malignancy with an undesirable prognosis. Growing evidence has shed light on the importance of microRNAs (miRs), as small non-coding RNAs, in tumor development and progression. The present study leverages the in-silico and in-vitro techniques to investigate the significance of hsa-miR-181a-5p and the underlying hsa-miR-181a-5p-meidated signaling pathway in glioblastoma development. Methods: Bioinformatic studies were performed on GSE158284, GSE108474 (REMBRANDT study), TCGA-GTEx, CCLE, GeneMANIA, Reactome, WikiPathways, KEGG, miRDB, and microT-CDS to identify the significance of hsa-miR-181a-5p and its underlying target. Afterward, the U373 cell line was selected and transfected with… More >

KURT SARTORIUS^1,2,3,*, BENN SARTORIUS⁴, CHERIE WINKLER⁵, ANIL CHUTURGOON², ANNA KRAMVIS¹, PING AN⁵, WEIGANG ZHANG⁶, YUNJIE LU^3,6,7,*

BIOCELL, Vol.48, No.11, pp. 1543-1567, 2024, DOI:10.32604/biocell.2024.055505 - 07 November 2024

Abstract Hepatitis B-associated hepatocellular carcinoma (HBV-HCC) remains an intractable high-mortality solid tumor cancer that accounted for 42% of global HCC cases in 2019. Despite some developments in systemic therapy, only a small subset of late-stage HCC patients responds positively to recently developed therapeutic innovations. MicroRNAs (miRNAs) act as an ancillary epigenetic system that can regulate genome expression in all cancer pathways including HCC. The molecular mechanisms of miRNA regulation in cancer pathogenesis offered researchers a new approach that was widely hoped would translate into miRNA-based drugs and diagnostics. Thirty years on, miRNA-based diagnostic and therapeutic agents… More >

PINGHUA TU, SHANSHAN WANG, KELAN DENG, XINJUN LI, ZHANLING WU^*

BIOCELL, Vol.48, No.11, pp. 1603-1612, 2024, DOI:10.32604/biocell.2024.054364 - 07 November 2024

Abstract Objectives: The antitumor effects of pyropheophorbide-α methyl ester-mediated photodynamic therapy (MPPa-PDT) were observed in several cancers. The objective of this investigation was to examine the antineoplastic efficacy of MPPa-PDT acting on lung carcinoma A549 cells and further elaborate mechanisms. Methods: The viability of A549 cells was examined with cell counting kit-8 after MPPa-PDT disposal. Hoechst 33342 staining, monodansylcadaverine (MDC) staining, and transmission electron microscopy were employed to observe apoptotic bodies and autophagic vesicles. Flow cytometry with Annexin V/propidium iodide (PI) labeling objectively assessed cell death. The expression of associated proteins, including Caspase-3, Beclin-1, LC-3II, and More > Graphic Abstract

BINGJIE LIN¹, XIAOBO YING², CHUANLING ZHANG^3,*, GUOJUN ZHANG^1,*

BIOCELL, Vol.48, No.11, pp. 1613-1623, 2024, DOI:10.32604/biocell.2024.053652 - 07 November 2024

Abstract Objectives: This study explores the protective effects of glycyrrhizic acid (GA) on sepsis-induced cellular damage and inflammation in acute lung injury (ALI), specifically through the modulation of the sirtuin 1 (SIRT1) and high mobility group box 1 (HMGB1) pathway. Methods: The study employed two experimental models: lipopolysaccharide (LPS)-induced BEAS-2B human lung epithelial cells and cecal ligation and puncture (CLP) rats, to simulate sepsis conditions. The cell model involved treatments with LPS, GA, control siRNA (si-NC), and SIRT1-specific siRNA (si-SIRT1). Evaluations included cell viability, apoptosis, and cytokine production. In the rat model, treatments included GA and… More >

Xinmeng Zha¹, Huilin Ren^1,*, Yi Xiong^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.3, pp. 1-1, 2024, DOI:10.32604/icces.2024.011371

Abstract Additive manufacturing of continuous fiber composites is an emerging field that enables the tunable mechanical performance of composite structure by flexibly controlling the spatial layout of continuous fibers. Transverse isotropic strengthening is advantageous property of continuous fiber, which is favorable to align with the principal stress orientation. However, the accuracy and efficiency of traditional methods for calculating principal stress field are unguaranteed due to the inherent complexity and variability of geometries, material properties, and operational conditions in additive manufacturing. Therefore, a machine learning-assisted path planning method is proposed to robustly and efficiently generate the continuous… More >

Xin Zhang^1,2, Xitao Zheng^1,2, Tiantian Yang³, Mingyu Song^1,2, Yuanyuan Tian⁴, Leilei Yan^1,2,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.3, pp. 1-1, 2024, DOI:10.32604/icces.2024.011277

Abstract Composite joints are widely used in machinery industries such as aviation, aerospace, and marine, where they transfer main loads as lightweight connectors. Recently, 3D printing with continuous fibers has relieved the required molds in composite manufacturing process and given flexibility to the design of robust composite joints. However, how the curved paths and variable hatch spaces affect the mechanical properties and failure modes of 3D-printed single-bolt composite joints with continuous fibers remains undisclosed. In this study, 3D printing has been introduced to fabricate three types of continuous fiber-reinforced single-bolt composite joints with different paths, including… More >

Huilin Ren^1,2, David W. Rosen², Yi Xiong^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.1, pp. 1-1, 2024, DOI:10.32604/icces.2024.010920

Abstract The advancement of continuous fiber-reinforced polymer additive manufacturing (CFRP-AM) enables the fabrication of structures with complex geometries and superior properties. However, current design methodologies consider toolpath design and structure optimization as separate stages, with toolpath design typically serving as a post-processing step after structure optimization. This sequential methodology limits the full exploitation of fiber reinforced polymer composites (FRPC) capabilities, particularly in achieving optimal structural integrity and manufacturability. In this paper, a manufacturing-oriented method is proposed for designing continuous FRPC structures, in which the structural layout and continuous fiber toolpaths are simultaneously optimized. The integrated design… More >