YONGJIAN HUANG, JINZHOU WANG, JIUHUA XU, NING RUAN^*

Oncology Research, Vol.32, No.11, pp. 1765-1776, 2024, DOI:10.32604/or.2024.045564 - 16 October 2024

Abstract Background: Despite significant advancements in the development of anticancer therapies over the past few decades, the clinical management of colorectal cancer remains a challenging task. This study aims to investigate the inhibitory effects of cancer-targeting liposomes against colorectal cancer. Materials and Methods: Liposomes consisting of 3β-[N-(N′, N′-dimethylamino ethane)carbamoyl]-cholesterol (DC-CHOL), cholesterol (CHOL), and dioleoylphosphatidylethanolamine (DOPE) at a molar ratio of 1:1:0.5 were created and used as carriers to deliver an apoptosis-inducing plasmid encoding the tumor necrosis factor-related apoptosis-inducing ligand (pTRAIL) gene, along with the toll-like receptor (TLR7) agonist Rsiquimod (R848). The rationale behind this design is that More > Graphic Abstract

JIJIE XIAO¹, HONG XIAO², YUJUN CAI³, JIANWEI LIAO¹, JUE LIU¹, LIN YAO¹, SHAOLIN LI^1,*

Oncology Research, Vol.32, No.4, pp. 691-702, 2024, DOI:10.32604/or.2023.030767 - 20 March 2024

Abstract Osteosarcoma is a malignant tumor originating from bone tissue that progresses rapidly and has a poor patient prognosis. Immunotherapy has shown great potential in the treatment of osteosarcoma. However, the immunosuppressive microenvironment severely limits the efficacy of osteosarcoma treatment. The dual pH-sensitive nanocarrier has emerged as an effective antitumor drug delivery system that can selectively release drugs into the acidic tumor microenvironment. Here, we prepared a dual pH-sensitive nanocarrier, loaded with the photosensitizer Chlorin e6 (Ce6) and CD47 monoclonal antibodies (aCD47), to deliver synergistic photodynamic and immunotherapy of osteosarcoma. On laser irradiation, Ce6 can generate More > Graphic Abstract

Mingxuan He¹, Yahui Zheng¹, Jiaming Shen¹, Jiawei Shi¹, Yongzheng Zhang¹, Yinghong Xiao^2,*, Jianfei Che^1,*

Journal of Renewable Materials, Vol.12, No.2, pp. 215-233, 2024, DOI:10.32604/jrm.2023.043659 - 11 March 2024

Abstract

The abuse of plastic food packaging has brought about severe white pollution issues around the world. Developing green and sustainable biomass packaging is an effective way to solve this problem. Hence, a chitosan/sodium alginate-based multilayer film is fabricated via a layer-by-layer (LBL) self-assembly method. With the help of superior interaction between the layers, the multilayer film possesses excellent mechanical properties (with a tensile strength of 50 MPa). Besides, the film displays outstanding water retention property (blocking moisture of 97.56%) and ultraviolet blocking property. Anthocyanin is introduced into the film to detect the food quality since

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