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    ARTICLE

    Alanine minimises hepatocyte injury after ischemia-reperfusion in an ex vivo rat liver model

    Berengere PAPEGAY1, *, Michaela STADLER1, Vincent Nuyens1, Isabelle SALMON2, Veronique KRUYS3, Jean G. BOOGAERTS1

    BIOCELL, Vol.38, No.1, pp. 25-32, 2014, DOI:10.32604/biocell.2014.38.025

    Abstract Ischemia-reperfusion injury is a determinant in liver injury occurring during surgery, ischemic states and multiple organ failure. The pre-existing nutritional status of the liver, i.e., fasting, might contribute to the extent of tissue injury. This study investigated whether alanine, an amino acid precursor of glucose, could protect ex vivo perfused livers of fasting rats from reperfusion injury. The portal vein was cannulated, the liver removed and perfused in a closed ex vivo system. Isolated livers were perfused either with glucose 1 g/L and 10 g/L, or with equal concentrations of alanine (n = 10 in… More >

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