Fabio Tamanini1, Tatiane Zucchini de Souza1, Creusa Sayuri Tahara Amaral1, Antônio José Felix Carvalho2, Eliane Trovatti1,*
Journal of Renewable Materials, Vol.12, No.7, pp. 1343-1354, 2024, DOI:10.32604/jrm.2024.052288
Abstract An innovative pharmaceutical form for administering melatonin, based on starch orodispersible film (ODF), was designed and prepared. The composition of the ODF included starch as the polymer matrix, the active drug melatonin, and a plasticizer. Melatonin, a natural hormone produced by the pineal gland in the brain, can be absorbed by passive diffusion across the mucous membrane, resulting in improved bioavailability when compared to conventional oral administration. This study shows a simple and efficient method for preparing melatonin-loaded orodispersible films with a physically stable and commercially viable matrix, suitable for use in the pharmaceutical industry.… More >
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