S.J. Mousavi^∗, M.H. Doweidar^∗,†, M. Doblaré^∗

Molecular & Cellular Biomechanics, Vol.10, No.1, pp. 1-25, 2013, DOI:10.3970/mcb.2013.010.001

Abstract Although there are several computational models that explain the trajectory that cells take during migration, till now little attention has been paid to the integration of the cell migration in a multi-signaling system. With that aim, a generalized model of cell migration and cell-cell interaction under multisignal environments is presented herein. In this work we investigate the spatio-temporal cell-cell interaction problem induced by mechano-chemo-thermotactic cues. It is assumed that formation of a new focal adhesion generates traction forces proportional to the stresses transmitted by the cell to the extracellular matrix. The cell velocity and polarization direction are calculated based on… More >

Jie Wu^∗,†, Yan Cai^‡, Shixiong Xu^§, Quan Long^¶, Zurong Ding^*, Cheng Dong^∗,||

Molecular & Cellular Biomechanics, Vol.9, No.2, pp. 95-126, 2012, DOI:10.3970/mcb.2012.009.095

Abstract The effects of vascular-disrupting treatments on normalization of tumor microvasculature and its microenvironmental flow were investigated, by mathematical modeling and numerical simulation of tumor vascular-disrupting and tumor haemodynamics. Four disrupting approaches were designed according to the abnormal characteristics of tumor microvasculature compared with the normal one. The results predict that the vascular-disrupting therapies could improve tumor microenvironment, eliminate drug barrier and inhibit metastasis of tumor cells to some extent. Disrupting certain types of vessels may get better effects. In this study, the flow condition on the networks with "vascular-disrupting according to flowrate" is the best comparing with the other three… More >

E. Shaik^∗, K.A. Hoffmann^∗, J-F. Dietiker^∗

Molecular & Cellular Biomechanics, Vol.4, No.1, pp. 41-54, 2007, DOI:10.3970/mcb.2007.004.041

Abstract A potential interaction between the local hemodynamics and the artery wall response has been suggested for vascular graft failure by intimal hyperplasia (IH). Among the various hemodynamic factors, wall shear stress has been implicated as the primary factor responsible for the development of IH. In order to explore the role of hemodynamics in the formation of IH in end-to-side anastomosis, computational fluid dynamics is employed. To validate the numerical simulations, comparisons with existing experimental data are performed for both steady and pulsatile flows. Generally, good agreement is observed with the velocity profiles whereas some discrepancies are found in wall shear… More >

Chenxi Xiong^1,2, Xianghe Peng^1,2,3, Chunwei Zhao^1,2,4, Ning Hu^1,5,6

CMC-Computers, Materials & Continua, Vol.31, No.1, pp. 65-86, 2012, DOI:10.3970/cmc.2012.031.065

Abstract A method to reduce the sedimentation of the ferromagnetic particles in magnetorheological fluids (MRFs) is studied with numerical simulation and experiment. It shows that, making use of the magnetic field generated by a permanent magnet put simply above an MRF, the sedimentation of the particles in the MRF can be reduced remarkably. The magnetic force on a ferromagnetic particle and that on a particle chain are computed with the finite element (FE) code ANSYS. It reveals that the magnetic force on a particle-chain is much larger than the sum of the magnetic force on each individual particle in the chain… More >

Y.J. Chen¹, N. Huber^1,2

CMC-Computers, Materials & Continua, Vol.29, No.1, pp. 1-14, 2012, DOI:10.3970/cmc.2012.029.001

Abstract Gear transmission is important in engineering due to its high efficiency in transferring both power and motion. As a surface phenomenon, wear may change the gear geometry, cause a non-uniform gear rate and increase dynamic effects, all of which can lead to reduced efficiency and even severe tooth failure. In numerical predictions of wear, the conventional method, where the contact pressure over the slip distance is integrated, will cause a computation bottle-neck. To obtain an accurate integration of the wear within the small, fast moving contact area, the finite element model needs to be meshed very finely, and the time… More >

Zhijian Qiu¹, Jinchi Lu¹, Ahmed Elgamal^1,*, Lei Su², Ning Wang³, Abdullah Almutairi¹

CMES-Computer Modeling in Engineering & Sciences, Vol.120, No.3, pp. 629-656, 2019, DOI:10.32604/cmes.2019.05759

Abstract The OpenSees computational platform has allowed unprecedented opportunities for conducting seismic nonlinear soil-structure interaction simulations. On the geotechnical side, capabilities such as coupled solid-fluid formulations and nonlinear incremental-plasticity approaches allow for representation of the involved dynamic/seismic responses. This paper presents recent research that facilitated such endeavors in terms of response of ground-foundation-structure systems using advanced material modeling techniques and high-performance computing resources. Representative numerical results are shown for large-scale soil-structure systems, and ground modification liquefaction countermeasures. In addition, graphical user interface enabling tools for routine usage of such 3D simulation environments are presented, as an important element in support of… More >

Ying Zhou^1,*, Peng Chen¹

CMES-Computer Modeling in Engineering & Sciences, Vol.120, No.3, pp. 759-777, 2019, DOI:10.32604/cmes.2019.04383

Abstract This paper proposes a novel three-dimensional (3D) isolation system for facilities and presents the numerical simulation approach for the isolated system under earthquake excitations and impact effect using the OpenSees (Open System for Earthquake Engineering Simulation) software frame work. The 3D isolators combine the quasi-zero stiffness (QZS) system in the vertical direction and lead rubber bearing in the horizontal direction. Considering the large aspect ratio of the isolated facility, linear viscous dampers are designed in the vertical direction to diminish the overturning effect. The vertical QZS isolation system is characterized by a cubic force-displacement relation, thus, no elements or materials… More >

Yang Liu^1,*, Yue Qiao², Tiange Li³

CMES-Computer Modeling in Engineering & Sciences, Vol.120, No.1, pp. 177-201, 2019, DOI:10.32604/cmes.2019.06338

Abstract This paper studies the effect of ice resistance on the icebreaking capacity and speed of an icebreaking vessel. We combine an improved Correct Smoothed Particle Method (CSPM) with a material low-speed collision fracture model to numerically simulate the continuous icebreaking and rolling process of crushed. Using this model, we investigate the icebreaking resistance and immersion resistance during the icebreaking process, taking into account the fluid (water) as the elastic boundary support and the fluid-solid coupling interaction. We compare the icebreaking resistance and broken ice fracture shapes obtained by the numerical calculation with the theoretical analytical results, and thus validate the… More >

Zhe Li¹, Fan Yang^1,*, Yaping Liu¹, Yukui Gao¹

CMES-Computer Modeling in Engineering & Sciences, Vol.120, No.1, pp. 157-175, 2019, DOI:10.32604/cmes.2019.05187

Abstract In this paper, we investigated the shot blast treatment for derusting application through finite element (FE) simulations with a large number of random shots. The element deletion technique based on dynamic failure criteria was used to model the removal of rust. The cohesive surface model with damage evolution was used to characterize the decohesion of the rust/substrate interface. The effects of various processing and material parameters on the derusting effectiveness were examined. The results show that the rate of derusting mainly depends on the shot size, velocity and impinging angle, with little relevance to the rust thickness. The spalling of… More >

Jie Wang¹, Wei Jiang^1,*, Qi Wang¹

CMES-Computer Modeling in Engineering & Sciences, Vol.118, No.2, pp. 377-395, 2019, DOI:10.31614/cmes.2019.01836

Abstract A elastic-plastic fatigue crack growth (FCG) finite element model was developed for predicting crack growth rate under cyclic load. The propagation criterion for this model was established based on plastically dissipated energy. The crack growth simulation under cyclic computation was implemented through the ABAQUS scripting interface. The predictions of this model are in good agreement with the results of crack propagation experiment of compact tension specimen made of 304 stainless steel. Based on the proposed model, the single peak overload retardation effect of elastic-plastic fatigue crack was analyzed. The results shows that the single peak overload will reduce the accumulation… More >