Xiaozhuo Xu^1,2, Yilin Huang^1,2, Xu Han^2,*

Congenital Heart Disease, Vol.19, No.2, pp. 233-246, 2024, DOI:10.32604/chd.2024.050231 - 16 May 2024

Abstract Background: Hypoplastic left heart syndrome (HLHS) is one of the most challenging congenital heart diseases in clinical treatment. In cardiac tissues, resident macrophages fulfill critical functions in maintaining a stable cardiac state and have strong regenerative capacity and organ specificity. However, the molecular mechanisms of macrophages in HLHS remained unclear. Methods: Single-nucleus RNA sequencing (snRNA-seq) data of HLHS and healthy control (donors) samples obtained from the Gene Expression Omnibus (GEO) database were normalized and clustered using the Seurat package. The “FindMarkers” function was used to screen differentially expressed genes (DEGs) between the HLHS and donor… More > Graphic Abstract

Ruyi Luo, Yanyan Hu^*, Tingshu He^*, Xiaodong Ma, Yongdong Xu

Journal of Renewable Materials, Vol.11, No.9, pp. 3485-3500, 2023, DOI:10.32604/jrm.2023.027592 - 20 July 2023

Abstract The measures of steam curing and early-strengthening agents to promote the precast components to reach the target strength quickly can bring different degrees of damage to the concrete. Based on this, the new nanomaterial CSH-the hydration product of cement effectively solves these measures’ disadvantages, such as excessive energy consumption, thermal stress damage, and the introduction of external ions. In this paper, the effect of CSH on the early strength of precast fly ash concrete components was investigated in terms of setting time, workability, and mechanical properties and analyzed at the microscopic level using hydration temperature, More >

KE JIA¹, FU-QING TAN², SHUANG-LI HAO^1,*, WAN-XI YANG^1,*

BIOCELL, Vol.46, No.11, pp. 2399-2413, 2022, DOI:10.32604/biocell.2022.022015 - 07 July 2022

Abstract The SRY-related high mobility group (HMG) box (SOX) transcription factors participate in many physiological processes of animal growth, development, and reproduction and are related to spermatogenesis in many species. However, the relationship between SOX and spermatogenesis in Eriocheir sinensis is rarely reported. Here, we studied the role of Es-SOX8 in the spermatogenesis of E. sinensis and its possible regulation mechanism. Immunofluorescence results demonstrated Es-SOX8 signal in both cytoplasm and nucleus of spermatogonia, spermatocytes as well as spermatids, but not in mature spermatozoa. Hematoxylin and eosin staining showed a significant increase in the number of spermatozoa with abnormal… More >

CHUYING ZHOU¹, MINEKO KENGAKU^1,2,*

BIOCELL, Vol.46, No.11, pp. 2357-2361, 2022, DOI:10.32604/biocell.2022.021050 - 07 July 2022

Abstract Neuronal migration is a fundamental process of mammalian brain development. In migrating neurons, the nuclear membrane protein Nesprin-2 has been shown to serve as an adaptor to pull the nucleus along microtubule tracks. Current evidence has shown that Nesprin-2 binds to both the minus-end-directed motor dynein as well as the plus-end-directed motor kinesin. However, translocation of neuronal nucleus has long been thought to be primarily driven by dynein motors. Intriguing questions could be raised about the role of kinesin in nuclear transport and how the activities of opposing motors are coordinated through interactions with Nesprin. More >

Anuj Sharma¹, Deepak Prashar², Arfat Ahmad Khan³, Faizan Ahmed Khan⁴, Settawit Poochaya^3,*

CMC-Computers, Materials & Continua, Vol.73, No.2, pp. 3629-3648, 2022, DOI:10.32604/cmc.2022.030879 - 16 June 2022

Abstract Leukaemia is a type of blood cancer that is caused by undeveloped White Blood Cells (WBC), and it is also called a blast blood cell. In the marrow of human bones, leukaemia is developed and is responsible for blood cell generation with leukocytes and WBC, and if any cell gets blasted, then it may become a cause of death. Therefore, the diagnosis of leukaemia in its early stages helps greatly in the treatment along with saving human lives. Subsequently, in terms of detection, image segmentation techniques play a vital role, and they turn out to… More >

YINGHUI WU^#, HONG ZHANG^#, QIANG WANG, SUOYUAN LI, JUN SHEN^*

BIOCELL, Vol.46, No.6, pp. 1363-1364, 2022, DOI:10.32604/biocell.2022.018360 - 07 February 2022

Abstract Transcription factor Brachyury, a protein containing 435 amino acids, has been widely investigated and reported in notochord differentiation and nucleus pulposus development. The crucial functions and underlying mechanisms by Brachyury are discussed in this paper, which suggests Brachyury can be developed into a potential novel target for the therapy of intervertebral disc degeneration. More >

Afiqah Halim¹, Wan Azani Mustafa^1,2,*, Wan Khairunizam Wan Ahmad¹, Hasliza A. Rahim², Hamzah Sakeran³

Oncologie, Vol.23, No.1, pp. 73-88, 2021, DOI:10.32604/Oncologie.2021.015154 - 30 March 2021

Abstract Cervical cancer is a cell disease in the cervix that develops out of control in the female body. The cervix links the vagina (birth canal) with the upper section of the uterus, which can only be found in the female body. This is the second leading cause of death among women around the world. However, cervical cancer is currently one of the most preventable cancers if early detection is identified. The effect of unidentified cancer may increase the risk of death when the cell disease spreads to other parts of the female anatomy (metastasize). The… More >

Yujie Bai^1,*, Youquan Huang³, Guangsheng Cao¹, Xiaohan Nan¹, Qingchao Cheng¹, Lei Wang², Tong Du⁴

Journal of Renewable Materials, Vol.9, No.4, pp. 651-669, 2021, DOI:10.32604/jrm.2021.014479 - 01 February 2021

Abstract This study analyzed the partial effect of carbon dioxide hydrate in reaction kettle experiments. The particle and bubble characteristics of the crystal nucleus during carbon dioxide hydrate decomposition were observed under the microscope. The results showed that in the temperature range of 0.5°C–3.5°C, the pressure range of 3 MPa– 5.5 MPa, phase characteristics in the reaction kettle changed in a complex fashion during carbon dioxide hydrate formation. During hydrate decomposition, numerous carbon dioxide bubbles were produced, mainly by precipitation at high temperatures or in the hydrate cage structure. The hydrate crystal nucleus initially exhibited fluidity More >

HAO WANG^1,2,#, FANG FANG^1,#, CHAOYI FANG¹, RUNSHENG ZHAO^1,*, SHAOXIAN WANG^1,*

BIOCELL, Vol.44, No.3, pp. 421-429, 2020, DOI:10.32604/biocell.2020.010257 - 22 September 2020

Abstract Stress is an inevitable interference factor that seriously affects health. Listening to music is an economical, noninvasive, and highly accepted tool for easing stress. However, physiological studies investigating the ability of music to reduce stress in daily life are limited. We established rat models of chronic immobilization stress (CIS) to observe changes in the hypothalamic arcuate nucleus (ARC) neurons involved in the regulation of food intake and the effect of comfortable classical music exposure. Twenty-one days of stress resulted in decreased food intake and delayed body weight gain; up-regulation of leptin receptor (Ob-R), cocaine- and… More >

Runze Zhao¹, Tingting Xia¹, Mengyue Wang¹, Fan Feng¹, Wanqian Liu^1,*, Li Yang^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 77-77, 2019, DOI:10.32604/mcb.2019.07155

Abstract This study was focus on the exploring the therapeutic function of lysyl oxidase (LOX) in rat nucleus pulposus (NP) cells in intervertebral disc degeneration (IVDD). To do this, a Sprague-Dawley (SD) rat caudal spine degeneration model was established by puncturing the Co5-6 disc. NP cells apoptosis and extracellular matrix (ECM) degeneration in IVDD were evaluated by real-time quantitative reverse transcription-polymerase chain reaction (RT-qPCR), Hematoxylin-Eosin (H&E) and immunofluorescence. Then, the therapeutic effect of LOX on IVDD was evaluated by histological staining. In vitro, the regulator effect of LOX on degenerate rat NP cell was explored. ECM… More >