MOHAMMAD-SADEGH LOTFI, FATEMEH B. RASSOULI^*

BIOCELL, Vol.48, No.10, pp. 1419-1428, 2024, DOI:10.32604/biocell.2024.053597 - 02 October 2024

Abstract Parkinson’s disease (PD) is one of the fastest-growing neurodegenerative disorders worldwide. So far, PD treatments only offer little clinical relief and cannot reverse or stop the disease progression. Stem cell (SC) therapy is a rapidly evolving technology that holds significant promise for enhancing current therapeutic approaches. Adipose-derived mesenchymal SCs (AD-MSCs) have many features such as easy harvest with minimal invasive techniques, high plasticity, non-immunogenicity, and no ethical issues, which have made them suitable choices for clinical applications in regenerative research. AD-MSCs are ideal tools to treat PD, as they have the potential to differentiate into… More >

Jingting Mei, Yang Yang^*, Zhipeng Gao, Lanlan Rui, Yijing Lin

CMC-Computers, Materials & Continua, Vol.79, No.3, pp. 4883-4904, 2024, DOI:10.32604/cmc.2024.051860 - 20 June 2024

Abstract Network fault diagnosis methods play a vital role in maintaining network service quality and enhancing user experience as an integral component of intelligent network management. Considering the unique characteristics of edge networks, such as limited resources, complex network faults, and the need for high real-time performance, enhancing and optimizing existing network fault diagnosis methods is necessary. Therefore, this paper proposes the lightweight edge-side fault diagnosis approach based on a spiking neural network (LSNN). Firstly, we use the Izhikevich neurons model to replace the Leaky Integrate and Fire (LIF) neurons model in the LSNN model. Izhikevich… More >

VIRAAJ VISHNU PRASAD, JENNIFER SALLY SAMSON, VENKATACHALAM DEEPA PARVATHI^*

BIOCELL, Vol.48, No.5, pp. 693-706, 2024, DOI:10.32604/biocell.2024.048776 - 06 May 2024

Abstract Physical activity and exercise have several beneficial roles in enhancing both physiological and psychological well-being of an individual. In addition to aiding the regulation of aerobic and anaerobic metabolism, exercise can stimulate the synthesis of exerkine hormones in the circulatory system. Among several exerkines that have been investigated for their therapeutic potential, Brain-derived neurotrophic factor (BDNF) is considered the most promising candidate, especially in the management of neurodegenerative diseases. Owing to the ability of physical activity to enhance BDNF synthesis, several experimental studies conducted so far have validated this hypothesis and produced satisfactory results at More > Graphic Abstract

Muhammad Umar Nasir¹, Omar Kassem Khalil², Karamath Ateeq³, Bassam SaleemAllah Almogadwy⁴, M. A. Khan⁵, Khan Muhammad Adnan^6,*

CMC-Computers, Materials & Continua, Vol.79, No.1, pp. 963-981, 2024, DOI:10.32604/cmc.2024.047874 - 25 April 2024

Abstract Cervical cancer is an intrusive cancer that imitates various women around the world. Cervical cancer ranks in the fourth position because of the leading death cause in its premature stages. The cervix which is the lower end of the vagina that connects the uterus and vagina forms a cancerous tumor very slowly. This pre-mature cancerous tumor in the cervix is deadly if it cannot be detected in the early stages. So, in this delineated study, the proposed approach uses federated machine learning with numerous machine learning solvers for the prediction of cervical cancer to train… More >

JIANHUA LI^1,#, YAOGANG ZHANG^1,2,#, TAO ZHANG³, MEIYUAN TIAN¹, JING HOU¹, DENGLIANG HUANG¹, YAN CHENG^1,3, ZHU MAN^1,3, XIAOMING SU^1,3, ZHIQIN LI¹, SIXIAN TONG¹, XUAN ZHANG^1,3, JUN DENG^1,3, YUN DONG^1,3, YANYAN MA^1,2,3,*

BIOCELL, Vol.44, No.2, pp. 209-215, 2020, DOI:10.32604/biocell.2020.08941 - 27 May 2020

Abstract The aim of this study was to find a way to efficiently separate neuronal cells from the cerebral cortex of adult rats, providing a reference method for rapid acquisition of neuronal cells from the adult rat brain. Fifteen SD rats were randomly divided into three groups, with five SD rats in each group. Then, neuron cells were isolated from the adult rat cerebral cortex by the grinding method, the trypsin method, and the collagenase II method, respectively. The expression of anti-NeuN in the neurons of each group was analyzed by flow cytometry. The acquisition rates More >

A. M. E. Ramírez-Mendoza¹

CMES-Computer Modeling in Engineering & Sciences, Vol.115, No.3, pp. 295-311, 2018, DOI:10.3970/cmes.2018.00239

Abstract A spike response model (SRM) based on the spikes generator circuit (SGC) of adaptive fuzzy spiking neurons (AFSNs) is developed. The SRM is simulated in MatlabTM environment. The proposed model is applied to a configuration of a fuzzy exclusive or (fuzzy XOR) operator, as an illustrative example. A description of the comparison of AFSNs with other similar methods is given. The novel method of the AFSNs is used to determine the value of the weights or parameters of the fuzzy XOR, first with dynamic weights or self-tuning parameters that adapt continuously, then with fixed weights More >

Solange Marta Franzói De MORAES, Thais Andréia BROGIO, Jacqueline Nelisis ZANONi, Mariana Cristina Vicente Umada ZAPATER, Sidney Barnabé PEREs, Luzmarina HERNANDES

BIOCELL, Vol.37, No.2, pp. 37-43, 2013, DOI:10.32604/biocell.2013.37.037

Abstract Creatine is widely used by athletes as an ergogenic resource. The aim of this study was to evaluate the influence of creatine supplementation on the duodenum of rats submitted to physical training. The number and myenteric neuronal cell bodies as well mucosal and muscular tunic morphometry were evaluated. Control animals received a standard chow for 8 weeks, and the treated ones received the standard chow for 4 weeks and were later fed with the same chow but added with 2% creatine. Animals were divided in groups: sedentary, sedentary supplemented with creatine, trained and trained supplemented… More >

ORLANDO J. CASTEJÓN^1*, MICHAEL E. DAILEY²

BIOCELL, Vol.33, No.2, pp. 71-80, 2009, DOI:10.32604/biocell.2009.33.071

Abstract The localization of GluR1 subunits of ionotropic glutamate receptors in the glial cells and inhibitory neurons of cerebellar cortex and their association with the climbing and parallel fibers, and basket cell axons were studied. Samples of P14 and P21 rat cerebellar cortex were exposed to a specific antibody against GluR1 subunit(s) of AMPA receptors and were examined with confocal laser scanning microscopy. GluR1 strong immunoreactivity was confined to Purkinje cell and the molecular layer. Weak GluR1 immunoreactivity was observed surrounding some Golgi cells in the granule cell layer. Intense GluR1 immunoreactivity was localized around Purkinje,… More >

JOÃO PAULO FERREIRA SCHOFFEN, MARIA RAQUEL MARÇAL NATALI

BIOCELL, Vol.31, No.1, pp. 33-39, 2007, DOI:10.32604/biocell.2007.31.033

Abstract Alterations in the gastrointestinal neuromuscular function related to age have been demonstrated in human and animal models. This study analyzes the effects of the aging process on the area of the neuronal cell bodies of the myenteric plexus in the antimesenteric and intermediate regions of the ileal circumference of Wistar, 12 month-old in comparison 3 month-old animals. The ileum was removed and wholemount preparations immunostained by the antibody anti-myosin-V were processed. The morphometric analyses were performed using a computerized image analysis system, with a subsequent distribution of neurons by size in intervals of 100 μm². The More >

MARLI APARECIDA DOS SANTOS PEREIRA, MARIA CLAÚDIA BAGATIN, JACQUELINE NELISIS ZANONI

BIOCELL, Vol.30, No.2, pp. 295-300, 2006, DOI:10.32604/biocell.2006.30.295

Abstract We assessed the ascorbic acid (AA) supplementation on the myenteric neurons in the duodenum of rats. Fifteen rats with 90 days of age were divided into three groups: control (C), diabetics (D) and ascorbic acid treated diabetics (DA). After 120 days of daily treatment with AA, the duodenum was submitted to the NADH-diaphorase (NADH-d) histochemical technique, which allowed us to evaluate the neuronal density in an area of 8.96 mm² for each duodenum, and also to measure the cellular profile area of 500 neurons per group. The supplementation promoted an increase on AA levels. The neuronal More >