ZHEN WANG¹, JUN FU¹, SAISAI ZHU¹, HAODONG TANG², KUI SHI¹, JIHUA YANG³, MENG WANG³, MENGGE WU¹, DUNFENG QI^1,*

Oncology Research, Vol.32, No.12, pp. 1851-1866, 2024, DOI:10.32604/or.2024.055286 - 13 November 2024

Abstract Background: Pancreatic ductal adenocarcinoma (PDAC) has a rich and complex tumor immune microenvironment (TIME). M2 macrophages are among the most extensively infiltrated immune cells in the TIME and are necessary for the growth and migration of cancers. However, the mechanisms and targets mediating M2 macrophage infiltration in pancreatic cancer remain elusive. Methods: The M2 macrophage infiltration score of patients was assessed using the xCell algorithm. Using weighted gene co-expression network analysis (WGCNA), module genes associated with M2 macrophages were identified, and a predictive model was designed. The variations in immunological cell patterns, cancer mutations, and… More > Graphic Abstract

MOHD ATHAR^1,*, ANU MANHAS², NISARG RANA², AHMAD IRFAN³

BIOCELL, Vol.48, No.6, pp. 935-944, 2024, DOI:10.32604/biocell.2024.049891 - 10 June 2024

Abstract Computational methods have significantly transformed biomedical research, offering a comprehensive exploration of disease mechanisms and molecular protein functions. This article reviews a spectrum of computational tools and network analysis databases that play a crucial role in identifying potential interactions and signaling networks contributing to the onset of disease states. The utilization of protein/gene interaction and genetic variation databases, coupled with pathway analysis can facilitate the identification of potential drug targets. By bridging the gap between molecular-level information and disease understanding, this review contributes insights into the impactful utilization of computational methods, paving the way for More >

Xindi Huang¹, Liwei Liang¹, Sakirin Tam², Hao Liang³, Xiong Cai⁴, Changsong Ding^1,5,*

Computer Systems Science and Engineering, Vol.48, No.3, pp. 691-704, 2024, DOI:10.32604/csse.2022.029970 - 20 May 2024

Abstract Chinese Medicine (CM) has been widely used as an important avenue for disease prevention and treatment in China especially in the form of CM prescriptions combining sets of herbs to address patients’ symptoms and syndromes. However, the selection and compatibility of herbs are complex and abstract due to intrinsic relationships between herbal properties and their overall functions. Network analysis is applied to demonstrate the complex relationships between individual herbal efficacy and the overall function of CM prescriptions. To illustrate their connections and correlations, prescription function (PF), prescription herb (PH), and herbal efficacy (HE) intra-networks are… More >

CHAO LIU^*

BIOCELL, Vol.48, No.2, pp. 339-351, 2024, DOI:10.32604/biocell.2023.047044 - 23 February 2024

Abstract Introduction: Osteoarthritis (OA) is still an important health problem, and understanding its pathological mechanisms is essential for its diagnosis and treatment. There is evidence that autophagy may play a role in OA progression, but the exact mechanism remains unclear. Methods: In this study, we adopted a multi-prong approach to systematically identify the key autophagy-related genes (ARGs) associated with OA. Through weighted gene co-expression network analysis, we initially identified significant gene modules associated with OA. Subsequent differential gene analysis performed on normal and OA specimens. Further analysis later using the MCC algorithm highlighted hub ARGs. These… More >

JINFANG HU^1,#, JIANGEN AO^2,#, LONGSHENG FU^1,#, YAOQI WU¹, FENG SHAO³, TIANTIAN XU¹, MINGJIN JIANG⁴, SHAOFENG XIONG¹, YANNI LV^1,*

BIOCELL, Vol.47, No.7, pp. 1611-1622, 2023, DOI:10.32604/biocell.2023.028684 - 21 June 2023

Abstract Background: The attenuation function of Dalbergia odorifera leaves on cerebral ischemia-reperfusion (I/R) is little known. The candidate targets for the Chinese herb were extracted from brain tissues through the high-affinity chromatography. The molecular mechanism of D. odorifera leaves on cerebral I/R was investigated. Methods: Serial affinity chromatography based on D. odorifera leaves extract (DLE) affinity matrices were applied to find specific binding proteins in the brain tissues implemented on C57BL/6 mice by intraluminal middle cerebral artery occlusion for 1 h and reperfusion for 24 h. Specific binding proteins were subjected to mass-spectrometry to search for the differentially expressed… More >

CAN CHEN^#, RUI FENG^#, ZONGQIONG ZHANG^#, XIUZHONG XIA, BAOXUAN NONG, YU ZENG, HUI GUO, XINGHAI YANG^*, DANTING LI^*

BIOCELL, Vol.47, No.2, pp. 409-421, 2023, DOI:10.32604/biocell.2023.023543 - 18 November 2022

Abstract Plant height (PH) is a complex trait regulated by the environment and multiple genes. PH directly affects crop yield, harvest index, and lodging resistance. From plant dwarf mutants, many genes related to PH have been identified and described. Nonetheless, the molecular mechanism of height regulation in high-culm rice mutants has not been well studied. By using transcriptome and weighted gene co-expression network analysis (WGCNA), we identified the differentially expressed genes (DEGs) between high-culm rice mutants (MUT) and wild-type (WT) and explored the key pathways and potential candidate genes involved in PH regulation. Transcriptome analysis identified… More >

Ayodeji O. J Ibitoye^1,*, Olufade F. W Onifade²

Journal on Big Data, Vol.4, No.2, pp. 87-95, 2022, DOI:10.32604/jbd.2022.024533 - 31 October 2022

Abstract Community based churn prediction, or the assignment of recognising the influence of a customer’s community in churn prediction has become an important concern for firms in many different industries. While churn prediction until recent times have focused only on transactional dataset (targeted approach), the untargeted approach through product advisement, digital marketing and expressions in customer’s opinion on the social media like Twitter, have not been fully harnessed. Although this data source has become an important influencing factor with lasting impact on churn management. Since Social Network Analysis (SNA) has become a blended approach for churn… More >

Farhan Amin, Gyu Sang Choi^*

CMC-Computers, Materials & Continua, Vol.73, No.3, pp. 6367-6391, 2022, DOI:10.32604/cmc.2022.029927 - 28 July 2022

Abstract The Internet of Things (IoT) has the potential to be applied to social networks due to innovative characteristics and sophisticated solutions that challenge traditional uses. Social network analysis (SNA) is a good example that has recently gained a lot of scientific attention. It has its roots in social and economic research, as well as the evaluation of network science, such as graph theory. Scientists in this area have subverted predefined theories, offering revolutionary ones regarding interconnected networks, and they have highlighted the mystery of six degrees of separation with confirmation of the small-world phenomenon. The… More >

JUNXIA LIU¹, KE PANG², FEI HE^2,*

BIOCELL, Vol.46, No.7, pp. 1661-1673, 2022, DOI:10.32604/biocell.2022.018023 - 17 March 2022

Abstract Breast cancer is one of the most common cancers in the world and seriously threatens the health of women worldwide. Prognostic models based on immune-related genes help to improve the prognosis prediction and clinical treatment of breast cancer patients. In the study, we used weighted gene co-expression network analysis to construct a co-expression network to screen out highly prognostic immune-related genes. Subsequently, the prognostic immune-related gene signature was successfully constructed from highly immune-related genes through COX regression and LASSO COX analysis. Survival analysis and time receiver operating characteristic curves indicate that the prognostic signature has More >

Tengfei Tu^1,2, Wei Yin³, Hua Zhang^1,2,*, Xingyu Zeng¹, Xiaoxiang Deng¹, Yuchen Zhou¹, Xu Liu⁴

CMC-Computers, Materials & Continua, Vol.71, No.2, pp. 2315-2331, 2022, DOI:10.32604/cmc.2022.022540 - 07 December 2021

Abstract The Internet Control Message Protocol (ICMP) covert tunnel refers to a network attack that encapsulates malicious data in the data part of the ICMP protocol for transmission. Its concealment is stronger and it is not easy to be discovered. Most detection methods are detecting the existence of channels instead of clarifying specific attack intentions. In this paper, we propose an ICMP covert tunnel attack intent detection framework ICMPTend, which includes five steps: data collection, feature dictionary construction, data preprocessing, model construction, and attack intent prediction. ICMPTend can detect a variety of attack intentions, such as… More >