Jae Hong Lee¹, Sungkyu Cho^2,*, Jae Gun Kwak², Hye Won Kwon², Woong-Han Kim², Mi Kyoung Song³, Sang-Yun Lee³, Gi Beom Kim³, Eun Jung Bae³

Congenital Heart Disease, Vol.19, No.1, pp. 69-83, 2024, DOI:10.32604/chd.2024.045137

Abstract Background: The optimal surgical timing and clinical outcomes of ventricular septal defect (VSD) closure in neonates remain unclear. We aimed to evaluate the clinical outcomes of VSD closure in neonates (age ≤ 30 days). Methods: We retrospectively reviewed 50 consecutive neonates who underwent VSD closure for isolated VSDs between August 2003 and June 2021. Indications for the procedure included congestive heart failure/failure to thrive and pulmonary hypertension. Major adverse events (MAEs) were defined as the composite of all-cause mortality, reoperation, persistent atrioventricular block, and significant (≥grade 2) valvular dysfunction. Results: The median age and body weight at operation were 26.0… More >

Hafza Ayesha Siddiqa¹, Muhammad Irfan¹, Saadullah Farooq Abbasi^2,*, Wei Chen¹

CMC-Computers, Materials & Continua, Vol.77, No.2, pp. 1759-1778, 2023, DOI:10.32604/cmc.2023.041970

Abstract Automatic sleep staging of neonates is essential for monitoring their brain development and maturity of the nervous system. EEG based neonatal sleep staging provides valuable information about an infant’s growth and health, but is challenging due to the unique characteristics of EEG and lack of standardized protocols. This study aims to develop and compare 18 machine learning models using Automated Machine Learning (autoML) technique for accurate and reliable multi-channel EEG-based neonatal sleep-wake classification. The study investigates autoML feasibility without extensive manual selection of features or hyperparameter tuning. The data is obtained from neonates at post-menstrual age 37 ± 05 weeks.… More >

François-Xavier Van Vyve¹, Karlien Carbonez², Jelena Hubrechts², Geoffroy de Beco¹, Jean E. Rubay¹, Mona Momeni³, Thierry Detaille⁴, Alain J. Poncelet^1,*

Congenital Heart Disease, Vol.18, No.5, pp. 539-550, 2023, DOI:10.32604/chd.2023.042344

Abstract Objectives: Over the last decade, neonatal repair has been advocated for many congenital heart diseases. However, specific subgroups of complex congenital heart disease still require temporary palliation for which both surgical and endovascular techniques are currently available. We reviewed our institutional experience with shunt palliation with an emphasis on risk factors for early mortality. Methods: This is a single-center retrospective study on 175 patients undergoing surgery for central shunt or modified Blalock-Taussig shunt. All data were extracted from a prospectively collected computerized database. We identified risk factors for early mortality by uni- and multi-variable analysis. All data were censored at… More >

François-Xavier Van Vyve^1,#, Karlien Carbonez^2,#, Geoffroy de Beco¹, Stéphane Moniotte², Jean E. Rubay¹, Mona Momeni³, Laurent Houtekie⁴, Alain J. Poncelet^1,*

Congenital Heart Disease, Vol.18, No.5, pp. 525-537, 2023, DOI:10.32604/chd.2023.042341

Abstract Objective: Despite increasing enthusiasm for neonatal repair, patients with ductal-dependent circulation (pulmonary/systemic) or restrictive pulmonary blood flow still require initial palliation. Ductal stenting has emerged as an endovascular approach whereas modified-Blalock-Taussig and central shunt remain surgical references. In this study, we analyzed the relationship between pulmonary artery growth, sites of shunt connection, or antegrade pulmonary blood flow in surgically placed shunts. The need for secondary catheter-based interventions or pulmonary arterioplasty was also investigated. Methods: A retrospective single-center study analyzing 175 patients undergoing surgery for a central or modified-Blalock-Taussig shunt. Outcome growth variables were right pulmonary artery/left pulmonary artery diameters/Z scores,… More > Graphic Abstract

Henry P. Foote¹, Huali Wu², Stephen J. Balevic^1,2, Elizabeth J. Thompson^1,2, Kevin D. Hill^1,2, Eric M. Graham³, Christoph P. Hornik^1,2, Karan R. Kumar^1,2,*

Congenital Heart Disease, Vol.18, No.3, pp. 295-313, 2023, DOI:10.32604/chd.2023.026262

Abstract Background: Infants undergoing cardiac surgery with cardiopulmonary bypass (CPB) frequently receive intra-operative methylprednisolone (MP) to suppress CPB-related inflammation; however, the optimal dosing strategy and efficacy of MP remain unclear. Methods: We retrospectively analyzed all infants under 90 days-old who received intra-operative MP for cardiac surgery with CPB from 2014–2017 at our institution. We combined real-world dosing data from the electronic health record (EHR) and two previously developed population pharmacokinetic/pharmacodynamic models to simulate peak concentration (Cmax) and area under the concentration-time curve for 24 h (AUC24) for MP and the inflammatory cytokines interleukin-6 (IL-6) and interleukin-10 (IL-10). We evaluated the relationships… More > Graphic Abstract

Alain J. Poncelet^1,*, Maureen Peers de Nieuwburgh², Stéphane Moniotte², Geoffroy de Beco¹, Karlien Carbonez², Jean E. Rubay¹, Thierry Detaille³, Laurent Houtekie³, Mona Momeni⁴

Congenital Heart Disease, Vol.18, No.2, pp. 151-168, 2023, DOI:10.32604/chd.2023.022636

Abstract Background: Most outcome studies in congenital cardiac surgery for “low weight” neonates include patients undergoing surgery without cardiopulmonary bypass (CPB). The primary objective of our study was to identify risk factors for in-hospital mortality in neonates weighing less than 3 Kg and undergoing surgery with CPB. In addition, we compared the effect of early surgery with CPB (before 37W-gestational age (GA)) for congenital heart disease to delayed surgery until a corrected GA of 37 weeks in an attempt to promote weight gain. Methods: Retrospective single-center study including all patients operated between 1997 and 2017. Uni- and multivariable analysis were used… More >

Ali Kheradmand¹, Sahar Ashrafzadeh², Farzane Rouzegari³, Samin Aliakbarian¹, Ali Naseh^4,*

International Journal of Mental Health Promotion, Vol.25, No.2, pp. 265-274, 2023, DOI:10.32604/ijmhp.2023.024773

Abstract Drug abuse by pregnant women is one of the significant problems for mothers and their neonates. This study aimed to investigate the effects of maternal substance use disorder during pregnancy on neonatal developmental criteria. In a case-control study, clinical records of 90 neonates diagnosed with neonatal abstinence syndrome who were admitted to NICU in one of four hospitals affiliated with Shahid-Beheshti University of Medical Sciences in Tehran, Iran between 2017 and 2020 were compared to 90 neonates without neonatal abstinence syndrome (control group). Demographic information and data for neonatal developmental characteristics and complications were extracted from the clinical records of… More >

Alyssia Venna¹, Kathleen Reid², Sarah Davis², Jiaxiang Gai³, Yves d’Udekem¹, Sarah Clauss^2,*

Congenital Heart Disease, Vol.17, No.5, pp. 505-518, 2022, DOI:10.32604/chd.2022.021571

Abstract Background: Patients with single ventricle anatomy are at increased risk of growth failure and malnutrition. Amongst cardiac centers, there is little standardization of feeding practices in this complex population. We hypothesized that initiation of our center’s preoperative feeding protocol would result in decreased gastrostomy tube (G-tube) use, decreased length of stay and would not result in increased Necrotizing Enterocolitis (NEC) rates. Methods: A single institution review of 52 patients who had undergone stage I single ventricle palliative repair was performed. Patient diagnoses were hypoplastic left heart syndrome (39%), atrioventricular canal (15%), and other (46%). Postoperative parameters such as time to… More > Graphic Abstract

Eszter Vojcek^1,2,*, V. Anna Gyarmathy^3,4, Rozsa Graf⁵, Anna M. Laszlo⁶, Laszlo Ablonczy⁷, Zsolt Prodan⁷, Istvan Seri^1,8

Congenital Heart Disease, Vol.17, No.4, pp. 447-461, 2022, DOI:10.32604/chd.2022.022274

Abstract Objective: Neonates with congenital heart disease (CHD) and perinatal stroke have high mortality and survivors are at risk for poor long-term neurodevelopmental outcome. The aim of this study was to assess the risk factors and outcome of neonates with both CHD and MRI-confirmed perinatal stroke (Study Group) and compare those to the risk factors and outcome of infants matched for CHD without stroke (Control-1) and of infants matched for MRI-confirmed stroke without CHD (Control-2). Methods: We conducted a population-based case-control study enrolling 28 term neonates with CHD and MRI-confirmed acute perinatal stroke born between 2007–2017 in the Central-Hungarian Region. Each… More > Graphic Abstract

Evan Pagano¹, Benjamin Frank¹, James Jaggers², Mark Twite³, Tracy T. Urban⁴, Jelena Klawitter^2,#, Jesse Davidson^1,#,*

Congenital Heart Disease, Vol.15, No.4, pp. 251-265, 2020, DOI:10.32604/CHD.2020.012219

Abstract Objectives: (1) To measure the global shift in the metabolome in hypoxemic versus non-hypoxemic infants with congenital heart disease; (2) To identify metabolites and metabolic pathways that are altered in hypoxemia. Study Design: Analysis of serum samples obtained prior to cardiopulmonary bypass from 82 infants ≤120 days old with congenital heart disease requiring surgery at Children’s Hospital Colorado. Infants were divided into groups based on preoperative oxygen saturations: non-hypoxemic (>92%), mild hypoxemia (85–92%), and severe hypoxemia (<85%). Tandem mass spectrometry was used to analyze 165 targeted metabolites. Partial least squares discriminant analysis and t-tests were used to determine differences among… More >