Jiahui Liu^1,2, Lang Li^1,2,*, Di Li^1,2, Yu Ou^1,2

CMC-Computers, Materials & Continua, Vol.79, No.3, pp. 4641-4657, 2024, DOI:10.32604/cmc.2024.051613

Abstract Correlation power analysis (CPA) combined with genetic algorithms (GA) now achieves greater attack efficiency and can recover all subkeys simultaneously. However, two issues in GA-based CPA still need to be addressed: key degeneration and slow evolution within populations. These challenges significantly hinder key recovery efforts. This paper proposes a screening correlation power analysis framework combined with a genetic algorithm, named SFGA-CPA, to address these issues. SFGA-CPA introduces three operations designed to exploit CPA characteristics: propagative operation, constrained crossover, and constrained mutation. Firstly, the propagative operation accelerates population evolution by maximizing the number of correct bytes… More >

Lili Bai^1,*, Wenhui Li¹, He Ren^1,2, Feng Li¹, Tao Yan¹, Lirong Chen³

CMC-Computers, Materials & Continua, Vol.79, No.3, pp. 4513-4531, 2024, DOI:10.32604/cmc.2024.051348

Abstract Addressing the challenges posed by the nonlinear and non-stationary vibrations in rotating machinery, where weak fault characteristic signals hinder accurate fault state representation, we propose a novel feature extraction method that combines the Flexible Analytic Wavelet Transform (FAWT) with Nonlinear Quantum Permutation Entropy. FAWT, leveraging fractional orders and arbitrary scaling and translation factors, exhibits superior translational invariance and adjustable fundamental oscillatory characteristics. This flexibility enables FAWT to provide well-suited wavelet shapes, effectively matching subtle fault components and avoiding performance degradation associated with fixed frequency partitioning and low-oscillation bases in detecting weak faults. In our approach,… More >

Sichen Li^1,2, Dehua Liu^1,2,*, Liang Cheng^1,2, Pan Ma^1,2

Energy Engineering, Vol.121, No.7, pp. 1921-1943, 2024, DOI:10.32604/ee.2024.049906

Abstract Due to the depletion of conventional energy reserves, there has been a global shift towards non-conventional energy sources. Shale oil and gas have emerged as key alternatives. These resources have dense and heterogeneous reservoirs, which require hydraulic fracturing to extract. This process depends on identifying optimal fracturing layers, also known as ‘sweet spots’. However, there is currently no uniform standard for locating these sweet spots. This paper presents a new model for evaluating fracturability that aims to address the current gap in the field. The model utilizes a hierarchical analysis approach and a mutation model, More > Graphic Abstract

Atsushi Fujiwara^*, Masamichi Yoshida^*, Hajime Fujimoto^†, Hiroki Nakahara^†, Kentaro Ito^‡, Kota Nishihama^§, Taro Yasuma^§, Osamu Hataji^‡, Osamu Taguchi^¶, Corina N. D’Alessandro-Gabazza^§, Esteban C. Gabazza^§, Tetsu Kobayashi^†

Oncology Research, Vol.26, No.7, pp. 1031-1036, 2018, DOI:10.3727/096504018X15151523767752

Abstract Tyrosine kinase inhibitors (TKIs) are very effective against non-small cell lung cancer (NSCLC) caused by epidermal growth factor receptor (EGFR) mutation. Before the approval of osimertinib in March 2016, there were only three available EGFR TKIs (gefitinib, erlotinib, and afatinib) for the therapy of NSCLC in Japan. Osimertinib can be indicated only against T790M⁺ lung cancer as a second-line therapy. However, whether gefitinib, erlotinib, or afatinib is most appropriate as a first-line therapy is still a controversial issue. The aim of this study was to compare the effectiveness of gefitinib, erlotinib, and afatinib. We retrospectively reviewed… More >

Yasemin Baskin^*†‡, Gizem Calibasi Kocal^‡§, Betul Bolat Kucukzeybek^¶, Mahdi Akbarpour^#, Nurcin Kayacik^**, Ozgul Sagol^††, Hulya Ellidokuz^†‡‡, Ilhan Oztop^§§

Oncology Research, Vol.24, No.1, pp. 41-53, 2016, DOI:10.3727/096504016X14576297492418

Abstract Most of the gastrointestinal stromal tumors (GISTs) have gain-of-function mutations in the KIT gene, which can be used as a prognostic marker for the biological behavior of tumors, predictive marker for the response of tyrosine kinase inhibitors, and diagnostic marker. Researchers have focused on PDGFRA mutations because of both their prognostic and predictive potential and DOG1 positivity for diagnosis on GISTs. The aim of this study is to investigate the effect DOG1, PDGFRA, and KIT mutations on the prediction of the outcome for GIST management. Polymerase chain reaction was performed for KIT gene exons 9, 11, 13,… More >

MAHER KURDI^1,*, ALAA ALKHOTANI², ABDULRAHMAN SABBAGH³, EYAD FAIZO⁴, AHMED I. LARY⁵, AHMED K. BAMAGA⁶, MAJID ALMANSOURI⁷, BADR HAFIZ⁸, THAMER ALSHARIF⁹, SALEH BAEESA⁸

Oncology Research, Vol.32, No.6, pp. 1037-1045, 2024, DOI:10.32604/or.2024.051112

Abstract Background: The dysregulation of Isocitrate dehydrogenase (IDH) and the subsequent production of 2-Hydroxyglutrate (2HG) may alter the expression of epigenetic proteins in Grade 4 astrocytoma. The interplay mechanism between IDH, O-6-methylguanine-DNA methyltransferase (MGMT)-promoter methylation, and protein methyltransferase proteins-5 (PRMT5) activity, with tumor progression has never been described. Methods: A retrospective cohort of 34 patients with G4 astrocytoma is classified into IDH-mutant and IDH-wildtype tumors. Both groups were tested for MGMT-promoter methylation and PRMT5 through methylation-specific and gene expression PCR analysis. Inter-cohort statistical significance was evaluated. Results: Both IDH-mutant WHO grade 4 astrocytomas (n = 22, 64.7%) and IDH-wildtype… More > Graphic Abstract

CHAO TANG^1,#, CHUNYU ZHONG^2,#, JUNHAO ZHU¹, FENG YUAN¹, JIN YANG¹, YONG XU^3,*, CHIYUAN MA^1,3,4,5,*

Oncology Research, Vol.32, No.6, pp. 1079-1091, 2024, DOI:10.32604/or.2024.046007

Abstract Approximately 30%–40% of growth hormone–secreting pituitary adenomas (GHPAs) harbor somatic activating mutations in GNAS (α subunit of stimulatory G protein). Mutations in GNAS are associated with clinical features of smaller and less invasive tumors. However, the role of GNAS mutations in the invasiveness of GHPAs is unclear. GNAS mutations were detected in GHPAs using a standard polymerase chain reaction (PCR) sequencing procedure. The expression of mutation-associated maternally expressed gene 3 (MEG3) was evaluated with RT-qPCR. MEG3 was manipulated in GH3 cells using a lentiviral expression system. Cell invasion ability was measured using a Transwell assay, and epithelial–mesenchymal transition… More >

Zakir Hussain Ahmed^1,*, Habibollah Haron², Abdullah Al-Tameem³

CMC-Computers, Materials & Continua, Vol.79, No.2, pp. 2399-2425, 2024, DOI:10.32604/cmc.2024.049704

Abstract Genetic algorithms (GAs) are very good metaheuristic algorithms that are suitable for solving NP-hard combinatorial optimization problems. A simple GA begins with a set of solutions represented by a population of chromosomes and then uses the idea of survival of the fittest in the selection process to select some fitter chromosomes. It uses a crossover operator to create better offspring chromosomes and thus, converges the population. Also, it uses a mutation operator to explore the unexplored areas by the crossover operator, and thus, diversifies the GA search space. A combination of crossover and mutation operators… More >

TINGTING LIU^1,#, YIWEI HAO^2,#, LIFENG ZHAO^2,*

BIOCELL, Vol.48, No.5, pp. 707-729, 2024, DOI:10.32604/biocell.2024.049130

Abstract Parkinson’s disease (PD) is a common neurodegenerative disease in the elderly, accounting for more than 1% of the population aged 65 years. Monogenic inheritance is relatively rare in PD, accounting for approximately 5% to 10% of PD patients, and there is a growing body of evidence suggesting that multiple genetic risk factors play a significant role in the pathogenesis of PD. Several groups have identified and reported a number of genes carrying mutations associated with affected family members. Mutated genes associated with PD are also candidates for idiopathic PD, and these genes may also carry… More >

Haoxue Wu^#, Xiaohan Zhang^§,#, Xiaoyu Chen, Kang Li, Aixia Xu, Zhen Huang, Jungang Dong, Chengyu Yu^*

Phyton-International Journal of Experimental Botany, Vol.93, No.3, pp. 627-640, 2024, DOI:10.32604/phyton.2024.050321

Abstract Genetic manipulation (either restraint or enhancement) of the biosynthesis pathway of α-linolenic acid (ALA) in seed oil is an important goal in Brassica napus breeding. B. napus is a tetraploid plant whose genome often harbors four and six homologous copies, respectively, of the two fatty acid desaturases FAD2 and FAD3, which control the last two steps of ALA biosynthesis during seed oil accumulation. In this study, we compared their promoters, coding sequences, and expression levels in three high-ALA inbred lines 2006L, R8Q10, and YH25005, a low-ALA line A28, a low-ALA/high-oleic-acid accession SW, and the wildtype ZS11. The expression… More >