Shuliang Xia1,2,3,#, Huikang Tao2,#, Shixin Su4, Xinxin Chen2, Li Ma2, Jianru Li5, Bei Gao6, Xumei Liu5, Lei Pi7, Jinqing Feng4, Fengxiang Li2, Jia Li4,*, Zhiwei Zhang1,3,*
Congenital Heart Disease, Vol.19, No.2, pp. 247-256, 2024, DOI:10.32604/chd.2024.052583
Abstract Aims: Multiple genes and environmental factors are known to be involved in congenital heart disease (CHD), but epigenetic variation has received little attention. Monozygotic (MZ) twins with CHD provide a unique model for exploring this phenomenon. In order to investigate the potential role of Deoxyribonucleic Acid (DNA) methylation in CHD pathogenesis, the present study examined DNA methylation variation in MZ twins discordant for CHD, especially ventricular septal defect (VSD). Methods and Results: Using genome-wide DNA methylation profiles, we identified 4004 differentially methylated regions (DMRs) in 18 MZ twin pairs discordant for CHD, and 2826 genes were… More >
Graphic Abstract
Login
Register
