CHANG SEOK LEE1, YONG JAE SHIN1, CHEOLHEE WON1, YUN-SONG LEE2, CHUNG-GYU PARK3, SANG-KYU YE1*, MYUNG-HEE CHUNG1
BIOCELL, Vol.33, No.2, pp. 107-114, 2009, DOI:10.32604/biocell.2009.33.107
Abstract Cyclooxygenase-2 (COX-2) is a key inflammatory response molecule, and associated with many immune functions of monocytes/macrophages. Particularly, interferon gamma (IFNγ)-induced COX-2 expression appears in inflammatory conditions such as viral infection and autoimmune diseases. Recently, statins have been reported to show variable effects on COX-2 expression, and on their cell and species type dependences. Based on the above description, we compared the effect of simvastatin on IFNγ-induced COX2 expression in human monocytes versus murine macrophages. In a result, we found that simvastatin suppresses IFNγ-induced COX-2 expression in human THP-1 monocytes, but rather, potentiates IFNγ-induced COX-2 expression More >
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