Eduardo Tamayo1,2,*, Ana Fernández1,2,*, Raquel Almansa2,3,*, Elena Carrasco1,2, María Heredia1,2, Carmen Lajo1,2, Lisbeth Goncalves2,3, Jose I. Gómez-Herreras1,2, Raúl Ortiz de Lejarazu2, Jesus F. Bermejo-Martin2,3,4
European Cytokine Network, Vol.22, No.2, pp. 82-87, 2011, DOI:10.1684/ecn.2011.0281
Abstract The relationships between cytokine responses in septic shock are currently poorly understood. Some
studies have pointed to a biphasic model, with an initial proinflammatory phase, followed by a reactive, antiinflammatory
response to explain the pathogenesis of the most severe form of sepsis. However, evidence for the
coexistence of both responses has been found. In this study, the plasma levels of 17 cytokines and chemokines, in 20
patients with septic shock, 11 patients with systemic inflammatory response syndrome (SIRS), during the first 24
hours following diagnosis, and 10 healthy controls, were analyzed and compared. Patients with… More >