Hai-tao Geng^*, Rui-juan Cao^*, Lei Cheng^†, Chun-yuan Liu^†

Oncology Research, Vol.25, No.7, pp. 1039-1046, 2017, DOI:10.3727/096504016X14813914187138

Abstract Hepatocyte cell adhesion molecule (hepaCAM), a new type of CAM, belongs to the immunoglobulin superfamily. Recently, hepaCAM was reported to be implicated in cancer development, and many researchers investigated its biological function in the tumorigenesis of various cancers. However, what kind of role hepaCAM plays in colorectal cancer (CRC) remains unknown. In this study, we found that hepaCAM was downregulated in CRC tissues and cell lines. Overexpression of hepaCAM inhibited CRC cell proliferation, migration, and invasion in vitro. Furthermore, the tumorigenesis assay showed that increased expression of hepaCAM suppressed CRC tumor growth and metastasis in More >

Jianping Xu, Liguo Sun, Wei Sun, Jianhai Tian, Huaiyuan Guo

Oncology Research, Vol.26, No.7, pp. 997-1003, 2018, DOI:10.3727/096504017X15140544654946

Abstract To investigate the effect of Kim-1 on 786-0 cells in vivo and in vitro, several experiments such as quantitative real-time PCR, Western blot, MTT, colony formation, and flow cytometry were performed to evaluate the biological behavior of 786-0 cells treated with Kim-1 siRNA. Furthermore, the tumor xenograft model was applied to BALB/c nude mice to assess the effect of Kim-1 silencing. Lentivirus-mediated RNAi effectively silenced Kim-1 in 786-0 cells. Kim-1 knockdown significantly inhibited the proliferation and colony formation ability of 786-0 cells (p < 0.01). The cell cycle of 786-0 cells was arrested in the G₀/G₁ phase (p < More >

Kaiyue Hong^1,2, Yasmina Radani², Waqas Ahmad², Ping Li³, Yuming Luo^1,*

Phyton-International Journal of Experimental Botany, Vol.93, No.1, pp. 45-61, 2024, DOI:10.32604/phyton.2023.046389

Abstract Carbon monoxide (CO) and nitric oxide (NO) are signal molecules that enhance plant adaptation to environmental stimuli. Auxin is an essential phytohormone for plant growth and development. CO and NO play crucial roles in modulating the plant’s response to iron deficiency. Iron deficiency leads to an increase in the activity of heme oxygenase (HO) and the subsequent generation of CO. Additionally, it alters the polar subcellular distribution of Pin-Formed 1 (PIN1) proteins, resulting in enhanced auxin transport. This alteration, in turn, leads to an increase in NO accumulation. Furthermore, iron deficiency enhances the activity of… More >

Tauqeer Ahmad Yasir^1,2, Muhammad Ateeq^1,3, Allah Wasaya^1,2,*, Mubshar Hussain², Naeem Sarwar², Khuram Mubeen⁴, Mudassir Aziz⁴, Muhammad Aamir Iqbal⁵, Chukwuma C. Ogbaga⁶, Ibrahim Al-Ashkar⁷, Md Atikur Rahman⁸, Ayman El Sabagh^9,10,*

Phyton-International Journal of Experimental Botany, Vol.92, No.11, pp. 3113-3131, 2023, DOI:10.32604/phyton.2023.029502

Abstract Drought is one of the critical limitations to agricultural soils and crop plants. Scarcity of water is increasing due to climate change that lead to increasing threats to global food security. Therefore, ecofriendly and cost effective strategies are highly desirable for mitigating drought stress along with sustainable and smart agricultural production. The aim of the study was to mitigate DS using seed priming and exogenous supplementation of β-aminobutyric acid (BABA) in linseed (Linum usitatissimum L.). Different doses (0, 50, 100 and 150 µM) of BABA were used for seed priming agent and foliar spraying under three… More >

KAMILA CZUBAK-PROWIZOR^*, MARIA SWIATKOWSKA

BIOCELL, Vol.47, No.4, pp. 731-737, 2023, DOI:10.32604/biocell.2023.025677

Abstract Junctional adhesion molecule-A (JAM-A), also known as the F11 receptor (F11R), is one of the tight junction components. JAM-A is a transmembrane glycoprotein that regulates many cellular processes, i.e., angiogenesis, leukocyte transendothelial migration, intercellular permeability, epithelial-to-mesenchymal transition, and platelet activation. Of note, it is involved in the pathogenesis of various cancer types, including gynecological cancers. Only a few studies are available about this cancer type. Observed aberrant JAM-A expression in gynecological cancers correlates with poor patient prognosis. To the best of our knowledge, conflicting JAM-A roles in various cancer types suggest that its involvement is More >

Xuyang Yao^1,*, Kecheng Liu¹, Zenan Zhou¹, Jun Zhou¹, Xianbin Huang², Tiemei Lu¹, Yongsheng Yu¹, He Li²

FDMP-Fluid Dynamics & Materials Processing, Vol.19, No.7, pp. 1775-1787, 2023, DOI:10.32604/fdmp.2023.025843

Abstract Water-based drilling fluids can cause hydration of the wellbore rocks, thereby leading to instability. This study aimed to synthesize a hydrophobic small-molecule polymer (HLMP) as an inhibitor to suppress mud shale hydration. An infrared spectral method and a thermogravimetric technique were used to characterize the chemical composition of the HLMP and evaluate its heat stability. Experiments were conducted to measure the linear swelling, rolling recovery rate, and bentonite inhibition rate and evaluate accordingly the inhibition performance of the HLMP. Moreover, the HLMP was characterized through measurements of the zeta potential, particle size distribution, contact angles,… More > Graphic Abstract

Baohua Zhao¹, Teng Zhang^2,*, Wenwen Liu², Fansong Meng², Chengben Liu¹, Nuo Chen², Zhi Li³, Zhaobin Liu³, Xiyou Li^2,*

Journal of Renewable Materials, Vol.11, No.4, pp. 1533-1554, 2023, DOI:10.32604/jrm.2022.023192

Abstract

Due to the solution processable nature, the prepared perovskite films are polycrystalline with considerable number of defects. These defects, especially defects at interface accelerate the carrier recombination and reduce the carrier collection. Besides, the surface defects also affect the long-term stability of the perovskite solar cells (PVSCs). To solve this problem, surface passivation molecules are introduced at selective interface (the interface between perovskite and carrier selective layer). This review summarizes recent progress of small molecules used in PVSCs. Firstly, different types of defect states in perovskite films are introduced and their effects on device performance are

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Yangyang Hao, Yue Liu^*, Guorui Cao^*

Journal of Renewable Materials, Vol.10, No.12, pp. 3505-3519, 2022, DOI:10.32604/jrm.2022.023122

Abstract Aiming to reduce the defects of perovskite film and improve carrier transport, an organic small molecule, benzo [d]isothiazol-3(2H)-one 1,1-dioxide (OBS), is introduced as an additive in the solution-processing of perovskite and prepare uniform perovskite films with a continuous distribution of OBS at grain boundaries. Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy are conducted to reveal the interactions of hydrogen bonding and coordination bonding between OBS and perovskite. Various characterizations (including X-ray diffraction, UV-vis spectroscopy, electrochemical impedance spectroscopy, etc.) are conducted to uncover the effect of OBS on device performance. Consequently, high efficiency of 23.26% More > Graphic Abstract

Minxi Rong¹, Yong Li^1,*, Xiaoli Guo^1,*, Tao Zong², Zhiyuan Ma², Penglei Li²

Oncologie, Vol.24, No.2, pp. 309-327, 2022, DOI:10.32604/oncologie.2022.021256

Abstract Objectives: The ERα biological activity prediction model is constructed by the compound molecular data of the anti-breast cancer therapeutic target ERα and its biological activity data, which improves the screening efficiency of anti-breast cancer drug candidates and saves the time and cost of drug development. Methods: In this paper, Ridge model is used to screen out molecular descriptors with a high degree of influence on the biological activity of Erα and divide datasets with different numbers of the molecular descriptors by screening results. Random Forest (RF) is trained by Root Mean Square Error (RMSE) and Coefficient of… More >

Prasanna Rajagopalan^*†, Abdulrahim Hakami^*†, Mohammed Ragab^*, Ashraf Elbessoumy^*‡

Oncology Research, Vol.27, No.8, pp. 957-964, 2019, DOI:10.3727/096504019X15555428221646

Abstract Arylidene analogs are well proven for biological activities. FCY-302, a novel small molecule belonging to this class, was screened for its biological efficacy in leukemia and myeloma cells. FCY-302 selectively inhibited proliferation of cancer cells with GI50 values of 395.2 nM, 514.6 Nm, and 642.4 nM in HL-60, Jurkat, and RPMI-8226 cells, respectively. The compound also increased sub-G0 peak in the cancer cell cycle and favored apoptosis determined by annexin V assay. The compound decreased the antiapoptotic Bcl-2 levels and increased proapoptotic Bax proteins in leukemia and myeloma cell lines. FCY-302 attenuated the mitochondrial membrane-bound Na⁺ More >