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  • Open Access

    ARTICLE

    Silencing of ATP4B of ATPase H+/K+ Transporting Beta Subunit by Intragenic Epigenetic Alteration in Human Gastric Cancer Cells

    Shuye Lin*†, Bonan Lin*, Xiaoyue Wang*, Yuanming Pan, Qing Xu*, Jin-Shen He*, Wanghua Gong§, Rui Xing, Yuqi He, Lihua Guo*, Youyong Lu, Ji Ming Wang, Jiaqiang Huang*†

    Oncology Research, Vol.25, No.3, pp. 317-329, 2017, DOI:10.3727/096504016X14734735156265

    Abstract The ATPase H+/K+ Transporting Beta Subunit (ATP4B) encodes the b subunit of the gastric H+, K+ -ATPase, which controls gastric acid secretion and is therefore a target for acid reduction. Downregulation of ATP4B was recently observed in human gastric cancer (GC) without known mechanisms. In the present study, we demonstrated that ATP4B expression was decreased in human GC tissues and cell lines associated with DNA hypermethylation and histone hypoacetylation of histone H3 lysine 9 at its intragenic region close to the transcriptional start site. The expression of ATP4B was restored in GC cell lines by treatment with… More >

  • Open Access

    ARTICLE

    Multiple Perspective of Multipredictor Mechanism and Multihistogram Modification for High-Fidelity Reversible Data Hiding

    Kai Gao1, Chin-Chen Chang1,*, Chia-Chen Lin2,*

    Computer Systems Science and Engineering, Vol.48, No.3, pp. 813-833, 2024, DOI:10.32604/csse.2024.038308

    Abstract Reversible data hiding is a confidential communication technique that takes advantage of image file characteristics, which allows us to hide sensitive data in image files. In this paper, we propose a novel high-fidelity reversible data hiding scheme. Based on the advantage of the multipredictor mechanism, we combine two effective prediction schemes to improve prediction accuracy. In addition, the multihistogram technique is utilized to further improve the image quality of the stego image. Moreover, a model of the grouped knapsack problem is used to speed up the search for the suitable embedding bin in each sub-histogram. More >

  • Open Access

    ARTICLE

    DNA Methylation Variation Is Identified in Monozygotic Twins Discordant for Congenital Heart Diseases

    Shuliang Xia1,2,3,#, Huikang Tao2,#, Shixin Su4, Xinxin Chen2, Li Ma2, Jianru Li5, Bei Gao6, Xumei Liu5, Lei Pi7, Jinqing Feng4, Fengxiang Li2, Jia Li4,*, Zhiwei Zhang1,3,*

    Congenital Heart Disease, Vol.19, No.2, pp. 247-256, 2024, DOI:10.32604/chd.2024.052583

    Abstract Aims: Multiple genes and environmental factors are known to be involved in congenital heart disease (CHD), but epigenetic variation has received little attention. Monozygotic (MZ) twins with CHD provide a unique model for exploring this phenomenon. In order to investigate the potential role of Deoxyribonucleic Acid (DNA) methylation in CHD pathogenesis, the present study examined DNA methylation variation in MZ twins discordant for CHD, especially ventricular septal defect (VSD). Methods and Results: Using genome-wide DNA methylation profiles, we identified 4004 differentially methylated regions (DMRs) in 18 MZ twin pairs discordant for CHD, and 2826 genes were… More > Graphic Abstract

    DNA Methylation Variation Is Identified in Monozygotic Twins Discordant for Congenital Heart Diseases

  • Open Access

    ARTICLE

    Circ_0053943 complexed with IGF2BP3 drives uveal melanoma progression via regulating N6-methyladenosine modification of Epidermal growth factor receptor

    ANDI ZHAO1,2,#, YUE WANG3,#, ZIJIN WANG1,2, QING SHAO1,2, QI GONG1,2, HUI ZHU1,2, SHIYA SHEN1,2, HU LIU1,2,*, XUEJUAN CHEN1,2,*

    Oncology Research, Vol.32, No.5, pp. 983-998, 2024, DOI:10.32604/or.2024.045972

    Abstract Numerous studies have characterized the critical role of circular RNAs (circRNAs) as regulatory factors in the progression of multiple cancers. However, the biological functions of circRNAs and their underlying molecular mechanisms in the progression of uveal melanoma (UM) remain enigmatic. In this study, we identified a novel circRNA, circ_0053943, through re-analysis of UM microarray data and quantitative RT-PCR. Circ_0053943 was found to be upregulated in UM and to promote the proliferation and metastatic ability of UM cells in both in vitro and in vivo settings. Mechanistically, circ_0053943 was observed to bind to the KH1 and KH2 domains of insulin-like… More > Graphic Abstract

    <i>Circ_0053943</i> complexed with IGF2BP3 drives uveal melanoma progression via regulating N6-methyladenosine modification of <i>Epidermal growth factor receptor</i>

  • Open Access

    ARTICLE

    Chitosan Modification by New Chromophore 4-(3-(4- nitrophenyl) thioureido) benzoic acid: Synthesis, Characterization and Evaluation

    KAZIM SHAMIM RIZVI, P. K. DUTTA

    Journal of Polymer Materials, Vol.36, No.3, pp. 217-228, 2019, DOI:10.32381/JPM.2019.36.03.2

    Abstract In this investigation we have shown the preparation of carboxylic acid containing new chromophore : 4-(3-(4-nitrophenyl) thioureido) benzoic acid and its use.The chemical modification of chitosan, e.g., chitosan- acid salt complexes is done under mild conditions. The synthesis of chromophore was carried out by conventional methods and the novel polymer complex was soluble in most of the organic solvents. The modified chitosan was analyzed by various techniques like optical properties by UV and SHG spectroscopy which showed red shift. The antibacterial activity showed obvious effect against food pathogenic bacteria. More >

  • Open Access

    ARTICLE

    Influence of Poly (vinyl butyral) Modification on the Mechanical and Thermal Properties of Kevlar Fiber Reinforced Novolac epoxy/multiwalled carbon nanotube nanocomposites

    KAVITA*, R.K. TIWARI

    Journal of Polymer Materials, Vol.36, No.2, pp. 195-205, 2019, DOI:10.32381/JPM.2019.36.02.7

    Abstract The effect of poly (vinyl butyral) and acid functionalized multiwalled carbon nanotubes (f-MWCNT) on the thermal and mechanical performance of Kevlar fiber reinforced novolac epoxy nanocomposites was investigated and presented in this paper. Nanocomposite containing 1.5 wt. % poly (vinyl butyral) and 0.5 wt. % f-MWCNT exhibited best thermal and mechanical properties (except flexural strength) among all the nanocomposites reported here. It showed ~5%, 27% and 126 % improvement in tensile strength, young’s modulus and impact strength respectively as compared to the neat novolac epoxy Kevlar composite.Nanocomposite containing 0.5 wt. % f- MWCNT and 2 More >

  • Open Access

    ARTICLE

    Robust Color Fastness of Dyed Silk Fibroin Film By Coupling Modification Dyeing with Aniline Diazonium Salt

    ZONGQIAN WANG, HAIWEI YANG, JIAN XING, ZHI LIU*

    Journal of Polymer Materials, Vol.36, No.2, pp. 149-159, 2019, DOI:10.32381/JPM.2019.36.02.4

    Abstract Colored silk fibroin (SF) film can change the proportion of transmitted light composition and therefore shows potential application in optoelectronics area. However, few methods are reported for the preparation of colored SF film with good color fastness. Herein, colored SF film was prepared by coupling modification dyeing (CM-dyeing) of SF tyrosine residues in solution. SF film shows excellent color fastness due to the formation of the azo covalent bond formed by electrophilic substitution reaction between SF tyrosine residues and aniline diazonium salt. Furthermore, compared with the undyed film, the dyed SF film is effectively preserved More >

  • Open Access

    ARTICLE

    Synthesis and Characterization of New Chromophore 4-2-(2-hydroxy-5-(4 nitrophenyl) diazenyl) benzylidene) hydrazinyl) Benzoic Acid and its use in Chitosan Modification

    KAZIM SHAMIM RIZVI, P.K.DUTTA*

    Journal of Polymer Materials, Vol.36, No.1, pp. 75-85, 2019, DOI:10.32381/JPM.2019.36.01.6

    Abstract The present investigation deals with the preparation of carboxylic acid containing new chromophore : 4-2-(2-hydroxy-5-(4-nitrophenyl) diazenyl) benzylidene) hydrazinyl) benzoic acid and its use for chemical modification of chitosan, e.g., chitosan-acid salt complexes under mild conditions. Optical properties of chitosan acid complexes were evaluated by UV and SHG spectroscopy which showed red shift. Antibacterial activity of prepared chitosan acid complexes showed obvious effect against food pathogenic bacteria. The novel polymer complex was soluble in most of the organic solvents. More >

  • Open Access

    ARTICLE

    Synthesis and Characterization of poly (N-glycidyl-2- oxazolidone) Using a Green and Efficient Catalyst

    SORAYA SEGHIER1,2,*, MOHAMMED BELBACHIR1

    Journal of Polymer Materials, Vol.38, No.3-4, pp. 205-218, 2021, DOI:10.32381/JPM.2021.38.3-4.3

    Abstract In the present paper, we report the synthesis of a new amino polymer made of oxazolidinone using an efficient ecocatalyst called Maghnite-H+. The synthesis process contains two steps: the first consists to the preparation of an amino oxiran 3-(oxiran-ylmethyl) oxazolidin- 2-one (OMO) by a substitution reaction of epichlorhydrin by 2-oxazolidinone, the second step concerns a green polymerization of the resultant oxiran by a ring opening reaction catalysed by Maghnite-H+. The polymer have been successfully prepared and characterized by various techniques, such as 1H NMR, 13C NMR, IR, which were used to elucidate the structural characteristics of the More >

  • Open Access

    REVIEW

    A Brief Review of Surface Modification of Carbonyl Iron Powders (CIPs) for Magnetorheological Fluid Applications

    THIRUMALAISAMY SURYAPRABHAA, CHUNGHYUN CHOIA, ZUBAIR AHMED CHANDIOB, LAWRENCE ROBERT MSALILWAB, TAEGWANG YUNC,*, JUN YOUNG CHEONGB,*, BYUNGIL HWANGA,*

    Journal of Polymer Materials, Vol.40, No.3-4, pp. 191-204, 2023, DOI:10.32381/JPM.2023.40.3-4.5

    Abstract Magnetorheological fluids (MRFs) is a smart fluid system that exhibits swift and reversible alterations in their rheological characteristics when exposed to an external magnetic field. MRFs are used for applications in various areas, including automotive systems, robotics, aerospace, and civil engineering. The performance of MRFs depends on the behavior of the dispersed magnetic particles, necessitating thoughtful consideration of particle traits to optimize fluid performance. Carbonyl Iron Powders (CIPs), high purity iron (>98%) reduced from penta carbonyl iron, are widely employed in MRFs due to their exceptional magnetic characteristics. Nevertheless, the innate surfaces of CIPs tend… More >

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