Zhanwu Hou¹, Linfeng Xu^2,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.1, pp. 1-0, 2024, DOI:10.32604/icces.2024.012892

Abstract The cell-cell interaction between immune cells and tumor cells in the tumor microenvironment plays an important role in the genesis and development of tumors. However, due to the lack of methods to systematically identify the interaction between the two, the specific molecular mechanisms involved are not well understood. The microfluidic platform provides a high-throughput and precise method for studying cell interactions in microreactive systems. However, the traditional platform for studying cell interactions is the closed droplet system, which is easy to cause the consumption of nutrients and the accumulation of wastes, thus interfering with cell… More >

Ying Mao¹, Chaojing Li¹, Peng Ge¹, Fujun Wang^1,*, Lu Wang^1,*

Molecular & Cellular Biomechanics, Vol.15, No.3, pp. 143-154, 2018, DOI:10.3970/mcb.2018.03987

Abstract Heparin/ PEG-PCL core-shell microcarriers were fabricated in one-step via coaxial-electrospraying technology. Optimization of the coaxial-electrospraying processing is by controlling the PEG-PCL concentration, applied voltage, receiving distance, and feed rate. The influence of the electrospray parameters on microsphere morphology was studied by optical microscopy and scanning electron microscopy. The functional groups and components of the electrosprayed microspheres were characterized by Fourier transform infrared spectroscopy (FTIR). Transmission electron microscope (TEM) observation proved the core-shell structure of heparin-loaded PEG-PCL microspheres. Drug loading and releasing study demonstrated that PEG-PCL concentration could control the encapsulation efficiency and releasing activity of More >