Yunduo Charles Zhao1,2,#, Parham Vatankhah1,#, Tiffany Goh1,2,3, Jiaqiu Wang4, Xuanyi Valeria Chen1, Moein Navvab Kashani5,6, Keke Zheng7, Zhiyong Li4, Lining Arnold Ju1,2,3,*
Molecular & Cellular Biomechanics, Vol.18, No.1, pp. 1-10, 2021, DOI:10.32604/mcb.2021.012598
- 26 January 2021
Abstract Platelet aggregation plays a central role in pathological thrombosis, preventing healthy physiological blood flow within the circulatory system. For decades, it was believed that platelet aggregation was primarily driven by soluble agonists such as thrombin, adenosine diphosphate and thromboxane A2. However, recent experimental findings have unveiled an intriguing but complementary biomechanical mechanism—the shear rate gradients generated from flow disturbance occurring at sites of blood vessel narrowing, otherwise known as stenosis, may rapidly trigger platelet recruitment and subsequent aggregation. In our Nature Materials 2019 paper [1], we employed microfluidic devices which incorporated micro-scale stenoses to elucidate the… More >