Nikhil Gadewal*1, Rohit Kumar†1, Swapnil Aher†, Anagha Gardane†, Tarang Gaur†, Ashok K. Varma*‡§, Navin Khattry¶, Syed K. Hasan†§¶
Oncology Research, Vol.28, No.3, pp. 321-330, 2020, DOI:10.3727/096504020X15816752427321
Abstract Acute myeloid leukemia (AML) with NPM1 mutation is a disease driving genetic alteration with good prognosis. Although it has been suggested that NPM1 mutation induces chemosensitivity in leukemic cells, the
underlying cause for the better survival of NPM1 mutated patients is still not clear. Mutant NPM1 AML has
a unique microRNA and their target gene (mRNA) signature compared to wild-type NPM1. Dynamic regulation of miRNA–mRNA has been reported to influence the prognostic outcome. In the present study, in silico
expression data of miRNA and mRNA in AML patients was retrieved from genome data commons, and differentially expressed miRNA and mRNA… More >
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