Zhong Yu, Xu Zai-Chun, Han Wun-Lun, Zhu Yun-Yun
Oncology Research, Vol.23, No.4, pp. 147-154, 2015, DOI:10.3727/096504016X14519157902645
Abstract Bone morphogenetic protein-7 (BMP-7) inhibited the pathogenesis of renal injury in response to a variety of
stimuli. However, little is known about the molecular regulation and mechanism of endogenous BMP-7 and
its renoprotective functions. This study examined the regulation of BMP-7 and its role in the fibronectin secretion and apoptosis of NRK-52E cells resulting from transforming growth factor-β1 (TGF-β1) in vitro. Results
showed that TGF-β1 promoted factor-associated suicide (FAS), FAS ligand (FASL), fibronectin (FN), and
miRNA-21 expression, while it downregulated phospho-Smad1 (pSmad1), pSmad5, and pSmad8 expressions
in NRK-52E cells. In contrast, BMP-7 alleviated TGF-β1-induced cell More >
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