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  • Open Access

    ARTICLE

    The correlation of miRNA expression and tumor mutational burden in uterine corpus endometrial carcinoma

    YANYA CHEN1,#, HONGYUAN WU2,#, RUISI ZHOU5,#, HELING DONG4, XUEFANG ZHANG2, XUEWEI WU1, WENSHAN CHEN1, YANTING YOU5,*, YIFEN WU3,*

    BIOCELL, Vol.47, No.6, pp. 1353-1364, 2023, DOI:10.32604/biocell.2023.027346

    Abstract Background: The relationship between microRNA (miRNA) expression patterns and tumor mutation burden (TMB) in uterine corpus endometrial carcinoma (UCEC) was investigated in this study. Methods: The UCEC dataset from The Cancer Genome Atlas (TCGA) database was used to identify the miRNAs that differ in expression between high TMB and low TMB sample sets. The total sample sets were divided into a training set and a test set. TMB levels were predicted using miRNA-based signature classifiers developed by Lasso Cox regression. Test sets were used to validate the classifier. This study investigated the relationship between a miRNA-based signature… More >

  • Open Access

    ARTICLE

    Integrated Transcriptome and Small RNA Sequencing Analyses Reveals Insights into the Molecular Mechanism of Seed Germination in Mung Bean

    Yanyan Pu1,#, Liwen Wang2,#, Leilei Li3, Yujun Si4, Shubin Xie2, Yunzhe Cong1, Dong Wang1, Yongchao Gong1, Rumei Tian1, Xue Chen3, Xiaoyan Zhang1, Min Liu1, Hanfeng Ding1,3,*, Nana Li1,3,*

    Phyton-International Journal of Experimental Botany, Vol.92, No.6, pp. 1793-1812, 2023, DOI:10.32604/phyton.2023.026822

    Abstract During the life cycle of a plant, seed germination is crucial. Upon ingestion of water, the dry seeds resumed energy metabolism and cellular repair. To dissect the complex mechanisms at the very beginning of seed germination, two approaches including transcriptome and small RNA sequencing were conducted during the water imbibition process of mung bean seeds compared with dry seed. The transcriptome sequencing analysis identified 10,108 differentially expressed genes (DEGs) between dry and imbibed mung bean seeds. KEGG enrichment analyses demonstrated numerous DEGs involved in hormone signaling pathways, carbohydrate, and energy metabolism. Out of the total… More >

  • Open Access

    ARTICLE

    Study on the Value of Ultrasound Elastography Combined with Plasma miRNA Expression in the Early Detection of Breast Cancer

    Qian Zhang1,2,#, Yuanyuan Cao2,#, Mingming Fang3, Qin Yang2, Pingyang Zhang1,*

    Oncologie, Vol.24, No.4, pp. 717-727, 2022, DOI:10.32604/oncologie.2022.026998

    Abstract Background: Breast cancer (BC) is the most common malignant tumor in women, and its morbidity and mortality are increasing each year, due to the lack of specific clinical symptoms in the early stage of BC, and the lack of diagnostic methods for early breast cancer. Therefore, identifying an effective diagnostic method for early BC has become urgent. Materials and Methods: Breast lesions with a histological diagnosis that were examined by ultrasonic elastography (UE) in our department from June 2020 to December 2021 were reviewed. qRT-PCR was performed to measure the expression levels of miR-144-5p and miR-26b-5p in… More >

  • Open Access

    ARTICLE

    BET protein inhibitor apabetalone represses Porphyromonas gingivalis LPS-induced macrophage M1 polarization via regulating miR-130a/STAT3 axis

    MEIHUA CHEN1,2, HUIHUI WANG3, XIAOFENG CHEN1,2, YAN CHEN1,2, TIANYING BIAN1,2,*

    BIOCELL, Vol.46, No.10, pp. 2281-2289, 2022, DOI:10.32604/biocell.2022.020697

    Abstract Periodontitis is a frequent chronic inflammatory disorder destroying periodontium. Recent studies have revealed the role of bromodomain and extraterminal domain inhibitor (BETi) and microRNA (miR)-130a in regulating macrophage polarization and pro-inflammatory response. However, little is known about whether apabetalone (a novel BETi) and miR-130a are correlated with chronic inflammatory state in periodontitis by regulating macrophage polarization. Here murine RAW264.7 macrophages were applied as an in vitro inflammatory model. After treatment with Porphyromonas gingivalis-derived lipopolysaccharide (Pg LPS) and apabetalone, the expression of macrophage M1 polarization markers and inflammatory cytokines was assessed using real-time PCR, western blot, and enzyme-linked… More >

  • Open Access

    ARTICLE

    MDA-TOEPGA: A novel method to identify miRNA-disease association based on two-objective evolutionary programming genetic algorithm

    BUWEN CAO1,*, JIAWEI LUO2,*, SAINAN XIAO1,2, XIANGJUN ZHOU1

    BIOCELL, Vol.46, No.8, pp. 1925-1933, 2022, DOI:10.32604/biocell.2022.019613

    Abstract The association between miRNA and disease has attracted more and more attention. Until now, existing methods for identifying miRNA related disease mainly rely on top-ranked association model, which may not provide a full landscape of association between miRNA and disease. Hence there is strong need of new computational method to identify the associations from miRNA group view. In this paper, we proposed a framework, MDA-TOEPGA, to identify miRNAdisease association based on two-objective evolutionary programming genetic algorithm, which identifies latent miRNAdisease associations from the view of functional module. To understand the miRNA functional module in diseases, More >

  • Open Access

    ARTICLE

    miRNA-148b-3p targeting SOCS3 inhibits macrophage M2 polarization by JAK2/STAT3 pathway in immune thrombocytopenia

    YANG YANG, LIJUAN FU, CHUNMEI CHEN, MEIWEI HU

    BIOCELL, Vol.46, No.5, pp. 1319-1328, 2022, DOI:10.32604/biocell.2022.015760

    Abstract Aberrant expression of miRNAs is significantly correlated with the occurrence of immune thrombocytopenic purpura (ITP). The immune imbalance of M1/M2 macrophage contributes to the development of ITP. However, the role of miR-148b-3p in macrophage phenotype imbalance remains unknown in ITP. In this study, we aimed to explore whether miR-148b-3p inhibits M2 macrophage polarization in ITP and to investigate the underlying mechanism. Peripheral blood from 22 ITP patients were collected, and real-time PCR confirmed that miR-148b-3p was up-regulated and Western blot analyses detected the expression of SOCS3 was down-regulated. Subsequent dual-luciferase reporter gene assay indicated that More >

  • Open Access

    ARTICLE

    Phylogenetic analysis and target gene prediction of miR477 gene family in grape

    HUI-YING JIN1,2, MAO-SONG PEI1,2, DA-LONG GUO1,2,*

    BIOCELL, Vol.46, No.4, pp. 941-949, 2022, DOI:10.32604/biocell.2022.016718

    Abstract To understand the molecular characteristics of the miR477 gene family of grape (Vvi-miR477) and to predict its target genes, the Vvi-miR477 genes were identified from previous small RNA sequencing data, then phylogenetic analysis and prediction of target gene were conducted. The Vvi-miR477 family consists of two precursor sequences and three mature sequences. The miR477 family members were mostly 19-22nt in length. The sequence is relatively conservative. Vvi-MIR477a and Vvi-MIR477b are located on chromosomes 1 and 2, respectively. These precursor sequences can form the typical stable stem-loop structure. Their minimum folding free energy is −39.10 kcal/mol and −50.90 kcal/mol, More >

  • Open Access

    ARTICLE

    INTS-MFS: A novel method to predict microRNA-disease associations by integrating network topology similarity and microRNA function similarity

    BUWEN CAO1,*, JIAWEI LUO2,*, SAINAN XIAO1, KAI ZHAO1, SHULING YANG1

    BIOCELL, Vol.46, No.3, pp. 837-845, 2022, DOI:10.32604/biocell.2022.017538

    Abstract Identifying associations between microRNAs (miRNAs) and diseases is very important to understand the occurrence and development of human diseases. However, these existing methods suffer from the following limitation: first, some disease-related miRNAs are obtained from the miRNA functional similarity networks consisting of heterogeneous data sources, i.e., disease similarity, protein interaction network, gene expression. Second, little approaches infer disease-related miRNAs depending on the network topological features without the functional similarity of miRNAs. In this paper, we develop a novel model of Integrating Network Topology Similarity and MicroRNA Function Similarity (INTS-MFS). The integrated miRNA similarities are calculated… More >

  • Open Access

    ARTICLE

    Uncoupling tumor necrosis factor-α and interleukin-10 at tumor immune microenvironment of breast cancer through miR-17-5p/MALAT-1/H19 circuit

    RAGHDA A. SOLIMAN1, RANA A. YOUNESS1,2,*, TAMER M. MANIE3, EMAD KHALLAF4, MOHAMED EL-SHAZLY1, MONA ABDELMOHSEN5, HEBA HANDOUSSA1, MOHAMED Z. GAD6,*

    BIOCELL, Vol.46, No.3, pp. 769-783, 2022, DOI:10.32604/biocell.2022.016636

    Abstract Triple Negative Breast Cancer (TNBC) immunotherapy has recently shown promising approach. However, some TNBC patients presented with resistance. One of the reasons was attributed to the excessive release of cytokines at the tumor microenvironment (TME) such as Tumor necrosis factor alpha (TNF-α) and Interleukin-10 (IL-10). Fine regulation of these cytokines’ levels via non-coding RNAs (ncRNAs) might alleviate the immune quiescent nature of TME at TNBC tumors. However, the extrapolation of ncRNAs as therapeutic tools is highly challenging. Therefore, disentanglement the nature for the isolation of natural compounds that could modulate the ncRNAs and their respective… More >

  • Open Access

    REVIEW

    Understanding the role of miRNAs in the pathogenesis of brain arteriovenous malformations

    ILGIZ GAREEV1, OZAL BEYLERLI1, CHUNLEI WANG2,3, ANDREI SOKHATSKII2,3, YANCHAO LIANG2,3, HUAN XIANG2,3, CHUNYANG LIU2,3, XUN XU2,3, YANG GUANG2,3

    BIOCELL, Vol.46, No.1, pp. 27-35, 2022, DOI:10.32604/biocell.2022.016288

    Abstract Brain arteriovenous malformations (AVMs) are abnormal vessels that are prone to rupture, causing life-threatening intracerebral hemorrhage (ICH). Understanding the molecular basis of pathogenesis, timely diagnosis, and treatment of brain AVMs are some of the urgent problems in neurosurgery. MicroRNAs (miRNAs) are small endogenous RNAs that regulate gene-expression posttranscriptionally. MiRNAs are involved in almost all biological processes, including cell proliferation, apoptosis, and cell differentiation. Recent studies have shown that miRNAs can be involved in brain AVMs formation and rupture. There are also extracellular forms of miRNAs. Circulating miRNAs have been detected in the blood circulation and More >

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