Ting La*†, Lei Jin*‡, Xiao Ying Liu*, Ze Hua Song*, Margaret Farrelly†, Yu Chen Feng†, Xu Guang Yan†, Yuan Yuan Zhang*,† Rick F. Thorne*,*§ Xu Dong Zhang*†, Liu Teng*
Oncology Research, Vol.28, No.4, pp. 385-398, 2020, DOI:10.3727/096504020X15861709922491
Abstract The deubiquitinase cylindromatosis (CYLD) functions as a tumor suppressor inhibiting cell proliferation in
many cancer types including melanoma. Here we present evidence that a proportion of melanoma cells are
nonetheless addicted to CYLD for survival. The expression levels of CYLD varied widely in melanoma cell
lines and melanomas in vivo, with a subset of melanoma cell lines and melanomas displaying even higher
levels of CYLD than melanocyte lines and nevi, respectively. Strikingly, although short hairpin RNA (shRNA)
knockdown of CYLD promoted, as anticipated, cell proliferation in some melanoma cell lines, it reduced
cell viability in a fraction of melanoma cell… More >
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