Fei Ji1, Delinaer Wuerkenbieke1, Yan He, Yan Ding, Rong Du
Oncology Research, Vol.26, No.3, pp. 353-361, 2018, DOI:10.3727/096504017X15002869385155
Abstract Increasing evidence has indicated that long noncoding RNAs (lncRNAs) are a class of significant regulators in various tumorigenesis processes. The lncRNA homeobox transcript antisense RNA (HOTAIR) has
been reported to act as a functional lncRNA in cervical cancer development. The present study investigated
the underlying mechanism of HOTAIR and miR-17-5p in cervical cancer tumorigenesis. The results showed
that HOTAIR expression was significantly upregulated in both cervical cancer tissues and cell lines. Lossof-function experiments showed that HOTAIR knockdown inhibited the proliferation, migration, and invasion of cervical cells. In addition, miR-17-5p expression was downregulated in cervical cancer More >
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