Liang Wu, Yuefeng Li, Jingye Li, Deliang Ma
Oncology Research, Vol.27, No.4, pp. 459-467, 2019, DOI:10.3727/096504018X15193500663936
Abstract A large number of microRNAs (miRNAs) have been previously demonstrated to be dysregulated in breast
cancer (BC), and alterations in miRNA expression may affect the initiation and progression of BC. This
study showed that miR-664 expression was obviously reduced in BC tissues and cell lines. Resumption
of the expression of miR-664 attenuated the proliferation and invasion of BC cells. The molecular mechanisms underlying the inhibitory effects of BC cell proliferation and invasion by miR-664 were also studied.
Insulin receptor substrate 1 (IRS1) was identified as a novel and direct target of miR-664. In addition, siRNAmediated More >
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