Jiangtao Liu*, Yanli Jia*, Lijuan Jia*, Tingting Li†, Lei Yang‡, Gongwen Zhang‡
Oncology Research, Vol.27, No.2, pp. 269-279, 2019, DOI:10.3727/096504018X15215019227688
Abstract MicroRNAs are essential regulators of cancer-associated genes at the posttranscriptional level, and their
expression is altered in cancer tissues. Herein we sought to identify the regulation of miR-615-3p in NSCLC
progression and its mechanism. miR-615-3p expression was significantly downregulated in NSCLC tissue
compared to control normal tissue. Exogenous overexpression of miR-615-3p inhibited the growth and metastasis of NSCLC cells. In addition, the in vivo mouse xenograft model showed that overexpression of miR-
615-3p inhibited NSCLC growth and lung metastasis, whereas decreased expression of miR-615-3p caused an
opposite outcome. Furthermore, we revealed that insulin-like growth factor More >
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