Jin Wang*, Wenquan Pang*, Zhenbai Zuo*, Wenyan Zhang*, Weidong He†
Oncology Research, Vol.25, No.8, pp. 1297-1304, 2017, DOI:10.3727/096504017X14873430389189
Abstract Spinal osteosarcoma (OS) is a malignant tumor that has a poor outcome. MicroRNA-520b (miR-520b) acts as
a cancer suppressor in various types of cancer. Because of the limited amount of literature on OS, we aimed to
identify the role of miR-520b in OS. The miR-520b level in clinical spinal OS tissues and adjacent nontumor
tissues as well as in cell lines was assessed. The effect of miR-520b on cell proliferation, migration, invasion,
and frizzled-8 (FZD8) degradation were all evaluated. Alterations of key proteins involved in the Wnt/b-catenin
pathway were assessed by Western blot analysis. In… More >
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