Hongyan Ge*, Di Zou†, Yingshu Wang*, Hao Jiang*, Liping Wang‡
Oncology Research, Vol.25, No.1, pp. 29-34, 2017, DOI:10.3727/096504016X14719078133168
Abstract Aberrantly expressed microRNAs (miRNAs/miRs) and their role in cancer development have recently gained
more attention. However, the potential role of miRNAs in hepatocellular carcinoma (HCC) remains largely
unknown. In this study, we demonstrated that miR-377 was markedly downregulated in HCC cell lines and
primary human HCC tissues. The decreased expression of miR-377 contributes to the upregulation of Bcl-xL
expression by targeting its 3'-untranslated region (3'-UTR). Functionally, knockdown of miR-377 noticeably
increased HCC cell growth and colony formation and inhibited apoptosis. In contrast, overexpression of miR-377
suppressed cell proliferation and increased apoptosis. This study provides new More >
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