Daofu Jia*, Yanping Niu†, Dongling Li‡, Zhaorui Liu§
Oncology Research, Vol.26, No.5, pp. 753-764, 2018, DOI:10.3727/096504017X15024946480113
Abstract Osteosarcoma is a highly aggressive malignant bone tumor with poor prognosis. Evidence has suggested that
lncRNAs are deregulated in multiple cancers. In this study, we investigated the role of the lncRNA C2dat1 on
the biological functions of osteosarcoma cells. The expressions of C2dat1, miR-34a-5p, and Sirt1 in human
osteosarcoma cells were altered by transfection with their specific vectors/shRNA or mimic/inhibitor. Cell
viability, migration, invasion, and apoptosis were assessed posttransfection. The mRNA and protein levels of
C2dat1, miR-34a-5p, and Sirt1 were detected by qRT-PCR and Western blot. The results showed that C2dat1
suppression reduced cell viability, More >
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