Chijiang Gu*, Mingyuan Zhang*, Weiliang Sun*, Changzheng Dong†
Oncology Research, Vol.27, No.5, pp. 515-524, 2019, DOI:10.3727/096504018X15166183598572
Abstract Colorectal cancer (CRC) is a common clinical cancer that remains incurable in most cases. miRNAs are
reported to play a part in the development of various tumors. In the present study, we found that miR-324-5p
was downregulated in CRC cells, while ELAV (embryonic lethal, abnormal vision, Drosophila)-like protein
1 (ELAVL1) showed a higher expression. miR-324-5p transfection significantly inhibited the proliferation
as well as invasion in both SW620 and SW480 cells. miR-324-5p mimic transfection markedly decreased
the expression of ELAVL1. Luciferase reporter gene assay confirmed that ELAVL1 is a direct target of miR-
324-5p. Furthermore, cancer invasion factors uPA, uPAR, and… More >
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