Gong-Yi Lv, Jun Miao, Xiao-Lin Zhang
Oncology Research, Vol.26, No.6, pp. 837-846, 2018, DOI:10.3727/096504017X14920318811721
Abstract Abnormal expression of long noncoding RNAs (lncRNAs) often contributes to the unrestricted growth and
invasion of cancer cells. lncRNA X-inactive specific transcript (XIST) expression is upregulated in several cancers; however, its underlying mechanism in osteosarcoma (OS) has not been elucidated. In the present study,
we found that XIST expression was significantly increased in OS tissues and cell lines by LncRNA Profiler
and qRT-PCR. The effects of XIST and miR-320b on OS cell proliferation and invasion were studied by MTT
and Transwell invasion assays. The competing relationship between XIST and miR-320b was confirmed by
luciferase reporter More >
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