Xiaowen Chen*1, Jianli Chen†1
Oncology Research, Vol.26, No.3, pp. 363-372, 2018, DOI:10.3727/096504017X14953948675421
Abstract This study intended to investigate the effects of miR-3188 on breast cancer and to reveal the possible molecular
mechanisms. miR-3188 was upregulated and TUSC5 was downregulated in breast cancer tissues and MCF-7
cells compared to normal tissue and MCF-10 cells. After MCF-7 cells were transfected with miR-3188 inhibitor, cell proliferation and migration were inhibited, whereas apoptosis was promoted. Luciferase reporter assay
suggested that TUSC5 was a target gene of miR-3188. In addition, miR-3188 overexpression increased the
p-p38 expression, while miR-3188 suppression decreased the p-p38 expression significantly. miR-3188 regulated breast cancer progression via the p38 MAPK More >
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