Bao-Juan Wang^*, Hong-Wei Ding^†, Guo-An Ma^†

Oncology Research, Vol.26, No.5, pp. 675-681, 2018, DOI:10.3727/096504017X14920318811730

Abstract Melanoma is an extremely aggressive malignant skin tumor with a high mortality. Various long noncoding RNAs (lncRNAs) have been reported to be associated with the oncogenesis of melanoma. The purposes of this study were to investigate the potential role of lncRNA PVT1 in melanoma progression and to explore its possible mechanisms. A total of 35 patients who were diagnosed with malignant melanoma were enrolled in this study. Expression of PVT1 was significantly upregulated in melanoma tissue and was associated with a poor prognosis. Loss-of-function experiments showed that PVT1 knockdown markedly suppressed the proliferation activity, induced More >

Zheng-Gang Chen^*, Chuan-Yi Zheng^*, Wang-Qing Cai^†, Da-Wei Li^*, Fu-Yue Ye^*, Jian Zhou^*, Ran Wu^*, Kun Yang^*

Oncology Research, Vol.27, No.2, pp. 147-155, 2019, DOI:10.3727/096504017X15021536183517

Abstract Glioma is the most common malignant tumor of the nervous system. Studies have shown the microRNA-26b (miR-26b)/cyclooxygenase-2 (COX-2) axis in the development and progression in many tumor cells. Our study aims to investigate the effect and mechanism of the miR-26b/COX-2 axis in glioma. Decreased expression of miR-26b with increased levels of COX-2 was found in glioma tissues compared with matched normal tissues. A strong negative correlation was observed between the level of miR-26b and COX-2 in 30 glioma tissues. The miR-26b was then overexpressed by transfecting a miR-26b mimic into U-373 cells. The invasive cell More >