Juntao Wang, Guodong Sun
Oncology Research, Vol.25, No.9, pp. 1517-1527, 2017, DOI:10.3727/096504017X14859934460780
Abstract miR-26a has been found to be downregulated in osteosarcoma (OS) when compared with normal control
tissues and has been shown to suppress the malignant behaviors of OS cells. The underlying mechanism,
nevertheless, remains unknown. In our study, the long noncoding RNA MALAT1, confirmed to be significantly
upregulated in OS, is first shown to be capable of promoting proliferation and migration by directly suppressing miR-26a-5p in OS cells. In addition, we have identified forkhead box O1 (FOXO1) as a transcriptional
factor of MALAT1 that can negatively regulate MALAT1. We have shown that MALAT1 promoted growth
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