Yongcheng Mei*, Jinchun Si†, Yun Wang‡, Zhuangshi Huang§, Haiwen Zhu*, Shijun Feng*, Xuezhi Wu*, Liwen Wu*
Oncology Research, Vol.25, No.6, pp. 1027-1037, 2017, DOI:10.3727/096504016X14822800040451
Abstract Previous studies reported that elevated expression of long noncoding RNA (lncRNA) GAS5 led to the arrest
of non-small cell lung cancer (NSCLC) cell growth and a promotion of apoptosis both in vitro and in vivo.
However, its underlying molecular mechanism in NSCLC is still unclear. In the present study, we noted that
GAS5 was downregulated in NSCLC tissues and cells and was negatively correlated with miR-23a expression.
Luciferase reporter assay and qRT-PCR analysis demonstrated that GAS5 directly interacted with miR-23a
and reversely regulated its expression. miR-23a overexpression markedly promoted NSCLC cell proliferation and invasion, while More >
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