Jianping Shi*1, Yi Zhang†1, Nuyun Jin*, Yuqin Li*, Shengtian Wu*, Leiming Xu†
Oncology Research, Vol.25, No.4, pp. 523-536, 2017, DOI:10.3727/096504016X14756282819385
Abstract Gastric carcinoma is one of the most common malignancies in men, and microRNA plays a critical role in
regulating the signaling networks of gastric carcinoma tumorigenesis and metastasis. We first report the functional characteristics of miR-221-3p in gastric carcinoma. Quantification in gastric carcinoma cell lines and
tumor samples reveals significantly increasing miR-221-3p expression. Moreover, a high level of miR-221-3p
is correlated with a poor prognosis for gastric carcinoma patients. Ectopic miR-221-3p expression significantly promotes gastric carcinoma cell proliferation, invasion, and sphere formation, while silencing miR-
221-3p significantly inhibits these abilities in gastric carcinoma cells. Tests More >
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