NADIA Z. SHAABAN1, NASHWA K. IBRAHIM2, HELEN N. SAADA2, FATMA H. EL-RASHIDY1, HEBATALLAH M. SHAABAN3, NERMEEN M. ELBAKARY2,*, AHMAD S. KODOUS1,2,*
Oncology Research, Vol.30, No.6, pp. 269-276, 2022, DOI:10.32604/or.2022.027277
- 09 February 2023
Abstract Background: MicroRNAs (miRs) are small (19–25 nucleotides), non-protein coding RNAs that regulate gene
expression, and thus play essential roles in cell cycle progression. The evidence has demonstrated that the expression of
several miRs is dysregulated in human cancer. Methods: The study includes 179 female patients and 58 healthy women
Patients were identified as luminal A, B, Her-2/neu, and basal-like, as well as classified into I, II, and III stages. Analysis of
the expression fold change of miR-21 and miR-34a with molecular markers, including the oncogene Bcl-2 (B-cell
lymphoma 2) and the tumor suppressor genes BRCA1 (breast cancer More >
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