Oncology Research Editorial Office

Oncology Research, Vol.32, No.11, pp. 1811-1811, 2024, DOI:10.32604/or.2024.056887 - 16 October 2024

Abstract This article has no abstract. More >

ZULONG SHENG^*, YANRU HE, JUNYAN CAI, YUQIN JI, YUYU YAO, GENSHAN MA

BIOCELL, Vol.48, No.9, pp. 1369-1377, 2024, DOI:10.32604/biocell.2024.049905 - 04 September 2024

Abstract Background: Myocardial infarction (MI) is known worldwide for its important disabling features, including myocarditis and cardiomyocyte apoptosis. It is believed that microRNA (miRNA) has a role in the cellular processes of apoptosis and myocarditis, and miR-219a-5p has been found to suppress the inflammatory response. However, unknown is the precise mechanism by which miR-219a-5p contributes to MI. Methods: We measured the expression of miR-219a-5p and evaluated its effects on target proteins, inflammatory factors, and apoptosis in a mouse model of MI. Echocardiography was utilized to examine the MI clinical index, and triphenyl tetrazolium chloride staining was More >

WEIXUE WANG^#, TONGTONG WANG^#, YAN ZHANG, TING DENG, HAIYANG ZHANG^*, YI BA^*

Oncology Research, Vol.32, No.3, pp. 489-502, 2024, DOI:10.32604/or.2023.046676 - 06 February 2024

Abstract Different from necrosis, apoptosis, autophagy and other forms of cell death, ferroptosis is a mechanism that catalyzes lipid peroxidation of polyunsaturated fatty acids under the action of iron divalent or lipoxygenase, leading to cell death. Apatinib is currently used in the third-line standard treatment of advanced gastric cancer, targeting the anti-angiogenesis pathway. However, Apatinib-mediated ferroptosis in vascular endothelial cells has not been reported yet. Tumor-secreted exosomes can be taken up into target cells to regulate tumor development, but the mechanism related to vascular endothelial cell ferroptosis has not yet been discovered. Here, we show that More >

LAKSHANA SADU^#, R.HARI KRISHNAN^#, R.L. AKSHAYA, I. SARANYA, UDIPT RANJAN DAS, SNEHA SATISHKUMAR, N. SELVAMURUGAN^*

BIOCELL, Vol.47, No.4, pp. 751-760, 2023, DOI:10.32604/biocell.2023.026911 - 08 March 2023

Abstract MicroRNAs (miRNAs) are small non-coding RNAs (ncRNAs) that regulate the expression of their target mRNAs post-transcriptionally. Since their discovery, thousands of highly conserved miRNAs have been identified and investigated for their role in human health and diseases. MiR-214 has been increasingly reported to have an association with the regulation of bone metabolism. Reports suggested that miR-214 controls the critical aspects of osteoblasts (bone-forming cells), including their differentiation, proliferation, viability, and migration. Studies have also reported the functional significance of miR-214 in bone diseases and suggested its candidature as a diagnostic and therapeutic target. Further, targeting More >

NADIA Z. SHAABAN¹, NASHWA K. IBRAHIM², HELEN N. SAADA², FATMA H. EL-RASHIDY¹, HEBATALLAH M. SHAABAN³, NERMEEN M. ELBAKARY^2,*, AHMAD S. KODOUS^1,2,*

Oncology Research, Vol.30, No.6, pp. 269-276, 2022, DOI:10.32604/or.2022.027277 - 09 February 2023

Abstract Background: MicroRNAs (miRs) are small (19–25 nucleotides), non-protein coding RNAs that regulate gene expression, and thus play essential roles in cell cycle progression. The evidence has demonstrated that the expression of several miRs is dysregulated in human cancer. Methods: The study includes 179 female patients and 58 healthy women Patients were identified as luminal A, B, Her-2/neu, and basal-like, as well as classified into I, II, and III stages. Analysis of the expression fold change of miR-21 and miR-34a with molecular markers, including the oncogene Bcl-2 (B-cell lymphoma 2) and the tumor suppressor genes BRCA1 (breast cancer More >

Xinyue Wang^1,#, Jing Xu^1,#, Qihong Gu¹, Dingxuan Tang¹, Huoyan Ji², Shaoqing Ju², Feng Wang^2,*, Lin Chen³, Ruoyu Yuan^2,*

Oncologie, Vol.24, No.3, pp. 513-526, 2022, DOI:10.32604/oncologie.2022.024373 - 19 September 2022

Abstract Background: MicroRNAs (miRNAs) have been identified as promising novel biomarkers for cancer diagnosis and prognosis, especially for hepatocellular carcinoma (HCC). Nowadays, the expression level of miR-21 in serum samples is a diagnostic indicator for HCC diagnosis. Thus, the quantitative determination of miRNA concentration is of significance in clinical practice. It is particularly important to establish an analytical detection method for miR-21 in patient serum. Methods: The signal readout for miR-21 was based on the mass response of a reporter peptide using an isotope dilution mass spectrometry (MS) method in this work. To be more specific, miR-21… More >

Li Xu, Kang Li, Jia Li, Liyu Liu, Fang Xu, Yan Xu, Yi Kong, Xingxiang Pu, Qianzhi Wang, Jingyi Wang, Bolin Chen^*, Lin Wu^*

Oncologie, Vol.24, No.3, pp. 579-590, 2022, DOI:10.32604/oncologie.2022.022121 - 19 September 2022

Abstract Background: Non-small cell lung cancer (NSCLC), caused by abnormal gene drive, may have primary drug resistance after treatment with tyrosine kinase inhibitors (EGFR-TKIs). Therefore, we explore whether the primary drug-resistant NSCLC treated with EGFR-TKI is related to the miR-21/Sonic Hedgehog (SHH)/PI3K/AKT pathway. Methods: The patients from our hospital who meet the AJCC TNM staging (7th edition) stage IIIB and stage IV NSCLC were selected in this case study. Thereafter, the treatment response of EGFR-TKIs was evaluated according to the solid tumor efficacy evaluation standard (version 1.1). The patients were divided into the EGFR-TKIs primary drug resistance group… More >

CHANG CHEN^1,#, LIMIN QIAO^2,#, KAIJUN GUO¹, YINGQIU WANG¹, MENGYI YUAN³, BOFAN FU⁴, XIAOBO GAO³, HEMIN NI¹, LONGFEI XIAO^1,*, XIANGGUO WANG^1,*

BIOCELL, Vol.46, No.11, pp. 2415-2423, 2022, DOI:10.32604/biocell.2022.021510 - 07 July 2022

Abstract Endometritis affects the reproductive capacity of dairy cows and leads to serious economic losses in dairy farming. Clarification of the pathogenesis of endometritis is necessary to improve the reproductive efficiency of dairy cows. Exosomes and their miRNAs have been proven to play an important role in inflammatory regulation. Exosomal miR-218 is a differentially expressed miRNA found in endometrial epithelial cells (EECs) under endometrial inflammation. Therefore, we investigated the expression of miR-218 in the uterine tissue of dairy cows, lipopolysaccharide (LPS) treated EECs, exosomal vesicles, and regulation of exosomal miR-218 by targeting TGIF-2 inducible factor homology… More >

LI JIANG^1,*, KE ZHANG¹, CHONG HU¹, HONGWEI ZHANG¹, DANPU WANG¹, WEIWEI ZHAI²

BIOCELL, Vol.46, No.4, pp. 969-978, 2022, DOI:10.32604/biocell.2022.017765 - 15 December 2021

Abstract In recent decades, RNA binding motif (RBM) proteins have been widespread concerned by researchers. Among them, RBM5 is considered as a potential tumor suppressor gene in HCC. RBM10, also belonging to the RBM family, have similar structure and high homology with RBM5, indicating its potential as potential tumor suppressor genes. However, the role of RBM10 in tumors is controversial. The purpose of this study was to analyze the expression correlation and functional relationship of miR-21 and RBM10 in human hepatocellular carcinoma (HCC) tissues and corresponding tumor cells. Bioinformatics analysis showed that miR-21 and RBM10 were… More >

FEI TIAN^*, GANG LIU, LINLIN FAN, ZHONGYUN CHEN, YAN LIANG,

BIOCELL, Vol.45, No.1, pp. 49-56, 2021, DOI:10.32604/biocell.2021.013794 - 26 January 2021

Abstract Cerebral ischemia is due to the formation of blood clots or embolisms in the brain arteries, which leads to local brain tissue necrosis and neural cell apoptosis. Recent studies have shown that microRNA (miRNA) plays an important regulatory role in the pathological process of ischemic injury. The aim of this study is to investigate the role and the mechanism of miR-21-3p and drosophila mothers against decapentaplegic 2 (SMAD2) in cerebral ischemic reperfusion injured (CIRI) neural cells. The CIRI model was established by oxygen-glucose deprivation and recovery process for N2a cells. The cell viability and the… More >