Xinyang Lu, Zhiqiang Liu, Xiaofei Ning, Lunhua Huang, Biao Jiang
Oncology Research, Vol.26, No.3, pp. 473-481, 2018, DOI:10.3727/096504017X15105708598531
Abstract The long noncoding RNA HOX transcript antisense RNA (HOTAIR) has been found to be overexpressed in
many human malignancies and involved in tumor progression and metastasis. Although the downstream target
through which HOTAIR modulates tumor metastasis is not well known, evidence suggests that microRNA-197
(miR-197) might be involved in this event. In the present study, the significance of HOTAIR and miR-197 in
the progression of colorectal cancer was detected in vitro and in vivo. We found that HOTAIR expression was
significantly increased in colorectal cancer cells and tissues. In contrast, the expression of miR-197 was More >
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