Yuping Peng, Xuning Shen, Honggang Jiang, Zhiheng Chen, Jiaming Wu, Yi Zhu, Yuan Zhou, Jin Li
Oncology Research, Vol.27, No.1, pp. 65-71, 2019, DOI:10.3727/096504018X15191223015016
Abstract MicroRNAs (miRNAs) have been demonstrated to be essential regulators in the development and progression
of various cancers. The role of miR-188-5p in gastric cancer (GC) has not been determined. In this study, we
found that the expression of miR-188-5p was downregulated in GC tissues compared with adjacent normal tissues. The lowly expressed miR-188-5p was significantly associated with lymph node metastasis and advanced
TNM stage. Moreover, overexpression of miR-188-5p significantly inhibited GC cell proliferation, migration,
and invasion but promoted cellular apoptosis. Mechanistically, we identified transcription factor ZFP91 as a
target gene of miR-188-5p in GC. We found that miR-188-5p overexpression significantly… More >
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