Dayong Yan*1, Xiaoqing Cai*1, Yu Feng†
Oncology Research, Vol.24, No.6, pp. 399-404, 2016, DOI:10.3727/096504016X14685034103239
Abstract This study was designed to investigate the role of miR-183 in modulating cell growth and apoptosis of tongue
squamous cell carcinoma SCC25 cell line. Human squamous epithelial cell and squamous cell carcinoma cell
line SCC25 was used, and miR-183 was inhibited. Cell growth, colony formation, and apoptotic rate, as well
as the expression of caspase 3 and BCL-xL, were detected. Results showed that miR-183 was significantly
overexpressed in the SCC25 cell line when compared with normal control. The miR-183 inhibitor reduced cell
growth and colony formation, while the apoptosis percentage was significantly increased. The expression More >
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